SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cnk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 8 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.78A 1c9sI-4cnkA:
undetectable
1c9sJ-4cnkA:
undetectable		 1c9sI-4cnkA:
12.76
1c9sJ-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.36A 1c9sJ-4cnkA:
undetectable
1c9sK-4cnkA:
undetectable		 1c9sJ-4cnkA:
12.76
1c9sK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.78A 1c9sN-4cnkA:
undetectable
1c9sO-4cnkA:
undetectable		 1c9sN-4cnkA:
12.76
1c9sO-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.79A 1c9sP-4cnkA:
undetectable
1c9sQ-4cnkA:
undetectable		 1c9sP-4cnkA:
12.76
1c9sQ-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.78A 1c9sQ-4cnkA:
undetectable
1c9sR-4cnkA:
undetectable		 1c9sQ-4cnkA:
12.76
1c9sR-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 8 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.79A 1c9sU-4cnkA:
undetectable
1c9sV-4cnkA:
undetectable		 1c9sU-4cnkA:
12.76
1c9sV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.81A 1c9sL-4cnkA:
undetectable
1c9sV-4cnkA:
undetectable		 1c9sL-4cnkA:
12.76
1c9sV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.97A 1dhiA-4cnkA:
undetectable		 1dhiA-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.96A 1dhiB-4cnkA:
undetectable		 1dhiB-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.98A 1dhjA-4cnkA:
undetectable		 1dhjA-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.96A 1dhjB-4cnkA:
undetectable		 1dhjB-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.00A 1draA-4cnkA:
undetectable		 1draA-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.99A 1draB-4cnkA:
undetectable		 1draB-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.98A 1drbA-4cnkA:
undetectable		 1drbA-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.97A 1drbB-4cnkA:
undetectable		 1drbB-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 1gtfA-4cnkA:
undetectable
1gtfB-4cnkA:
undetectable		 1gtfA-4cnkA:
12.76
1gtfB-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.83A 1gtfD-4cnkA:
undetectable
1gtfE-4cnkA:
undetectable		 1gtfD-4cnkA:
12.76
1gtfE-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 1gtfH-4cnkA:
undetectable
1gtfI-4cnkA:
undetectable		 1gtfH-4cnkA:
12.76
1gtfI-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.82A 1gtfJ-4cnkA:
undetectable
1gtfK-4cnkA:
undetectable		 1gtfJ-4cnkA:
12.76
1gtfK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.80A 1gtfQ-4cnkA:
undetectable
1gtfR-4cnkA:
undetectable		 1gtfQ-4cnkA:
12.76
1gtfR-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.79A 1gtfR-4cnkA:
undetectable
1gtfS-4cnkA:
undetectable		 1gtfR-4cnkA:
12.76
1gtfS-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.81A 1gtfS-4cnkA:
undetectable
1gtfT-4cnkA:
undetectable		 1gtfS-4cnkA:
12.76
1gtfT-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 7 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.75A 1gtnA-4cnkA:
undetectable
1gtnK-4cnkA:
undetectable		 1gtnA-4cnkA:
12.76
1gtnK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 8 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.74A 1gtnE-4cnkA:
undetectable
1gtnF-4cnkA:
undetectable		 1gtnE-4cnkA:
12.76
1gtnF-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.77A 1gtnT-4cnkA:
undetectable
1gtnU-4cnkA:
undetectable		 1gtnT-4cnkA:
12.76
1gtnU-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.83A 1gtnL-4cnkA:
undetectable
1gtnV-4cnkA:
undetectable		 1gtnL-4cnkA:
12.76
1gtnV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 8 GLY A 126
ILE A   8
LEU A  31
ASP A   5
 None
 0.87A 1jg4A-4cnkA:
2.3		 1jg4A-4cnkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ASP A 178
ARG A 181
GLY A 337
THR A 335
GLY A 163
 None
None
None
None
FAD  A1392 (-3.3A)
