SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 6 ALA A 193
LYS A 196
ASP A 200
ALA A 201
 None
 0.32A 1iwhA-4cokA:
undetectable		 1iwhA-4cokA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 ALA A 222
GLY A 224
ARG A  62
LEU A  92
GLU A  90
 None
 1.27A 1mj2A-4cokA:
undetectable
1mj2B-4cokA:
undetectable		 1mj2A-4cokA:
11.16
1mj2B-4cokA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 11 ARG A  62
LEU A  92
GLU A  90
ALA A 222
GLY A 224
 None
 1.30A 1mjqA-4cokA:
undetectable
1mjqB-4cokA:
undetectable		 1mjqA-4cokA:
11.16
1mjqB-4cokA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 10 ARG A  62
LEU A  92
GLU A  90
ALA A 222
GLY A 224
 None
 1.28A 1mjqC-4cokA:
undetectable
1mjqD-4cokA:
undetectable		 1mjqC-4cokA:
11.16
1mjqD-4cokA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 11 ARG A  62
LEU A  92
GLU A  90
ALA A 222
GLY A 224
 None
 1.27A 1mjqI-4cokA:
undetectable
1mjqJ-4cokA:
undetectable		 1mjqI-4cokA:
11.16
1mjqJ-4cokA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 7 GLN A 369
ALA A 504
PHE A 459
ARG A 518
 None
None
None
SO4  A1556 (-3.9A)
 1.37A 1t9wA-4cokA:
undetectable		 1t9wA-4cokA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 11 GLU A 403
GLY A 420
GLY A  59
ALA A 424
ALA A 425
 None
 1.03A 1x7pA-4cokA:
undetectable
1x7pB-4cokA:
2.3		 1x7pA-4cokA:
20.28
1x7pB-4cokA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 5 TRP A 298
PRO A 299
LEU A 215
GLY A 217
 None
 1.45A 1ya4C-4cokA:
1.7		 1ya4C-4cokA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 10 ILE A  16
ALA A  14
ILE A  97
PRO A  93
ILE A  95
 None
 1.25A 2dm6A-4cokA:
undetectable
2dm6B-4cokA:
undetectable		 2dm6A-4cokA:
21.37
2dm6B-4cokA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 ALA A  87
LEU A  84
ALA A  83
GLN A  44
ILE A  70
 None
 1.01A 2jjpA-4cokA:
undetectable		 2jjpA-4cokA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 ASN A 421
LEU A 423
GLY A 420
VAL A 446
THR A 381
 None
 1.05A 2q7lA-4cokA:
undetectable		 2q7lA-4cokA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 6 LEU A  13
LEU A   9
ILE A  16
ARG A  12
 None
 0.95A 2rlfC-4cokA:
undetectable
2rlfD-4cokA:
undetectable		 2rlfC-4cokA:
6.11
2rlfD-4cokA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 SER A 218
PRO A 285
ALA A 244
VAL A 274
TYR A 261
 None
 1.07A 2zifB-4cokA:
undetectable		 2zifB-4cokA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 6 THR A 335
LEU A 236
VAL A 212
VAL A 314
 None
 1.09A 2zuhA-4cokA:
undetectable		 2zuhA-4cokA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 6 ASN A 169
ALA A 103
HIS A 106
ASP A 105
 None
 1.22A 3aruA-4cokA:
undetectable		 3aruA-4cokA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		3 / 3 MET A 406
VAL A 402
GLU A 383
 None
 0.86A 3c6gA-4cokA:
undetectable		 3c6gA-4cokA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 10 ILE A  97
ILE A 166
VAL A 170
GLY A 172
TYR A   3
 None
 1.02A 3elzC-4cokA:
undetectable		 3elzC-4cokA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 6 LEU A 396
GLU A 252
PRO A 251
HIS A 260
 None
 1.21A 3ltwA-4cokA:
undetectable		 3ltwA-4cokA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		3 / 3 GLN A 351
THR A 352
LEU A 374
 None
 0.67A 3ondA-4cokA:
3.5		 3ondA-4cokA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		3 / 3 GLN A 351
THR A 352
LEU A 374
 None
 0.65A 3ondB-4cokA:
undetectable		 3ondB-4cokA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 GLY A  54
PRO A 416
ASN A  49
ALA A 417
PHE A  81
 None
 0.96A 3p2kC-4cokA:
undetectable		 3p2kC-4cokA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 6 VAL A 304
LEU A 306
ILE A 281
CYH A 282
 None
 0.91A 4asdA-4cokA:
undetectable		 4asdA-4cokA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 7 ALA A 183
ALA A  66
GLY A  65
GLY A  17
 None
 0.58A 4eatA-4cokA:
4.8		 4eatA-4cokA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 ASN A  29
GLN A 124
ALA A  77
SER A  74
TYR A 123
 None
 1.29A 4ejwA-4cokA:
undetectable		 4ejwA-4cokA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 PRO A 426
TYR A  60
GLY A 420
ASN A 421
ILE A  45
 None
 1.28A 4kosA-4cokA:
undetectable		 4kosA-4cokA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 PRO A 426
TYR A  60
GLY A 420
ASN A 421
ILE A  45
 None
 1.29A 4kotA-4cokA:
undetectable		 4kotA-4cokA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 PRO A 426
TYR A  60
GLY A 420
ASN A 421
ILE A  45
 None
 1.34A 4kovA-4cokA:
undetectable		 4kovA-4cokA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 11 PRO A 426
TYR A  60
GLY A 420
ASN A 421
ILE A  45
 None
 1.30A 4koyA-4cokA:
undetectable		 4koyA-4cokA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 ARG A 309
ALA A 155
LEU A 156
LEU A  18
ILE A  95
 None
 1.15A 4lnwA-4cokA:
undetectable		 4lnwA-4cokA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 ARG A 309
ALA A 155
LEU A 156
LEU A  18
ILE A  95
 None
 1.16A 4lnxA-4cokA:
undetectable		 4lnxA-4cokA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 ALA A 367
MET A 433
LEU A 374
ILE A 457
ILE A 514
 None
 1.16A 4ptjA-4cokA:
undetectable		 4ptjA-4cokA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 7 CYH A 529
LEU A 510
GLY A 508
GLY A 507
 None
 0.81A 5a06B-4cokA:
2.3		 5a06B-4cokA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 6 CYH A 529
GLU A 509
GLY A 508
GLY A 507
 None
 1.01A 5a06D-4cokA:
3.6		 5a06D-4cokA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 5 ASP A 386
TRP A 388
VAL A 392
ALA A 391
 None
 1.35A 5dl9A-4cokA:
undetectable		 5dl9A-4cokA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 LEU A 460
LEU A 488
MET A 449
ILE A 450
GLY A 499
 None
 0.96A 5gtrA-4cokA:
undetectable		 5gtrA-4cokA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 LEU A 328
ARG A 219
ILE A 220
GLY A 217
MET A 243
 None
 0.90A 5ifuA-4cokA:
2.4		 5ifuA-4cokA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 5 TYR A 347
GLY A 259
THR A 241
GLY A 435
 None
None
None
TPP  A 600 (-3.4A)
 0.84A 5jlcA-4cokA:
undetectable		 5jlcA-4cokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		4 / 5 SER A  98
VAL A  71
GLY A  76
ALA A  77
 None
 0.94A 5k50A-4cokA:
undetectable		 5k50A-4cokA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 9 ALA A  69
ILE A  16
LEU A  13
ILE A 152
ALA A  57
 None
 0.95A 5nunA-4cokA:
undetectable		 5nunA-4cokA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 GLY A 435
ILE A 461
MET A 471
TYR A 466
VAL A 480
 TPP  A 600 (-3.4A)
TPP  A 600 ( 4.7A)
None
TPP  A 600 (-3.6A)
None
 1.05A 5nz0A-4cokA:
undetectable		 5nz0A-4cokA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4cok PYRUVATE
DECARBOXYLASE
(Gluconacetobacte
r
diazotrophicus) 		5 / 12 LEU A  18
ILE A  97
ALA A 183
ASP A 182
LEU A 156
 None
 1.14A 6ie8A-4cokA:
undetectable		 6ie8A-4cokA:
15.78