SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cnt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.10A 1am6A-4cntA:
undetectable		 1am6A-4cntA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 HIS A  75
HIS A  73
HIS A 107
THR A 253
 None
 1.06A 1azmA-4cntA:
undetectable		 1azmA-4cntA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 VAL A 364
TRP A 366
TRP A 412
 None
 1.44A 1c4dA-4cntA:
undetectable
1c4dB-4cntA:
undetectable		 1c4dA-4cntA:
4.08
1c4dB-4cntA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 11 HIS A 138
HIS A 107
HIS A  73
LEU A 328
THR A 253
 None
 1.31A 1dmyA-4cntA:
undetectable		 1dmyA-4cntA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 LEU A 188
LEU A 191
GLY A 192
VAL A 161
LEU A 250
 None
 1.10A 1gs4A-4cntA:
undetectable		 1gs4A-4cntA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 THR A 384
LEU A 328
GLY A 330
LEU A 283
 None
 0.94A 1gtiD-4cntA:
undetectable		 1gtiD-4cntA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 THR A 384
LEU A 328
GLY A 330
LEU A 283
 None
 0.96A 1gtiE-4cntA:
undetectable		 1gtiE-4cntA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 GLU A 232
ILE A 264
PRO A 278
LEU A 326
 None
 0.81A 1hmyA-4cntA:
undetectable		 1hmyA-4cntA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 VAL A 255
ILE A 240
MET A 168
ALA A 260
LEU A 326
 None
 0.95A 1r9oA-4cntA:
undetectable		 1r9oA-4cntA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 10 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 1wygA-4cntA:
undetectable		 1wygA-4cntA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.29A 2avoB-4cntA:
undetectable		 2avoB-4cntA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 HIS A  75
HIS A  73
HIS A 107
VAL A 109
 None
 0.66A 2gehA-4cntA:
undetectable		 2gehA-4cntA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
ILE A  19
PRO A  67
ILE A  24
 None
 1.48A 2qakA-4cntA:
undetectable		 2qakA-4cntA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.34A 2qakA-4cntA:
undetectable		 2qakA-4cntA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
VAL A  65
ILE A  19
ILE A  24
 None
 1.31A 2r5pB-4cntA:
undetectable		 2r5pB-4cntA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 PRO A 220
ILE A 217
ASN A 347
LEU A 213
 None
 1.36A 2wekB-4cntA:
undetectable		 2wekB-4cntA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 PRO A 306
GLU A 221
TYR A 290
 None
 0.79A 2zmbA-4cntA:
undetectable		 2zmbA-4cntA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 10 GLU A 435
GLY A 357
ALA A 332
PHE A 301
LEU A 307
 None
 1.20A 3a3yA-4cntA:
undetectable		 3a3yA-4cntA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 9 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.41A 3ax7B-4cntA:
undetectable		 3ax7B-4cntA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
ILE A  19
PRO A  67
ILE A  24
 None
 1.46A 3d1xA-4cntA:
undetectable		 3d1xA-4cntA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
ILE A  19
PRO A  67
ILE A  24
 None
 1.47A 3d1yA-4cntA:
undetectable		 3d1yA-4cntA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 11 HIS A  75
HIS A  73
HIS A 107
ALA A 169
THR A 253
 None
 1.25A 3mdzA-4cntA:
undetectable		 3mdzA-4cntA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 GLU A 232
THR A 313
ALA A 260
ALA A 261
 None
 1.21A 3ns1C-4cntA:
undetectable		 3ns1C-4cntA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 8 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.41A 3ns1L-4cntA:
undetectable		 3ns1L-4cntA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 LEU A 444
GLY A  62
ILE A  35
VAL A  25
ILE A 411
 None
 1.07A 3oxxA-4cntA:
undetectable		 3oxxA-4cntA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 7 SER A 131
VAL A 358
ILE A 104
THR A  85
 None
 1.06A 3tneB-4cntA:
undetectable		 3tneB-4cntA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 SER A 282
ASP A  71
ASP A 106
 None
 0.91A 3uj7A-4cntA:
undetectable		 3uj7A-4cntA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 5 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.80A 3wrkA-4cntA:
undetectable		 3wrkA-4cntA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 GLY A 466
LEU A 454
HIS A 460
GLY A 100
ASP A 408
 None
 1.16A 4blvB-4cntA:
undetectable		 4blvB-4cntA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 SER A 385
GLN A 196
THR A 253
ILE A 391
HIS A  73
 None
 1.25A 4c49A-4cntA:
undetectable		 4c49A-4cntA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 LEU A 326
SER A 323
ASP A 315
TYR A 316
 None
 1.05A 4drjB-4cntA:
undetectable		 4drjB-4cntA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 ASP A  28
ASN A 378
THR A 384
GLY A 399
 None
 1.01A 4fo4A-4cntA:
5.3		 4fo4A-4cntA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 ASP A 406
ALA A 136
TYR A 135
ASP A 408
 None
 0.98A 4mdaA-4cntA:
undetectable		 4mdaA-4cntA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 ASP A 406
ALA A 136
TYR A 135
ASP A 408
 None
 0.95A 4mdbA-4cntA:
undetectable		 4mdbA-4cntA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 ILE A 184
HIS A 107
PHE A 185
THR A 253
 None
 0.90A 4n16A-4cntA:
undetectable		 4n16A-4cntA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 5 TYR A 477
GLY A 324
ASP A 325
VAL A 236
 None
 0.87A 4nkvD-4cntA:
undetectable		 4nkvD-4cntA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
 0.65A 4q15A-4cntA:
undetectable		 4q15A-4cntA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
 0.66A 4q15B-4cntA:
undetectable		 4q15B-4cntA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 SER A 407
ILE A 401
ASP A  28
GLN A  29
ILE A  24
 None
 1.32A 4uroB-4cntA:
undetectable		 4uroB-4cntA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 None
 0.62A 4ydqB-4cntA:
undetectable		 4ydqB-4cntA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 5 ILE A 391
ILE A 105
TYR A 251
GLU A 277
 None
 1.16A 4zzcE-4cntA:
undetectable		 4zzcE-4cntA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 LEU A 328
ASP A 476
ILE A 240
PHE A 275
TYR A 477
 None
 1.40A 5dlvA-4cntA:
undetectable		 5dlvA-4cntA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 9 SER A 282
SER A 259
GLU A 229
ILE A 264
ALA A 267
 None
 1.17A 5entC-4cntA:
undetectable		 5entC-4cntA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  46
ALA A  33
ASP A  34
ILE A  19
PRO A  67
ILE A  24
 None
 1.44A 5kqxA-4cntA:
undetectable		 5kqxA-4cntA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.38A 5os7A-4cntA:
undetectable		 5os7A-4cntA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 6 GLU A 230
ALA A 233
LEU A 231
SER A 259
 None
 0.99A 5phhA-4cntA:
undetectable		 5phhA-4cntA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 HIS A  75
HIS A  73
HIS A 107
VAL A 109
 None
 0.88A 5tt3H-4cntA:
undetectable		 5tt3H-4cntA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		4 / 8 ALA A 195
THR A 253
TRP A 144
ALA A 169
 None
None
EDO  A1497 (-4.2A)
None
 1.02A 5x2tI-4cntA:
undetectable
5x2tJ-4cntA:
undetectable
5x2tK-4cntA:
undetectable
5x2tL-4cntA:
undetectable		 5x2tI-4cntA:
14.39
5x2tJ-4cntA:
13.03
5x2tK-4cntA:
14.39
5x2tL-4cntA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 12 LEU A 444
GLY A  62
ILE A  35
VAL A  25
ILE A 411
 None
 0.96A 6dh6A-4cntA:
undetectable		 6dh6A-4cntA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		5 / 11 GLU A 360
SER A 427
ALA A 428
THR A 338
ALA A 296
 None
 1.37A 6efnA-4cntA:
5.4		 6efnA-4cntA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens) 		3 / 3 HIS A 289
SER A 292
LYS A 297
 None
 1.38A 6gmdB-4cntA:
undetectable		 6gmdB-4cntA:
20.10