 1.46A 1jr1A-4cnkA:
undetectable		 1jr1A-4cnkA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.00A 1ra2A-4cnkA:
undetectable		 1ra2A-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.06A 1ra3A-4cnkA:
undetectable		 1ra3A-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.93A 1rb2A-4cnkA:
undetectable		 1rb2A-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.04A 1rb2B-4cnkA:
undetectable		 1rb2B-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.00A 1rb3B-4cnkA:
undetectable		 1rb3B-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.98A 1rx2A-4cnkA:
undetectable		 1rx2A-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.80A 1utdE-4cnkA:
undetectable
1utdF-4cnkA:
undetectable		 1utdE-4cnkA:
12.76
1utdF-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.80A 1utdH-4cnkA:
undetectable
1utdI-4cnkA:
undetectable		 1utdH-4cnkA:
12.76
1utdI-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 8 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.72A 1utdI-4cnkA:
undetectable
1utdJ-4cnkA:
undetectable		 1utdI-4cnkA:
12.76
1utdJ-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.80A 1utdL-4cnkA:
undetectable
1utdM-4cnkA:
undetectable		 1utdL-4cnkA:
12.76
1utdM-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.79A 1utdO-4cnkA:
undetectable
1utdP-4cnkA:
undetectable		 1utdO-4cnkA:
12.76
1utdP-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.77A 1utdP-4cnkA:
undetectable
1utdQ-4cnkA:
undetectable		 1utdP-4cnkA:
12.76
1utdQ-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.80A 1utdS-4cnkA:
undetectable
1utdT-4cnkA:
undetectable		 1utdS-4cnkA:
12.76
1utdT-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
GLY A  26
 None
 0.78A 1utdU-4cnkA:
undetectable
1utdV-4cnkA:
undetectable		 1utdU-4cnkA:
12.76
1utdV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.79A 1utdL-4cnkA:
undetectable
1utdV-4cnkA:
undetectable		 1utdL-4cnkA:
12.76
1utdV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLU A  33
GLY A  15
GLY A  12
ILE A 129
LEU A  32
 FAD  A1392 (-2.7A)
None
FAD  A1392 (-3.4A)
None
None
 1.02A 1x7pA-4cnkA:
3.0
1x7pB-4cnkA:
3.0		 1x7pA-4cnkA:
22.25
1x7pB-4cnkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.93A 2d0kA-4cnkA:
undetectable		 2d0kA-4cnkA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.03A 2drcB-4cnkA:
undetectable		 2drcB-4cnkA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ALA A 378
GLY A  10
LYS A  34
GLU A 133
ILE A 134
 FAD  A1392 ( 3.7A)
FAD  A1392 (-3.0A)
FAD  A1392 (-3.8A)
None
FAD  A1392 (-4.2A)
 0.72A 2plwA-4cnkA:
undetectable		 2plwA-4cnkA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ASP A 213
ASP A  99
ARG A 102
ALA A 239
HIS A 225
 None
None
SO4  A1396 (-3.1A)
None
None
 1.38A 2qmjA-4cnkA:
undetectable		 2qmjA-4cnkA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ALA A 192
PRO A 196
GLY A 325
THR A 324
VAL A 246
 None
 1.16A 2zifA-4cnkA:
undetectable		 2zifA-4cnkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ALA A 378
PRO A 168
GLY A 164
THR A 173
GLU A 362
 FAD  A1392 ( 3.7A)
None
None
None
FAD  A1392 (-3.5A)
 1.10A 2zifA-4cnkA:
undetectable		 2zifA-4cnkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ALA A 192
PRO A 196
GLY A 325
THR A 324
VAL A 246
 None
 1.10A 2zifB-4cnkA:
undetectable		 2zifB-4cnkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.15A 2zj0A-4cnkA:
2.2		 2zj0A-4cnkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 2zj0B-4cnkA:
2.3		 2zj0B-4cnkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.12A 2zj0C-4cnkA:
undetectable		 2zj0C-4cnkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 3ce6A-4cnkA:
undetectable		 3ce6A-4cnkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 3ce6B-4cnkA:
undetectable		 3ce6B-4cnkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.18A 3ce6C-4cnkA:
undetectable		 3ce6C-4cnkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.01A 3drcA-4cnkA:
undetectable		 3drcA-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.01A 3drcB-4cnkA:
undetectable		 3drcB-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 121
TRP A 153
THR A  29
ILE A   9
THR A 132
 None
 1.10A 3em0B-4cnkA:
undetectable		 3em0B-4cnkA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A 174
ASP A 178
ILE A 179
VAL A 160
VAL A 363
 None
None
GOL  A1401 (-3.9A)
None
None
 1.19A 3fhjA-4cnkA:
undetectable		 3fhjA-4cnkA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A 174
ASP A 178
ILE A 179
VAL A 160
VAL A 363
 None
None
GOL  A1401 (-3.9A)
None
None
 1.19A 3fhjB-4cnkA:
undetectable		 3fhjB-4cnkA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 4 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.28A 3g1uA-4cnkA:
undetectable		 3g1uA-4cnkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.25A 3g1uC-4cnkA:
undetectable		 3g1uC-4cnkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.15A 3glqA-4cnkA:
undetectable		 3glqA-4cnkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.22A 3glqB-4cnkA:
3.0		 3glqB-4cnkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 6 LEU A 257
ILE A 289
ALA A 290
THR A 294
 None
 1.05A 3mdrA-4cnkA:
undetectable		 3mdrA-4cnkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.23A 3n58A-4cnkA:
2.2		 3n58A-4cnkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 7 PHE A 373
THR A 370
ASN A  51
HIS A 225
 None
MEU  A1393 (-4.0A)
FAD  A1392 (-4.2A)
None
 1.08A 3t01A-4cnkA:
undetectable		 3t01A-4cnkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ARG A  49
GLY A 101
VAL A  97
GLU A  98
ASN A  54
 SO4  A1396 (-3.8A)
None
None
None
None
 1.37A 3uayA-4cnkA:
undetectable		 3uayA-4cnkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 HIS A 231
LEU A 227
LEU A 240
ASP A 226
 None
 1.33A 4aqlA-4cnkA:
undetectable		 4aqlA-4cnkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.04A 4dfrB-4cnkA:
undetectable		 4dfrB-4cnkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.90A 4ej1A-4cnkA:
undetectable		 4ej1A-4cnkA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.94A 4fhbA-4cnkA:
undetectable		 4fhbA-4cnkA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.96A 4i13A-4cnkA:
undetectable		 4i13A-4cnkA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 4lvcA-4cnkA:
undetectable		 4lvcA-4cnkA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.18A 4lvcC-4cnkA:
undetectable		 4lvcC-4cnkA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 LEU A  61
LEU A  58
VAL A  75
THR A  53
ILE A  85
 None
 1.30A 4oktA-4cnkA:
undetectable		 4oktA-4cnkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.01A 4p3rA-4cnkA:
undetectable		 4p3rA-4cnkA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 VAL A 323
LEU A 227
ILE A 321
LEU A 242
ALA A 238
 None
 1.02A 4p65B-4cnkA:
undetectable
4p65D-4cnkA:
undetectable
4p65I-4cnkA:
undetectable
4p65J-4cnkA:
undetectable		 4p65B-4cnkA:
7.78
4p65D-4cnkA:
7.78
4p65I-4cnkA:
5.79
4p65J-4cnkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 LEU A 227
VAL A 323
ILE A 321
LEU A 242
ALA A 238
 None
 0.99A 4p65F-4cnkA:
undetectable
4p65H-4cnkA:
undetectable
4p65K-4cnkA:
undetectable
4p65L-4cnkA:
undetectable		 4p65F-4cnkA:
7.78
4p65H-4cnkA:
7.78
4p65K-4cnkA:
5.79
4p65L-4cnkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.01A 4p66A-4cnkA:
undetectable		 4p66A-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 HIS A 185
SER A 172
LEU A 364
THR A 335
SER A 166
 None
FAD  A1392 ( 4.1A)
None
None
FAD  A1392 ( 4.3A)
 1.20A 4pooA-4cnkA:
undetectable		 4pooA-4cnkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 THR A  29
ILE A 159
LEU A  32
THR A  19
SER A  21
 None
