SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.08A 1am6A-4cnsA:
undetectable		 1am6A-4cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.05A 1azmA-4cnsA:
undetectable		 1azmA-4cnsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 VAL A 364
TRP A 366
TRP A 412
 None
 1.43A 1c4dA-4cnsA:
undetectable
1c4dB-4cnsA:
undetectable		 1c4dA-4cnsA:
4.08
1c4dB-4cnsA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 LEU A 188
LEU A 191
GLY A 192
VAL A 161
LEU A 250
 None
 1.12A 1gs4A-4cnsA:
undetectable		 1gs4A-4cnsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 THR A 384
LEU A 328
GLY A 330
LEU A 283
 None
 0.97A 1gtiD-4cnsA:
undetectable		 1gtiD-4cnsA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 THR A 384
LEU A 328
GLY A 330
LEU A 283
 None
 0.94A 1gtiE-4cnsA:
undetectable		 1gtiE-4cnsA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 GLU A 232
ILE A 264
PRO A 278
LEU A 326
 None
 0.82A 1hmyA-4cnsA:
undetectable		 1hmyA-4cnsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
EDO  A1491 ( 4.9A)
None
None
None
 0.96A 1r9oA-4cnsA:
undetectable		 1r9oA-4cnsA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 10 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.47A 1wygA-4cnsA:
undetectable		 1wygA-4cnsA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.31A 2avoB-4cnsA:
undetectable		 2avoB-4cnsA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
ILE A  19
PRO A  67
ILE A  24
 None
 1.49A 2bpxB-4cnsA:
undetectable		 2bpxB-4cnsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.32A 2bpxB-4cnsA:
undetectable		 2bpxB-4cnsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 HIS A  75
HIS A  73
HIS A 107
VAL A 109
 None
 0.63A 2gehA-4cnsA:
undetectable		 2gehA-4cnsA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 THR A 280
THR A 355
THR A  85
ASP A  88
 None
 1.22A 2okcB-4cnsA:
undetectable		 2okcB-4cnsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 PRO A 220
ILE A 217
ASN A 347
LEU A 213
 None
 1.37A 2wekB-4cnsA:
undetectable		 2wekB-4cnsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 PRO A 306
GLU A 221
TYR A 290
 None
 0.73A 2zmbA-4cnsA:
undetectable		 2zmbA-4cnsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 10 GLU A 435
GLY A 357
ALA A 332
PHE A 301
LEU A 307
 None
None
MG  A1495 ( 3.9A)
None
None
 1.21A 3a3yA-4cnsA:
undetectable		 3a3yA-4cnsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 9 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.45A 3ax7B-4cnsA:
undetectable		 3ax7B-4cnsA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 11 HIS A  75
HIS A  73
HIS A 107
ALA A 169
THR A 253
 None
None
None
CL  A1493 ( 3.7A)
None
 1.24A 3mdzA-4cnsA:
undetectable		 3mdzA-4cnsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 8 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.46A 3ns1L-4cnsA:
undetectable		 3ns1L-4cnsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 9 GLY A  21
GLY A  22
TYR A  32
GLU A  59
ILE A  19
 None
 1.48A 3owxA-4cnsA:
undetectable		 3owxA-4cnsA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 SER A 131
VAL A 358
ILE A 104
THR A  85
 None
 1.01A 3tneB-4cnsA:
undetectable		 3tneB-4cnsA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 LYS A  12
ARG A 397
LEU A  41
 None
 1.27A 3v4tE-4cnsA:
undetectable		 3v4tE-4cnsA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 5 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.79A 3wrkA-4cnsA:
undetectable		 3wrkA-4cnsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 LEU A 326
SER A 323
ASP A 315
TYR A 316
 None
 1.03A 4drjB-4cnsA:
