SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4con'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 7 TYR A 227
ILE A 555
TYR A 584
GLY A 361
 None
 0.94A 11gsA-4conA:
undetectable		 11gsA-4conA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 7 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 0.99A 1dvxA-4conA:
undetectable		 1dvxA-4conA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 7 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 1.00A 1dvxB-4conA:
undetectable		 1dvxB-4conA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 PHE A 490
ILE A 438
LYS A 403
ALA A 406
 None
 1.19A 1hk2A-4conA:
undetectable		 1hk2A-4conA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 130
VAL A 134
LEU A 152
HIS A 208
ILE A 211
 None
 1.10A 1s9pA-4conA:
undetectable		 1s9pA-4conA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 130
VAL A 134
LEU A 152
HIS A 208
ILE A 211
 None
 1.09A 1s9pD-4conA:
undetectable		 1s9pD-4conA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 0.90A 1tz8C-4conA:
undetectable
1tz8D-4conA:
undetectable		 1tz8C-4conA:
11.55
1tz8D-4conA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 4 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 1.08A 1tz8D-4conA:
undetectable		 1tz8D-4conA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 9 ASP A  30
TYR A  79
LEU A  18
LEU A  14
TYR A  22
 None
 1.30A 2bfmA-4conA:
3.3
2bfmD-4conA:
3.2		 2bfmA-4conA:
17.68
2bfmD-4conA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 TYR A 227
ILE A 555
TYR A 584
GLY A 361
 None
 0.91A 2gssA-4conA:
2.3		 2gssA-4conA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 TYR A 227
ILE A 555
TYR A 584
GLY A 361
 None
 0.90A 2gssB-4conA:
undetectable		 2gssB-4conA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 7 TYR A 227
GLU A 495
TYR A 584
GLY A 553
 None
 1.15A 2ha4B-4conA:
2.4		 2ha4B-4conA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 LEU A 212
PRO A 226
SER A 225
VAL A 174
 None
 1.06A 2qd2A-4conA:
undetectable		 2qd2A-4conA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 5 PHE A 180
PHE A 280
SER A 225
PHE A 209
 None
 1.29A 2v0mD-4conA:
undetectable		 2v0mD-4conA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 SER A 320
THR A 286
LEU A 285
ASP A 314
ILE A 305
 None
 1.13A 2wa2A-4conA:
undetectable		 2wa2A-4conA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 11 PRO A 377
ARG A 378
VAL A 440
GLN A 496
GLY A 552
 None
 1.18A 3bf6H-4conA:
undetectable		 3bf6H-4conA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 4 THR A 453
VAL A 470
GLY A 442
THR A 441
 None
 0.91A 3cflA-4conA:
undetectable		 3cflA-4conA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 1.00A 3cfqA-4conA:
undetectable		 3cfqA-4conA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 TYR A 112
ASP A  30
HIS A 117
 CIT  A1589 (-4.6A)
None
CIT  A1589 (-4.3A)
 0.92A 3e23A-4conA:
undetectable		 3e23A-4conA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 10 TYR A 227
VAL A 284
GLY A 360
ILE A 555
ASN A 316
 None
 1.30A 3km6A-4conA:
undetectable		 3km6A-4conA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 ILE A 133
SER A 146
GLY A 137
ASN A 426
 None
 0.94A 3lslA-4conA:
undetectable
3lslD-4conA:
undetectable		 3lslA-4conA:
15.87
3lslD-4conA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 ILE A 133
VAL A 134
ILE A 205
TYR A 204
LEU A 152
 None
 1.04A 3mb5A-4conA:
undetectable		 3mb5A-4conA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 TYR A 227
ILE A 555
TYR A 584
GLY A 361
 None
 0.94A 3n9jA-4conA:
undetectable		 3n9jA-4conA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 PHE A 179
MET A 183
PRO A 283
ILE A 160
VAL A 163
 None
 1.13A 3p6gA-4conA:
undetectable		 3p6gA-4conA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 GLY A 439
VAL A 371
HIS A 114
THR A 437
 None
None
CIT  A1589 (-4.0A)
None
 1.11A 3tj7A-4conA:
undetectable
3tj7B-4conA:
undetectable		 3tj7A-4conA:
15.11
3tj7B-4conA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 GLY A 439
VAL A 371
HIS A 114
THR A 437
 None
None
CIT  A1589 (-4.0A)
None
 1.09A 3tj7C-4conA:
undetectable
3tj7D-4conA:
undetectable		 3tj7C-4conA:
15.11