 1.35A 4pooA-4cnkA:
undetectable		 4pooA-4cnkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 LEU A 277
LEU A 269
GLU A 310
ALA A 311
LEU A 312
 None
 1.17A 4wg0J-4cnkA:
undetectable
4wg0K-4cnkA:
undetectable
4wg0L-4cnkA:
undetectable		 4wg0J-4cnkA:
3.28
4wg0K-4cnkA:
3.28
4wg0L-4cnkA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 PHE A 333
GLY A 325
LEU A 198
ALA A 192
PHE A 232
 FAD  A1392 (-4.2A)
None
None
None
None
 1.05A 4wnuA-4cnkA:
undetectable		 4wnuA-4cnkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 PHE A 333
GLY A 325
LEU A 198
ALA A 192
PHE A 232
 FAD  A1392 (-4.2A)
None
None
None
None
 1.00A 4wnuC-4cnkA:
undetectable		 4wnuC-4cnkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.99A 4x5gB-4cnkA:
undetectable		 4x5gB-4cnkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.90A 4x5iA-4cnkA:
undetectable		 4x5iA-4cnkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 8 ALA A 360
GLY A 382
ALA A  18
GLY A  15
 None
 0.67A 4zjzA-4cnkA:
undetectable		 4zjzA-4cnkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 GLY A 361
ILE A 375
LEU A 379
GLY A  12
GLY A 174
 FAD  A1392 (-3.2A)
FAD  A1392 (-4.2A)
None
FAD  A1392 (-3.4A)
None
 1.06A 5d4uA-4cnkA:
undetectable		 5d4uA-4cnkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 GLY A 361
ILE A 375
LEU A 379
GLY A  12
GLY A 174
 FAD  A1392 (-3.2A)
FAD  A1392 (-4.2A)
None
FAD  A1392 (-3.4A)
None
 1.06A 5d4uB-4cnkA:
undetectable		 5d4uB-4cnkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 GLY A 361
ILE A 375
LEU A 379
GLY A  12
GLY A 174
 FAD  A1392 (-3.2A)
FAD  A1392 (-4.2A)
None
FAD  A1392 (-3.4A)
None
 1.04A 5d4uC-4cnkA:
undetectable		 5d4uC-4cnkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eeuJ-4cnkA:
undetectable
5eeuK-4cnkA:
undetectable		 5eeuJ-4cnkA:
12.76
5eeuK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.36A 5eeuT-4cnkA:
undetectable
5eeuU-4cnkA:
undetectable		 5eeuT-4cnkA:
12.76
5eeuU-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.83A 5eevA-4cnkA:
undetectable
5eevB-4cnkA:
undetectable		 5eevA-4cnkA:
12.76
5eevB-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eevH-4cnkA:
undetectable
5eevI-4cnkA:
undetectable		 5eevH-4cnkA:
12.76
5eevI-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eevJ-4cnkA:
undetectable
5eevK-4cnkA:
undetectable		 5eevJ-4cnkA:
12.76
5eevK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.36A 5eevT-4cnkA:
undetectable
5eevU-4cnkA:
undetectable		 5eevT-4cnkA:
12.76
5eevU-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.83A 5eewA-4cnkA:
undetectable
5eewB-4cnkA:
undetectable		 5eewA-4cnkA:
12.76
5eewB-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eewH-4cnkA:
undetectable
5eewI-4cnkA:
undetectable		 5eewH-4cnkA:
12.76
5eewI-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eewJ-4cnkA:
undetectable
5eewK-4cnkA:
undetectable		 5eewJ-4cnkA:
12.76
5eewK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.36A 5eewT-4cnkA:
undetectable
5eewU-4cnkA:
undetectable		 5eewT-4cnkA:
12.76
5eewU-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.34A 5eewU-4cnkA:
undetectable
5eewV-4cnkA:
undetectable		 5eewU-4cnkA:
12.76
5eewV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.83A 5eexA-4cnkA:
undetectable
5eexB-4cnkA:
undetectable		 5eexA-4cnkA:
12.76
5eexB-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eexH-4cnkA:
undetectable
5eexI-4cnkA:
undetectable		 5eexH-4cnkA:
12.76
5eexI-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eexJ-4cnkA:
undetectable
5eexK-4cnkA:
undetectable		 5eexJ-4cnkA:
12.76
5eexK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.36A 5eexT-4cnkA:
undetectable
5eexU-4cnkA:
undetectable		 5eexT-4cnkA:
12.76
5eexU-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.82A 5eeyA-4cnkA:
undetectable
5eeyB-4cnkA:
