SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 12 SER A  78
GLY A 111
ILE A 131
VAL A 139
LEU A 140
SAH  A1158 ( 2.6A)
SAH  A1157 (-3.1A)
SAH  A1157 (-3.6A)
SAH  A1157 ( 4.3A)
SAH  A1157 (-3.8A)
0.84A 1uakA-4cngA:
7.3
1uakA-4cngA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
6 / 12 PHE A 110
GLY A 111
GLY A 116
ILE A 131
LEU A 140
ALA A 145
SAH  A1157 (-4.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 3.7A)
0.40A 1v2xA-4cngA:
16.9
1v2xA-4cngA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
6 / 12 PHE A 110
GLY A 111
GLY A 116
ILE A 131
SER A  79
ALA A 145
SAH  A1157 (-4.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-4.5A)
SAH  A1157 ( 3.7A)
1.26A 1v2xA-4cngA:
16.9
1v2xA-4cngA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
6 / 11 THR A  77
GLY A 111
GLY A 116
ILE A 131
LEU A 140
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 3.7A)
0.51A 1x7pA-4cngA:
10.3
1x7pB-4cngA:
17.8
1x7pA-4cngA:
21.38
1x7pB-4cngA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
6 / 10 THR A  77
GLY A 111
GLY A 116
ILE A 131
LEU A 140
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 3.7A)
0.49A 1x7pA-4cngA:
18.0
1x7pB-4cngA:
17.8
1x7pA-4cngA:
21.38
1x7pB-4cngA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
4 / 8 ILE A 109
ARG A 112
LEU A 117
GLU A 121
None
None
SAH  A1158 (-4.8A)
None
0.70A 2cdqA-4cngA:
undetectable
2cdqA-4cngA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
6 / 11 THR A  77
GLY A 111
GLY A 116
ILE A 131
LEU A 140
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 3.7A)
0.54A 3dcmX-4cngA:
15.6
3dcmX-4cngA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
6 / 11 THR A  77
GLY A 111
GLY A 116
ILE A 131
SER A 143
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
None
SAH  A1157 ( 3.7A)
1.24A 3dcmX-4cngA:
15.6
3dcmX-4cngA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 12 ASN A  15
GLY A 111
GLY A 116
ILE A 131
ASN A 141
None
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
None
0.59A 3nk7A-4cngA:
17.0
3nk7A-4cngA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
6 / 12 ASN A  15
PHE A 110
GLY A 111
GLY A 116
ILE A 131
LEU A 140
None
SAH  A1157 (-4.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
0.65A 3nk7B-4cngA:
17.0
3nk7B-4cngA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 12 GLY A 111
GLU A 113
GLY A 116
ILE A 131
LEU A 140
SAH  A1157 (-3.1A)
None
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
0.97A 3nk7B-4cngA:
17.0
3nk7B-4cngA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
4 / 7 ASN A  15
ILE A  19
PHE A  31
MET A  58
None
1.26A 3tvxB-4cngA:
undetectable
3tvxB-4cngA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
3 / 3 GLU A  42
ALA A  43
PHE A  46
None
0.59A 4v1fA-4cngA:
undetectable
4v1fA-4cngA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
3 / 3 GLU A  42
ALA A  43
PHE A  46
None
0.63A 4v1fC-4cngA:
undetectable
4v1fC-4cngA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
7 / 12 THR A  77
GLY A 111
GLY A 116
ILE A 131
LEU A 140
LEU A 142
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 4.4A)
SAH  A1157 ( 3.7A)
0.29A 5l0zA-4cngA:
19.1
5l0zA-4cngA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
7 / 10 THR A  77
GLY A 111
GLY A 116
ILE A 131
LEU A 140
LEU A 142
ALA A 145
SAH  A1157 (-3.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 4.4A)
SAH  A1157 ( 3.7A)
0.30A 5l0zB-4cngA:
7.3
5l0zB-4cngA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 10 GLY A 111
GLY A 116
VAL A 139
LEU A 140
ALA A 145
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 ( 4.3A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 3.7A)
0.60A 5o96C-4cngA:
13.4
5o96D-4cngA:
13.8
5o96C-4cngA:
24.10
5o96D-4cngA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 10 GLY A 111
GLY A 116
VAL A 139
LEU A 140
ALA A 145
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 ( 4.3A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 3.7A)
0.62A 5o96E-4cngA:
13.6
5o96F-4cngA:
10.9
5o96E-4cngA:
24.10
5o96F-4cngA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 11 GLY A 111
GLU A 113
GLY A 116
VAL A 139
ALA A 145
SAH  A1157 (-3.1A)
None
SAH  A1157 ( 3.2A)
SAH  A1157 ( 4.3A)
SAH  A1157 ( 3.7A)
0.93A 5o96G-4cngA:
13.0
5o96G-4cngA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 10 GLY A 111
GLY A 116
VAL A 139
LEU A 140
ALA A 145
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 ( 4.3A)
SAH  A1157 (-3.8A)
SAH  A1157 ( 3.7A)
0.55A 5o96G-4cngA:
13.1
5o96H-4cngA:
14.2
5o96G-4cngA:
24.10
5o96H-4cngA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)
4cng SPOU RRNA METHYLASE
(Sulfolobus
acidocaldarius)
5 / 12 GLU A  52
GLY A  50
ALA A  48
ALA A  20
PHE A  31
None
1.06A 5zw4A-4cngA:
undetectable
5zw4A-4cngA:
22.10