SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 7 ASP A 499
ASP A 422
TYR A 479
TYR A 477
 None
PO4  A1560 ( 4.9A)
None
PO4  A1560 (-4.3A)
 1.17A 1ceaB-4cmnA:
undetectable		 1ceaB-4cmnA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 7 ARG A 504
VAL A 417
ASN A 467
ASP A 465
 None
 1.30A 1hwiC-4cmnA:
undetectable		 1hwiC-4cmnA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 7 ARG A 504
VAL A 417
ASN A 467
ASP A 465
 None
 1.30A 1hwiD-4cmnA:
undetectable		 1hwiD-4cmnA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 12 LEU A 325
GLU A 294
LEU A 316
THR A 343
VAL A 358
 None
 1.20A 1n5xA-4cmnA:
undetectable		 1n5xA-4cmnA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 12 LEU A 325
GLU A 294
LEU A 316
THR A 343
VAL A 358
 None
 1.20A 1n5xB-4cmnA:
undetectable		 1n5xB-4cmnA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 8 ARG A 426
HIS A 524
ASP A 499
ALA A 378
 None
PO4  A1560 (-3.8A)
None
GOL  A1562 ( 4.4A)
 0.93A 2rk8A-4cmnA:
undetectable		 2rk8A-4cmnA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 6 GLY A 347
GLY A 345
GLY A 356
GLY A 353
GLY A 357
 None
 1.23A 3bogA-4cmnA:
undetectable
3bogC-4cmnA:
undetectable		 3bogA-4cmnA:
undetectable
3bogC-4cmnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 12 LEU A 453
GLY A 421
ILE A 501
GLY A 245
ASP A 422
 None
None
None
None
PO4  A1560 ( 4.9A)
 1.02A 3bwcB-4cmnA:
undetectable		 3bwcB-4cmnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 12 PHE A 286
LEU A 279
GLY A 251
ASN A 354
ILE A 348
 None
None
None
GOL  A1562 (-4.1A)
None
 1.13A 3eeoA-4cmnA:
2.8		 3eeoA-4cmnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 12 LEU A 519
ALA A 300
GLY A 304
GLY A 257
TRP A 297
 None
 1.20A 3ou7A-4cmnA:
undetectable		 3ou7A-4cmnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 9 PHE A 466
ASP A 422
LEU A 423
GLY A 421
ASN A 373
 None
PO4  A1560 ( 4.9A)
None
None
None
 1.43A 4eb4C-4cmnA:
undetectable		 4eb4C-4cmnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		3 / 3 LEU A 519
LYS A 520
THR A 521
 None
 0.52A 4lj0A-4cmnA:
undetectable		 4lj0A-4cmnA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 4 LEU A 325
ILE A 326
GLY A 275
ILE A 371
 None
 0.88A 5dzk3-4cmnA:
undetectable
5dzkm-4cmnA:
undetectable		 5dzk3-4cmnA:
0.85
5dzkm-4cmnA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		3 / 3 ARG A 426
HIS A 379
ARG A 493
 None
GOL  A1562 (-4.2A)
None
 1.15A 5iaoC-4cmnA:
undetectable		 5iaoC-4cmnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		3 / 3 ARG A 426
HIS A 379
ARG A 493
 None
GOL  A1562 (-4.2A)
None
 1.13A 5iaoF-4cmnA:
undetectable		 5iaoF-4cmnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 9 GLY A 321
VAL A 317
GLY A 353
PHE A 399
ILE A 411
 None
 0.94A 5vkqC-4cmnA:
undetectable
5vkqD-4cmnA:
undetectable		 5vkqC-4cmnA:
11.72
5vkqD-4cmnA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 6 LEU A 376
TYR A 513
ASP A 451
GLN A 445
 None
 1.50A 6djzC-4cmnA:
undetectable		 6djzC-4cmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 12 GLY A 428
GLU A 434
VAL A 435
LEU A 438
ILE A 439
 None
 0.98A 6ectA-4cmnA:
undetectable		 6ectA-4cmnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 4 LEU A 530
ASP A 270
PRO A 269
ARG A 241
 None
 1.39A 6fgdA-4cmnA:
undetectable		 6fgdA-4cmnA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 8 ASP A 499
GLY A 353
ASN A 373
VAL A 358
 None
 1.08A 6giqL-4cmnA:
undetectable
6giqP-4cmnA:
undetectable
6giqT-4cmnA:
undetectable		 6giqL-4cmnA:
21.75
6giqP-4cmnA:
20.83
6giqT-4cmnA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 12 PHE A 286
GLY A 321
LEU A 279
GLY A 251
ILE A 348
 None
 0.91A 6mhtA-4cmnA:
2.4		 6mhtA-4cmnA:
22.45