SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4clc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		6 / 10 LEU E 151
ALA E 160
ILE E  63
GLY E  43
VAL E  59
ILE E 148
 None
 1.23A 1hsgA-4clcE:
undetectable		 1hsgA-4clcE:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 9 LEU E 151
ILE E  63
GLY E  43
VAL E  59
ILE E 148
 None
 1.09A 2avoA-4clcE:
undetectable		 2avoA-4clcE:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 12 LEU E 146
ASP E 156
LEU E 151
VAL E  59
ALA E  60
 None
 1.23A 2kceB-4clcE:
undetectable		 2kceB-4clcE:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 12 ILE E  46
GLY E  43
ASN E  84
LEU E 151
THR E 147
 None
 1.14A 3eeyC-4clcE:
undetectable		 3eeyC-4clcE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 10 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
 None
 0.99A 3em3B-4clcE:
undetectable		 3em3B-4clcE:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 12 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
 None
 0.95A 3lzsA-4clcE:
undetectable		 3lzsA-4clcE:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 10 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
 None
 1.04A 3oxwD-4clcE:
undetectable		 3oxwD-4clcE:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
 None
 0.93A 3oy4A-4clcE:
undetectable		 3oy4A-4clcE:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		4 / 5 LEU E  19
HIS E 100
HIS E 157
GLU E  26
 None
 1.28A 4a7bB-4clcE:
undetectable		 4a7bB-4clcE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
 None
 0.98A 4dqhA-4clcE:
undetectable		 4dqhA-4clcE:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
 None
 0.96A 4hlaB-4clcE:
undetectable		 4hlaB-4clcE:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		6 / 11 LEU E 151
ALA E 160
ILE E  63
GLY E  43
VAL E  59
ILE E 148
 None
 1.35A 4qgiB-4clcE:
undetectable		 4qgiB-4clcE:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		4 / 7 LEU E 164
SER E 163
ILE E  46
VAL E  50
 None
 1.21A 4tvtA-4clcE:
undetectable		 4tvtA-4clcE:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		4 / 7 ARG E  90
SER E 122
GLY E 129
GLU E 154
 None
 1.13A 5btfA-4clcE:
1.8
5btfC-4clcE:
undetectable
5btfD-4clcE:
undetectable		 5btfA-4clcE:
16.20
5btfC-4clcE:
16.20
5btfD-4clcE:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 12 LEU E 151
ALA E 160
GLY E  43
VAL E  59
ILE E 148
 None
 1.07A 5kqyA-4clcE:
undetectable		 5kqyA-4clcE:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		4 / 4 LEU E  42
LEU E  31
SER E 163
ALA E 168
 None
 1.12A 5uunA-4clcE:
undetectable		 5uunA-4clcE:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 4clc UPF0303 PROTEIN
YBR137W
(Saccharomyces
cerevisiae) 		5 / 9 THR E 147
GLY E 130
GLY E 129
HIS E 128
CYH E 107
 None
 1.25A 6gnfA-4clcE:
undetectable		 6gnfA-4clcE:
15.86