SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 5 THR A  83
THR A 109
HIS A   8
LEU A 254
 None
 1.03A 1d4fC-4cmrA:
undetectable		 1d4fC-4cmrA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 8 ASP A 253
PHE A 218
SER A 318
ALA A 217
 None
 0.85A 1rqpC-4cmrA:
undetectable		 1rqpC-4cmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 8 ASP A 253
PHE A 218
SER A 318
ALA A 217
 None
 0.80A 1rqpA-4cmrA:
undetectable		 1rqpA-4cmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 LEU A 396
PHE A 395
ARG A 405
 None
 0.83A 1xdkF-4cmrA:
undetectable		 1xdkF-4cmrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 10 PHE A 362
GLY A 463
ILE A 468
LEU A 497
PHE A 366
 None
 1.14A 1z11C-4cmrA:
undetectable		 1z11C-4cmrA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 10 ASN A 488
GLU A 368
LEU A 365
LEU A 503
TYR A 507
 None
 0.94A 2ha6A-4cmrA:
undetectable		 2ha6A-4cmrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 10 ASN A 488
GLU A 368
LEU A 365
LEU A 503
TYR A 507
 None
 0.92A 2ha6B-4cmrA:
undetectable		 2ha6B-4cmrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 PHE A 134
PHE A 149
PHE A 174
 None
 0.81A 2od9A-4cmrA:
undetectable		 2od9A-4cmrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 PHE A 134
PHE A 149
PHE A 174
 None
 0.81A 2qqgA-4cmrA:
undetectable		 2qqgA-4cmrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 8 ASP A 253
PHE A 218
SER A 318
ALA A 217
 None
 0.81A 2v7uA-4cmrA:
undetectable		 2v7uA-4cmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 6 THR A 111
VAL A 112
LEU A 151
SER A 130
 None
 1.25A 3b6rB-4cmrA:
undetectable		 3b6rB-4cmrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 LEU A 176
LEU A 175
ALA A 161
THR A 165
VAL A 172
 None
 1.17A 3cwkA-4cmrA:
undetectable		 3cwkA-4cmrA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 7 GLY A 463
PHE A 360
PHE A 362
PHE A 500
 None
 1.10A 3ko0L-4cmrA:
undetectable
3ko0N-4cmrA:
undetectable		 3ko0L-4cmrA:
11.89
3ko0N-4cmrA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 ARG A  68
PHE A 411
HIS A 407
ILE A  98
ASP A  64
 None
 1.31A 3lcvB-4cmrA:
undetectable		 3lcvB-4cmrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 7 TYR A  95
LEU A 254
LEU A  84
PHE A 140
 None
 1.10A 3nk2X-4cmrA:
undetectable		 3nk2X-4cmrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 TYR A 538
ASP A 562
ASP A 566
 None
 0.81A 3r24A-4cmrA:
undetectable		 3r24A-4cmrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 ARG A 398
PRO A 429
PHE A 395
 None
 1.01A 3thrC-4cmrA:
undetectable		 3thrC-4cmrA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 10 HIS A   8
ASP A  78
HIS A  10
PRO A 116
HIS A 115
 None
 0.99A 4bz6A-4cmrA:
undetectable		 4bz6A-4cmrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 HIS A   8
ASP A  78
HIS A  10
PRO A 116
HIS A 115
 None
 0.98A 4bz6A-4cmrA:
undetectable
4bz6B-4cmrA:
undetectable		 4bz6A-4cmrA:
22.26
4bz6B-4cmrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 HIS A   8
ASP A  78
HIS A  10
PRO A 116
HIS A 115
 None
 0.95A 4bz6C-4cmrA:
undetectable		 4bz6C-4cmrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 10 HIS A   8
ASP A  78
HIS A  10
PRO A 116
HIS A 115
 None
 1.00A 4bz6D-4cmrA:
undetectable		 4bz6D-4cmrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 6 LEU A  67
LEU A  70
ILE A 281
TRP A 270
 None
 0.96A 4do3B-4cmrA:
undetectable		 4do3B-4cmrA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 7 PHE A 362
ILE A 117
PRO A 450
HIS A 447
 None
 1.13A 4g5jA-4cmrA:
undetectable		 4g5jA-4cmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 TYR A   7
ARG A 208
SER A 251
 None
 1.12A 4khpI-4cmrA:
undetectable
4khpJ-4cmrA:
undetectable		 4khpI-4cmrA:
12.06
4khpJ-4cmrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 8 ARG A 451
ASP A 319
GLU A 153
ARG A 339
 None
 1.35A 4kr4C-4cmrA:
undetectable		 4kr4C-4cmrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.44A 4njgA-4cmrA:
1.6		 4njgA-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.44A 4njgB-4cmrA:
undetectable		 4njgB-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.44A 4njhA-4cmrA:
undetectable		 4njhA-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.44A 4njhB-4cmrA:
2.9		 4njhB-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.41A 4njiA-4cmrA:
2.9		 4njiA-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.43A 4njiB-4cmrA:
1.6		 4njiB-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.41A 4njjA-4cmrA:
2.8		 4njjA-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.42A 4njjB-4cmrA:
0.0		 4njjB-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.40A 4njkA-4cmrA:
undetectable		 4njkA-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 GLU A 580
ASP A  16
THR A 574
ASN A 587
VAL A  38
 None
 1.41A 4njkB-4cmrA:
undetectable		 4njkB-4cmrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 MET A 476
MET A 442
TYR A 494
 None
 1.07A 4p6xI-4cmrA:
undetectable		 4p6xI-4cmrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 7 ASP A 331
PRO A 116
THR A 157
ASP A 159
 None
 1.09A 4pcuA-4cmrA:
undetectable		 4pcuA-4cmrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 7 ASP A 331
PRO A 152
THR A 157
ASP A 159
 None
 1.09A 4pcuA-4cmrA:
undetectable		 4pcuA-4cmrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		3 / 3 LEU A 503
ASP A 506
TYR A 507
 None
 0.57A 4qc6B-4cmrA:
undetectable		 4qc6B-4cmrA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 HIS A 346
GLU A 519
GLY A 514
GLY A 336
LEU A 323
 None
 1.09A 4uilH-4cmrA:
undetectable
4uilL-4cmrA:
undetectable		 4uilH-4cmrA:
16.46
4uilL-4cmrA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 HIS A 346
GLU A 519
GLY A 514
GLY A 336
LEU A 323
 None
 1.28A 4uinH-4cmrA:
undetectable
4uinL-4cmrA:
undetectable		 4uinH-4cmrA:
16.52
4uinL-4cmrA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 ILE A 271
ILE A 281
VAL A  75
VAL A  77
PHE A   9
 None
 1.08A 4y0pA-4cmrA:
undetectable		 4y0pA-4cmrA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 11 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.14A 4ygfA-4cmrA:
undetectable		 4ygfA-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 11 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.11A 4ygfC-4cmrA:
undetectable		 4ygfC-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 11 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.12A 4ygfD-4cmrA:
undetectable		 4ygfD-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.12A 4ygfG-4cmrA:
undetectable		 4ygfG-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.25A 4yhaA-4cmrA:
undetectable		 4yhaA-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 10 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.19A 4yhaB-4cmrA:
undetectable		 4yhaB-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.14A 4yhaE-4cmrA:
undetectable		 4yhaE-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		5 / 12 ASN A 539
VAL A 541
VAL A 465
LEU A 365
ALA A 361
 None
 1.09A 4yhaG-4cmrA:
undetectable		 4yhaG-4cmrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 7 ILE A 378
PHE A 375
LYS A 393
SER A 122
 None
 1.47A 5nr3A-4cmrA:
undetectable		 5nr3A-4cmrA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN
(Pyrococcus
sp.
ST04) 		4 / 6 GLU A  80
TRP A 150
HIS A  10
ALA A  11
 None
 1.45A 6f6jC-4cmrA:
undetectable
6f6jD-4cmrA:
undetectable		 6f6jC-4cmrA:
20.57
6f6jD-4cmrA:
20.57