SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		3 / 3 THR C 137
PRO C 139
THR C 138
 None
 0.86A 1a7yB-4cniC:
undetectable		 1a7yB-4cniC:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		5 / 10 GLY C  90
LEU C 126
PHE C 170
THR C 119
LEU C 122
 None
 1.42A 1a8uA-4cniC:
undetectable		 1a8uA-4cniC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		5 / 10 GLY C  90
LEU C 126
PHE C 170
THR C 119
LEU C 122
 None
 1.46A 1a8uB-4cniC:
undetectable		 1a8uB-4cniC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		3 / 3 THR C 137
PRO C 139
THR C 138
 None
 0.95A 1dscC-4cniC:
undetectable		 1dscC-4cniC:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		4 / 8 PHE C 105
SER C 107
ALA C  38
LEU C  39
 None
 1.02A 2o01A-4cniC:
undetectable		 2o01A-4cniC:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		4 / 5 LEU C  91
GLY C  90
PHE C  94
PHE C 170
 None
 1.20A 3smtA-4cniC:
undetectable		 3smtA-4cniC:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		4 / 8 LEU C  62
VAL C  96
TYR C 100
LEU C 165
 None
 1.11A 3v81A-4cniC:
undetectable		 3v81A-4cniC:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4cni INTERLEUKIN-6
(Homo
sapiens) 		5 / 12 ASP C  71
LEU C  33
LEU C 178
GLY C  90
LEU C  91
 None
 0.93A 6b0iB-4cniC:
undetectable		 6b0iB-4cniC:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 4cni OLOKIZUMAB HEAVY
CHAIN, FAB PORTION
(Homo
sapiens) 		3 / 3 PRO A 192
SER A 194
SER A 195
 None
 0.59A 6bpyA-4cniA:
undetectable		 6bpyA-4cniA:
20.75