3tj7D-4conA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 VAL A 371
HIS A 114
THR A 437
GLY A 439
 None
CIT  A1589 (-4.0A)
None
None
 1.06A 3tj7C-4conA:
undetectable
3tj7D-4conA:
undetectable		 3tj7C-4conA:
15.11
3tj7D-4conA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 GLY A 436
TYR A 485
ALA A 481
GLU A 482
 None
 0.81A 4bjcA-4conA:
undetectable		 4bjcA-4conA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 GLN A 313
ASN A 306
ASN A 316
THR A 286
 None
 1.18A 4d1yA-4conA:
undetectable
4d1yB-4conA:
undetectable		 4d1yA-4conA:
14.66
4d1yB-4conA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 GLU A 299
PHE A 571
ASP A 298
ASP A 234
ASN A 236
 None
 1.46A 4djfB-4conA:
undetectable		 4djfB-4conA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 TYR A 462
LEU A 474
VAL A 440
VAL A 443
 None
 0.98A 4em2A-4conA:
1.9		 4em2A-4conA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 5 ALA A 481
ILE A 401
LEU A 405
LYS A 402
 None
 1.04A 4g19A-4conA:
undetectable		 4g19A-4conA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 0.87A 4i89A-4conA:
undetectable		 4i89A-4conA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A 443
LEU A 376
ILE A 477
VAL A 550
LEU A 474
 None
 0.90A 4o1zB-4conA:
1.0		 4o1zB-4conA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 THR A 534
ASN A 588
PHE A 587
 None
 0.77A 4pd9A-4conA:
undetectable		 4pd9A-4conA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U3E_A_ACTA705_0
(RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 4 HIS A 114
ASP A 115
TYR A 124
VAL A 371
 CIT  A1589 (-4.0A)
CIT  A1589 (-3.8A)
None
None
 0.18A 4u3eA-4conA:
52.6		 4u3eA-4conA:
97.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  83
VAL A 408
LYS A 403
ALA A 407
ILE A 372
 None
 0.96A 4x1kD-4conA:
undetectable		 4x1kD-4conA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  83
VAL A 408
LYS A 403
ALA A 407
ILE A 372
 None
 0.97A 4x1yD-4conA:
3.1		 4x1yD-4conA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  83
VAL A 408
LYS A 403
ALA A 407
ILE A 372
 None
 0.99A 4x20B-4conA:
undetectable		 4x20B-4conA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 ARG A 275
ASP A 314
TRP A 312
 None
 0.94A 4xdqA-4conA:
undetectable		 4xdqA-4conA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 4 LEU A 381
ARG A 397
ILE A 379
ILE A 393
 None
 1.03A 5dzk2-4conA:
undetectable
5dzkM-4conA:
2.1
5dzkN-4conA:
2.1		 5dzk2-4conA:
10.53
5dzkM-4conA:
15.11
5dzkN-4conA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 4 ILE A 379
ILE A 393
ARG A 397
LEU A 381
 None
 1.27A 5dzkh-4conA:
2.1
5dzkn-4conA:
2.1
5dzkv-4conA:
undetectable		 5dzkh-4conA:
15.11
5dzkn-4conA:
15.11
5dzkv-4conA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 ASP A 363
SER A 288
TYR A 318
 None
 0.87A 5glmA-4conA:
undetectable		 5glmA-4conA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 6 LYS A 295
LEU A 297
LEU A 290
SER A 320
 None
 1.12A 5l4iB-4conA:
undetectable		 5l4iB-4conA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 TYR A 124
MET A 356
GLY A 439
VAL A 550
VAL A 497
 None
 1.14A 5ubbA-4conA:
undetectable		 5ubbA-4conA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 HIS A 114
VAL A 497
LEU A 376
LEU A 506
ALA A 502
 CIT  A1589 (-4.0A)
None
None
None
CIT  A1589 (-3.5A)
 1.18A 5xprA-4conA:
1.8		 5xprA-4conA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 10 GLY A 484
ALA A 406
LEU A 405
GLY A 436
LEU A  32
 None
 1.32A 6hqbA-4conA:
undetectable
6hqbJ-4conA:
undetectable		 6hqbA-4conA:
7.04
6hqbJ-4conA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 10 TRP A 527
MET A 356
SER A 362
GLY A 360
LEU A 391
 None
 1.38A 6hqbA-4conA:
undetectable
6hqbJ-4conA:
undetectable		 6hqbA-4conA:
7.04
6hqbJ-4conA:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 11 ASP A 249
SER A 251
VAL A 134
ALA A 127
VAL A 181
 None
 1.37A 6hu9A-4conA:
undetectable
6hu9E-4conA:
undetectable
6hu9I-4conA:
undetectable		 6hu9A-4conA:
22.19
6hu9E-4conA:
14.11
6hu9I-4conA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 10 ASP A 249
SER A 251
TYR A 185
VAL A 134
ALA A 127
 None
 1.47A 6hu9L-4conA:
undetectable
6hu9P-4conA:
undetectable
6hu9T-4conA:
undetectable		 6hu9L-4conA:
22.19
6hu9P-4conA:
14.11
6hu9T-4conA:
8.46