undetectable		 5eeyA-4cnkA:
12.76
5eeyB-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eeyH-4cnkA:
undetectable
5eeyI-4cnkA:
0.4		 5eeyH-4cnkA:
12.76
5eeyI-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eeyJ-4cnkA:
undetectable
5eeyK-4cnkA:
undetectable		 5eeyJ-4cnkA:
12.76
5eeyK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.37A 5eeyT-4cnkA:
undetectable
5eeyU-4cnkA:
undetectable		 5eeyT-4cnkA:
12.76
5eeyU-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.35A 5eeyU-4cnkA:
undetectable
5eeyV-4cnkA:
undetectable		 5eeyU-4cnkA:
12.76
5eeyV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.82A 5eezA-4cnkA:
undetectable
5eezB-4cnkA:
0.5		 5eezA-4cnkA:
12.76
5eezB-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eezH-4cnkA:
undetectable
5eezI-4cnkA:
0.4		 5eezH-4cnkA:
12.76
5eezI-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5eezJ-4cnkA:
undetectable
5eezK-4cnkA:
undetectable		 5eezJ-4cnkA:
12.76
5eezK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.37A 5eezT-4cnkA:
undetectable
5eezU-4cnkA:
undetectable		 5eezT-4cnkA:
12.76
5eezU-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.82A 5ef0A-4cnkA:
undetectable
5ef0B-4cnkA:
undetectable		 5ef0A-4cnkA:
12.76
5ef0B-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef0C-4cnkA:
undetectable
5ef0D-4cnkA:
undetectable		 5ef0C-4cnkA:
12.76
5ef0D-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef0H-4cnkA:
undetectable
5ef0I-4cnkA:
0.4		 5ef0H-4cnkA:
12.76
5ef0I-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.35A 5ef0J-4cnkA:
undetectable
5ef0K-4cnkA:
undetectable		 5ef0J-4cnkA:
12.76
5ef0K-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.37A 5ef0T-4cnkA:
undetectable
5ef0U-4cnkA:
undetectable		 5ef0T-4cnkA:
12.76
5ef0U-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.82A 5ef1A-4cnkA:
undetectable
5ef1B-4cnkA:
undetectable		 5ef1A-4cnkA:
12.76
5ef1B-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef1B-4cnkA:
undetectable
5ef1C-4cnkA:
undetectable		 5ef1B-4cnkA:
12.76
5ef1C-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef1C-4cnkA:
undetectable
5ef1D-4cnkA:
undetectable		 5ef1C-4cnkA:
12.76
5ef1D-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.35A 5ef1H-4cnkA:
undetectable
5ef1I-4cnkA:
0.4		 5ef1H-4cnkA:
12.76
5ef1I-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.35A 5ef1J-4cnkA:
undetectable
5ef1K-4cnkA:
undetectable		 5ef1J-4cnkA:
12.76
5ef1K-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.37A 5ef1T-4cnkA:
undetectable
5ef1U-4cnkA:
undetectable		 5ef1T-4cnkA:
12.76
5ef1U-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.35A 5ef1U-4cnkA:
undetectable
5ef1V-4cnkA:
undetectable		 5ef1U-4cnkA:
12.76
5ef1V-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.82A 5ef2A-4cnkA:
undetectable
5ef2B-4cnkA:
undetectable		 5ef2A-4cnkA:
12.76
5ef2B-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef2B-4cnkA:
undetectable
5ef2C-4cnkA:
undetectable		 5ef2B-4cnkA:
12.76
5ef2C-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef2C-4cnkA:
undetectable
5ef2D-4cnkA:
undetectable		 5ef2C-4cnkA:
12.76
5ef2D-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.35A 5ef2J-4cnkA:
undetectable
5ef2K-4cnkA:
undetectable		 5ef2J-4cnkA:
12.76
5ef2K-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.37A 5ef2T-4cnkA:
undetectable
5ef2U-4cnkA:
undetectable		 5ef2T-4cnkA:
12.76
5ef2U-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.35A 5ef2U-4cnkA:
undetectable
5ef2V-4cnkA:
undetectable		 5ef2U-4cnkA:
12.76
5ef2V-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.82A 5ef3A-4cnkA:
undetectable
5ef3B-4cnkA:
undetectable		 5ef3A-4cnkA:
12.76
5ef3B-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef3B-4cnkA:
undetectable
5ef3C-4cnkA:
undetectable		 5ef3B-4cnkA:
12.76
