SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 100
SER A  59
ILE A  60
TYR A  51
TYR A 233
 None
 1.46A 1ot7B-4cmwA:
undetectable		 1ot7B-4cmwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 162
ASP A 214
ASN A 163
ASP A  34
 None
None
None
PEG  A1299 ( 3.6A)
 0.94A 2g72B-4cmwA:
undetectable		 2g72B-4cmwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 119
LEU A 144
ILE A 146
GLU A 196
 EDO  A1297 (-3.9A)
None
None
None
 1.07A 2qqdA-4cmwA:
undetectable
2qqdE-4cmwA:
undetectable		 2qqdA-4cmwA:
13.46
2qqdE-4cmwA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 216
GLY A 162
TYR A 121
 None
 0.70A 2vouA-4cmwA:
undetectable		 2vouA-4cmwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 216
GLY A 162
TYR A 121
 None
 0.69A 2vouB-4cmwA:
undetectable		 2vouB-4cmwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 216
GLY A 162
TYR A 121
 None
 0.69A 2vouC-4cmwA:
undetectable		 2vouC-4cmwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  60
PHE A 120
VAL A 118
VAL A 116
PHE A 158
 None
 1.08A 2ygpA-4cmwA:
undetectable		 2ygpA-4cmwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 158
TYR A 194
GLY A 122
ILE A  78
PHE A 213
 None
 1.29A 2zznB-4cmwA:
undetectable		 2zznB-4cmwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  70
VAL A  21
LEU A 244
PRO A  26
 None
 0.70A 3bgdB-4cmwA:
2.3		 3bgdB-4cmwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 122
TYR A 121
GLY A 159
ASP A 214
 None
 1.03A 3kl3A-4cmwA:
undetectable		 3kl3A-4cmwA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 196
GLU A 191
TYR A 194
ARG A 155
 None
 1.02A 4fgzA-4cmwA:
undetectable		 4fgzA-4cmwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 244
ILE A  71
HIS A  69
VAL A  21
 None
 1.31A 4xyzA-4cmwA:
undetectable		 4xyzA-4cmwA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 196
TYR A 197
ARG A 187
 None
 0.71A 5uunA-4cmwA:
undetectable		 5uunA-4cmwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 196
TYR A 197
ARG A 187
 None
 0.71A 5uunB-4cmwA:
undetectable		 5uunB-4cmwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4cmw DITERPENE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 120
VAL A 198
PRO A  77
VAL A 160
 None
 1.32A 6ekzA-4cmwA:
undetectable		 6ekzA-4cmwA:
13.75