SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cog'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 159
HIS A 160
VAL A 163
 None
ZN  A 401 ( 3.3A)
None
 0.44A 1lqtB-4cogA:
undetectable		 1lqtB-4cogA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 159
HIS A 160
VAL A 163
 None
ZN  A 401 ( 3.3A)
None
 0.43A 1lquB-4cogA:
undetectable		 1lquB-4cogA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		4 / 6 ASP A  54
HIS A  58
HIS A 160
HIS A  52
 ZN  A 401 (-2.5A)
GOL  A1213 ( 3.7A)
ZN  A 401 ( 3.3A)
CD  A 402 ( 3.4A)
 0.77A 5ncdA-4cogA:
undetectable
5ncdD-4cogA:
undetectable		 5ncdA-4cogA:
24.81
5ncdD-4cogA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		4 / 6 ASP A  54
HIS A  58
HIS A 160
HIS A  52
 ZN  A 401 (-2.5A)
GOL  A1213 ( 3.7A)
ZN  A 401 ( 3.3A)
CD  A 402 ( 3.4A)
 0.74A 5ncdB-4cogA:
undetectable
5ncdC-4cogA:
undetectable		 5ncdB-4cogA:
24.81
5ncdC-4cogA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		4 / 8 ASP A  54
HIS A  58
HIS A 160
HIS A  52
 ZN  A 401 (-2.5A)
GOL  A1213 ( 3.7A)
ZN  A 401 ( 3.3A)
CD  A 402 ( 3.4A)
 0.89A 5nekB-4cogA:
undetectable		 5nekB-4cogA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		4 / 8 ASP A  54
HIS A  58
HIS A 160
HIS A  52
 ZN  A 401 (-2.5A)
GOL  A1213 ( 3.7A)
ZN  A 401 ( 3.3A)
CD  A 402 ( 3.4A)
 0.79A 5nekD-4cogA:
undetectable		 5nekD-4cogA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		4 / 6 ASP A  54
HIS A  58
HIS A 160
HIS A  52
 ZN  A 401 (-2.5A)
GOL  A1213 ( 3.7A)
ZN  A 401 ( 3.3A)
CD  A 402 ( 3.4A)
 0.82A 5nelA-4cogA:
undetectable
5nelD-4cogA:
undetectable		 5nelA-4cogA:
24.81
5nelD-4cogA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		4 / 5 ASP A 145
PRO A  16
GLU A 117
ARG A 113
 None
 1.30A 5uxcA-4cogA:
undetectable		 5uxcA-4cogA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		4 / 6 TYR A  59
VAL A 126
GLU A 172
ALA A  55
 None
None
ZN  A 401 (-2.0A)
None
 1.05A 6djzB-4cogA:
undetectable		 6djzB-4cogA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4cog KYNURENINE
FORMAMIDASE
(Burkholderia
cenocepacia) 		5 / 10 THR A 146
GLY A 143
LEU A 108
SER A 154
VAL A 139
 None
 1.31A 6gnfC-4cogA:
undetectable		 6gnfC-4cogA:
18.93