5ef3C-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.34A 5ef3C-4cnkA:
undetectable
5ef3D-4cnkA:
undetectable		 5ef3C-4cnkA:
12.76
5ef3D-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.35A 5ef3H-4cnkA:
undetectable
5ef3I-4cnkA:
undetectable		 5ef3H-4cnkA:
12.76
5ef3I-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 9 SER A  23
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 1.35A 5ef3J-4cnkA:
undetectable
5ef3K-4cnkA:
undetectable		 5ef3J-4cnkA:
12.76
5ef3K-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.34A 5ef3A-4cnkA:
undetectable
5ef3K-4cnkA:
undetectable		 5ef3A-4cnkA:
12.76
5ef3K-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.37A 5ef3T-4cnkA:
undetectable
5ef3U-4cnkA:
undetectable		 5ef3T-4cnkA:
12.76
5ef3U-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 10 ALA A  18
THR A  29
THR A   6
ILE A 159
SER A  23
 None
 1.35A 5ef3U-4cnkA:
undetectable
5ef3V-4cnkA:
undetectable		 5ef3U-4cnkA:
12.76
5ef3V-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 4 VAL A 323
GLU A 250
GLY A 325
LEU A 197
 None
 1.21A 5g5gC-4cnkA:
undetectable		 5g5gC-4cnkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 4 CYH A  50
PHE A 104
ILE A  84
GLY A 372
 None
None
None
FAD  A1392 (-3.2A)
 1.03A 5hesB-4cnkA:
undetectable		 5hesB-4cnkA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		3 / 3 VAL A  75
LEU A 117
MET A  16
 None
 0.53A 5ikrA-4cnkA:
undetectable		 5ikrA-4cnkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 0.97A 5ujxA-4cnkA:
undetectable		 5ujxA-4cnkA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 12 LEU A  42
GLY A 171
LEU A  38
GLY A  11
GLY A  12
 None
FAD  A1392 (-3.5A)
None
FAD  A1392 ( 4.6A)
FAD  A1392 (-3.4A)
 0.94A 5wyqA-4cnkA:
undetectable		 5wyqA-4cnkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ILE A 313
ALA A 311
LEU A 304
LEU A 281
ILE A 316
 None
 1.07A 5z6mA-4cnkA:
undetectable		 5z6mA-4cnkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.23A 6aphA-4cnkA:
2.3		 6aphA-4cnkA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 4 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.18A 6f3nA-4cnkA:
2.4		 6f3nA-4cnkA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 4 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.18A 6f3nC-4cnkA:
2.3		 6f3nC-4cnkA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 4 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 6f3nD-4cnkA:
2.3		 6f3nD-4cnkA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 6gbnA-4cnkA:
2.2		 6gbnA-4cnkA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 6gbnB-4cnkA:
undetectable		 6gbnB-4cnkA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.17A 6gbnC-4cnkA:
2.1		 6gbnC-4cnkA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 GLN A 156
THR A   6
THR A 348
HIS A 389
 None
 1.15A 6gbnD-4cnkA:
undetectable		 6gbnD-4cnkA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 5 LEU A 349
THR A 381
THR A 161
GLY A 361
 None
None
None
FAD  A1392 (-3.2A)
 1.26A 6gtqA-4cnkA:
undetectable		 6gtqA-4cnkA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
ALA A 360
ALA A 385
GLY A  11
GLY A  10
 None
None
None
FAD  A1392 ( 4.6A)
FAD  A1392 (-3.0A)
 0.89A 6hwdK-4cnkA:
undetectable
6hwdL-4cnkA:
undetectable		 6hwdK-4cnkA:
12.20
6hwdL-4cnkA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		5 / 11 ALA A  18
ALA A 360
ALA A 385
GLY A  11
GLY A  10
 None
None
None
FAD  A1392 ( 4.6A)
FAD  A1392 (-3.0A)
 0.89A 6hwdY-4cnkA:
undetectable
6hwdZ-4cnkA:
undetectable		 6hwdY-4cnkA:
12.20
6hwdZ-4cnkA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cnk L-AMINO ACID OXIDASE
(Streptococcus
cristatus) 		4 / 6 ARG A 288
GLN A 295
LEU A 206
PHE A 229
 None
 1.31A 6nmpC-4cnkA:
undetectable
6nmpJ-4cnkA:
undetectable		 6nmpC-4cnkA:
20.76
6nmpJ-4cnkA:
10.57