undetectable		 4drjB-4cnsA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 HIS A 223
TRP A 295
SER A 304
 None
 1.14A 4lrhD-4cnsA:
undetectable		 4lrhD-4cnsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 TYR A  32
VAL A  65
ILE A  35
ILE A  45
 None
 0.91A 4lv9B-4cnsA:
2.3		 4lv9B-4cnsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 ASP A 406
ALA A 136
TYR A 135
ASP A 408
 None
 1.05A 4mdaA-4cnsA:
undetectable		 4mdaA-4cnsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 ASP A 406
ALA A 136
TYR A 135
ASP A 408
 None
 1.02A 4mdbA-4cnsA:
undetectable		 4mdbA-4cnsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 ILE A 184
HIS A 107
PHE A 185
THR A 253
 None
 0.92A 4n16A-4cnsA:
undetectable		 4n16A-4cnsA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 5 TYR A 477
GLY A 324
ASP A 325
VAL A 236
 None
 0.89A 4nkvD-4cnsA:
undetectable		 4nkvD-4cnsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 GLY A 276
VAL A 236
GLU A 232
SER A 282
ILE A 317
 None
 1.16A 4pd5A-4cnsA:
undetectable		 4pd5A-4cnsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 359
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.82A 4q15A-4cnsA:
undetectable		 4q15A-4cnsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.56A 4q15A-4cnsA:
undetectable		 4q15A-4cnsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 359
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.82A 4q15B-4cnsA:
undetectable		 4q15B-4cnsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.55A 4q15B-4cnsA:
undetectable		 4q15B-4cnsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 11 LEU A 283
ILE A  66
GLY A  69
VAL A 364
ILE A 365
 None
 0.97A 4qgiB-4cnsA:
undetectable		 4qgiB-4cnsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 359
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.77A 4ydqB-4cnsA:
undetectable		 4ydqB-4cnsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
EDO  A1492 ( 4.9A)
None
 0.58A 4ydqB-4cnsA:
undetectable		 4ydqB-4cnsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 9 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
EDO  A1490 (-3.2A)
None
None
EDO  A1491 ( 3.8A)
 1.20A 5entC-4cnsA:
undetectable		 5entC-4cnsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  98
ASP A 408
LYS A 398
GLY A  69
SER A 385
 None
 1.32A 5hfjE-4cnsA:
undetectable		 5hfjE-4cnsA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  17
MET A  37
ILE A 411
ALA A  60
ILE A 447
 None
 1.32A 5nm5B-4cnsA:
2.4		 5nm5B-4cnsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.24A 5os7A-4cnsA:
undetectable		 5os7A-4cnsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 GLU A 230
ALA A 233
LEU A 231
SER A 259
 EDO  A1490 (-4.5A)
EDO  A1490 (-3.6A)
None
EDO  A1490 (-3.2A)
 1.04A 5phhA-4cnsA:
undetectable		 5phhA-4cnsA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 HIS A  75
HIS A  73
HIS A 107
VAL A 109
 None
 0.87A 5tt3H-4cnsA:
undetectable		 5tt3H-4cnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 ALA A 195
THR A 253
TRP A 144
ALA A 169
 None
None
None
CL  A1493 ( 3.7A)
 0.99A 5x2tI-4cnsA:
undetectable
5x2tJ-4cnsA:
undetectable
5x2tK-4cnsA:
undetectable
5x2tL-4cnsA:
undetectable		 5x2tI-4cnsA:
14.53
5x2tJ-4cnsA:
13.33
5x2tK-4cnsA:
14.53
5x2tL-4cnsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 LEU A 444
GLY A  62
ILE A  35
VAL A  25
ILE A 411
 None
 0.93A 6dh6A-4cnsA:
undetectable		 6dh6A-4cnsA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 11 GLU A 360
SER A 427
ALA A 428
THR A 338
ALA A 296
 None
 1.40A 6efnA-4cnsA:
5.2		 6efnA-4cnsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.24A 6gmdB-4cnsA:
undetectable		 6gmdB-4cnsA:
21.89