SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4co6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 6 LEU A 175
THR A 181
ALA A 179
LEU A 221
 None
 1.13A 1etb2-4co6A:
undetectable		 1etb2-4co6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 LEU A 297
TYR A 301
GLY A 266
GLY A 274
LEU A 275
 None
 1.01A 1fe2A-4co6A:
undetectable		 1fe2A-4co6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 LEU A 297
TYR A 301
GLY A 266
GLY A 274
LEU A 275
 None
 0.95A 1igxA-4co6A:
undetectable		 1igxA-4co6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 SER A  78
TRP A 173
GLU A 169
LEU A  87
ILE A 234
 None
 1.23A 1kyvA-4co6A:
undetectable
1kyvE-4co6A:
undetectable		 1kyvA-4co6A:
20.34
1kyvE-4co6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 SER A  78
TRP A 173
GLU A 169
LEU A  87
ILE A 234
 None
 1.21A 1kyvD-4co6A:
undetectable
1kyvE-4co6A:
undetectable		 1kyvD-4co6A:
20.34
1kyvE-4co6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 5 LEU A  76
ILE A 172
LEU A 175
ARG A 218
 None
 0.93A 2byoA-4co6A:
undetectable		 2byoA-4co6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 5 PHE A 333
THR A 277
LEU A 275
ALA A 334
 None
 1.37A 2e1qD-4co6A:
undetectable		 2e1qD-4co6A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		3 / 3 GLN A 200
LYS A 201
VAL A 203
 None
 0.92A 2jfaB-4co6A:
undetectable		 2jfaB-4co6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 7 ALA A 269
THR A 270
ALA A 334
PRO A 324
 None
 0.90A 2ql8A-4co6A:
undetectable
2ql8B-4co6A:
undetectable		 2ql8A-4co6A:
17.95
2ql8B-4co6A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 6 ARG A 193
THR A 167
ALA A 170
PRO A 205
 None
 0.98A 2ql8A-4co6A:
undetectable
2ql8B-4co6A:
undetectable		 2ql8A-4co6A:
17.95
2ql8B-4co6A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 8 LEU A 221
LEU A 175
LYS A 178
ALA A 179
 None
 0.92A 2wekA-4co6A:
undetectable		 2wekA-4co6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4co6 PHOSPHOPROTEIN
(Nipah
henipavirus) 		4 / 7 GLY D  -1
ALA D   0
MET D   1
LEU D   4
 None
 0.52A 2wekB-4co6D:
undetectable		 2wekB-4co6D:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 GLY A 305
ILE A 318
LEU A 314
LEU A 313
VAL A 232
 None
 1.02A 3adsB-4co6A:
undetectable		 3adsB-4co6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 GLY A 305
ILE A 318
LEU A 314
LEU A 313
VAL A 232
 None
 1.00A 3adxB-4co6A:
undetectable		 3adxB-4co6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		3 / 3 LEU A  92
GLU A  98
ILE A  35
 None
 0.59A 3czhA-4co6A:
undetectable		 3czhA-4co6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 ILE A 172
ALA A  73
LEU A  76
LEU A 209
ILE A  97
 None
 1.03A 3ozwB-4co6A:
undetectable		 3ozwB-4co6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 LEU A 221
LEU A 175
LEU A 214
ILE A  59
ILE A 172
 None
 1.07A 4a7aB-4co6A:
undetectable		 4a7aB-4co6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 5 ILE A 155
LEU A 161
GLU A  50
VAL A 104
 None
 1.02A 4nkxB-4co6A:
undetectable		 4nkxB-4co6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 SER A  67
ALA A  65
GLY A 127
ALA A  64
ILE A 131
 None
 1.15A 5eeuI-4co6A:
undetectable
5eeuJ-4co6A:
undetectable		 5eeuI-4co6A:
14.58
5eeuJ-4co6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 SER A  67
ALA A  65
GLY A 127
ALA A  64
ILE A 131
 None
 1.15A 5eevI-4co6A:
undetectable
5eevJ-4co6A:
undetectable		 5eevI-4co6A:
14.58
5eevJ-4co6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		5 / 12 SER A  67
ALA A  65
GLY A 127
ALA A  64
ILE A 131
 None
 1.15A 5eewI-4co6A:
undetectable
5eewJ-4co6A:
undetectable		 5eewI-4co6A:
14.58
5eewJ-4co6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4co6 NUCLEOPROTEIN
PHOSPHOPROTEIN
(Nipah
henipavirus;
Nipah
henipavirus) 		3 / 3 LEU A 362
TYR D  28
SER D  37
 None
CL  A1374 (-4.7A)
None
 0.72A 5iktA-4co6A:
0.5		 5iktA-4co6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4co6 NUCLEOPROTEIN
PHOSPHOPROTEIN
(Nipah
henipavirus) 		4 / 6 PHE A 273
THR A 277
ASP D   9
GLY D  10
 None
 1.17A 5mraA-4co6A:
undetectable
5mraB-4co6A:
undetectable		 5mraA-4co6A:
17.90
5mraB-4co6A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4co6 NUCLEOPROTEIN
(Nipah
henipavirus) 		4 / 7 ILE A 174
LEU A 175
MET A 217
LEU A 221
 None
 1.01A 5u4sA-4co6A:
undetectable		 5u4sA-4co6A:
21.55