SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A  56
HIS A  60
HIS A  54
HIS A  50
 ZN  A 401 ( 2.5A)
ZN  A 401 ( 4.8A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
 1.23A 1ei6A-4cobA:
undetectable		 1ei6A-4cobA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 160
HIS A 161
VAL A 164
 None
ZN  A 401 (-3.4A)
None
 0.37A 1lqtB-4cobA:
undetectable		 1lqtB-4cobA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 160
HIS A 161
VAL A 164
 None
ZN  A 401 (-3.4A)
None
 0.38A 1lquB-4cobA:
undetectable		 1lquB-4cobA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 177
ALA A 204
GLY A 174
LEU A 142
LEU A 187
 None
 1.14A 1nr6A-4cobA:
undetectable		 1nr6A-4cobA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 138
VAL A 140
VAL A 108
LEU A 110
ILE A 127
 None
 1.08A 3gwxB-4cobA:
undetectable		 3gwxB-4cobA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 109
LEU A 187
CYH A  80
SER A 106
 None
 0.87A 3lm8B-4cobA:
undetectable
3lm8D-4cobA:
undetectable		 3lm8B-4cobA:
21.37
3lm8D-4cobA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 109
LEU A 187
CYH A  80
SER A 106
 None
 0.90A 3lm8A-4cobA:
undetectable
3lm8C-4cobA:
undetectable		 3lm8A-4cobA:
21.37
3lm8C-4cobA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 109
LEU A 187
CYH A  80
SER A 106
 None
 0.84A 3lm8B-4cobA:
undetectable
3lm8D-4cobA:
undetectable		 3lm8B-4cobA:
21.37
3lm8D-4cobA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 176
ILE A 145
LEU A 172
TYR A  76
ALA A 170
 None
 1.40A 5fctB-4cobA:
undetectable		 5fctB-4cobA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  56
HIS A  60
HIS A 161
HIS A  54
 ZN  A 401 ( 2.5A)
ZN  A 401 ( 4.8A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.73A 5ncdA-4cobA:
undetectable
5ncdD-4cobA:
undetectable		 5ncdA-4cobA:
22.51
5ncdD-4cobA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  56
HIS A  60
HIS A 161
HIS A  54
 ZN  A 401 ( 2.5A)
ZN  A 401 ( 4.8A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.70A 5ncdB-4cobA:
undetectable
5ncdC-4cobA:
undetectable		 5ncdB-4cobA:
22.51
5ncdC-4cobA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
HIS A  60
HIS A 161
HIS A  54
 ZN  A 401 ( 2.5A)
ZN  A 401 ( 4.8A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.85A 5nekB-4cobA:
undetectable		 5nekB-4cobA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
HIS A  60
HIS A 161
HIS A  54
 ZN  A 401 ( 2.5A)
ZN  A 401 ( 4.8A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.74A 5nekD-4cobA:
undetectable		 5nekD-4cobA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  56
HIS A  60
HIS A 161
HIS A  54
 ZN  A 401 ( 2.5A)
ZN  A 401 ( 4.8A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.77A 5nelA-4cobA:
undetectable
5nelD-4cobA:
undetectable		 5nelA-4cobA:
22.51
5nelD-4cobA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4cob KYNURENINE
FORMAMIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 164
ALA A 170
PRO A  58
ARG A  62
LEU A  66
 None
 1.24A 5syfB-4cobA:
undetectable		 5syfB-4cobA:
21.31