SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
3 / 3 ALA A 127
VAL A 170
TRP A 100
None
TRS  A1471 (-3.9A)
TRS  A1471 (-3.5A)
0.85A 1av2C-4cotA:
undetectable
1av2D-4cotA:
undetectable
1av2C-4cotA:
6.78
1av2D-4cotA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
5 / 12 GLY A 192
ASN A 168
GLY A 210
VAL A 185
LEU A 196
None
0.90A 1jg4A-4cotA:
undetectable
1jg4A-4cotA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
5 / 11 LEU A 215
TYR A 266
GLY A 187
GLY A 192
TYR A 227
None
1.15A 1p91A-4cotA:
undetectable
1p91A-4cotA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
3 / 3 ALA A 127
VAL A 170
TRP A 100
None
TRS  A1471 (-3.9A)
TRS  A1471 (-3.5A)
0.79A 1w5uC-4cotA:
undetectable
1w5uD-4cotA:
undetectable
1w5uC-4cotA:
6.78
1w5uD-4cotA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 6 PHE A 303
ARG A 448
GLY A 467
THR A 454
None
1.03A 2f7fA-4cotA:
undetectable
2f7fA-4cotA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
3 / 3 TRP A 100
ALA A 127
VAL A 170
TRS  A1471 (-3.5A)
None
TRS  A1471 (-3.9A)
0.67A 2izqA-4cotA:
undetectable
2izqB-4cotA:
undetectable
2izqA-4cotA:
6.78
2izqB-4cotA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 6 TYR A 365
TRP A 466
TYR A 301
ILE A 387
None
1.38A 2pgzD-4cotA:
undetectable
2pgzE-4cotA:
undetectable
2pgzD-4cotA:
18.97
2pgzE-4cotA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
5 / 12 LEU A 246
HIS A 335
GLU A 224
ASP A 171
GLY A  52
TRS  A1471 (-3.8A)
None
TRS  A1471 (-2.1A)
TRS  A1471 (-2.7A)
None
1.41A 3ce6A-4cotA:
undetectable
3ce6A-4cotA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
5 / 12 LEU A 246
HIS A 335
GLU A 224
ASP A 171
GLY A  52
TRS  A1471 (-3.8A)
None
TRS  A1471 (-2.1A)
TRS  A1471 (-2.7A)
None
1.42A 3ce6C-4cotA:
undetectable
3ce6C-4cotA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 6 LYS A 385
SER A 456
THR A 454
VAL A 452
None
0.97A 3d2tB-4cotA:
undetectable
3d2tB-4cotA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
3 / 3 ALA A 127
VAL A 170
TRP A 100
None
TRS  A1471 (-3.9A)
TRS  A1471 (-3.5A)
0.66A 3l8lA-4cotA:
undetectable
3l8lB-4cotA:
undetectable
3l8lA-4cotA:
6.78
3l8lB-4cotA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
3 / 3 ALA A 127
VAL A 170
TRP A 100
None
TRS  A1471 (-3.9A)
TRS  A1471 (-3.5A)
0.77A 3l8lC-4cotA:
undetectable
3l8lD-4cotA:
undetectable
3l8lC-4cotA:
6.78
3l8lD-4cotA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 6 TYR A 252
GLY A 317
HIS A  37
THR A 336
None
None
TRS  A1471 (-4.4A)
None
0.95A 3tj7A-4cotA:
undetectable
3tj7B-4cotA:
undetectable
3tj7A-4cotA:
18.98
3tj7B-4cotA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 6 TYR A 252
GLY A 317
HIS A  37
THR A 336
None
None
TRS  A1471 (-4.4A)
None
0.95A 3tj7C-4cotA:
undetectable
3tj7D-4cotA:
undetectable
3tj7C-4cotA:
18.98
3tj7D-4cotA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 6 HIS A  37
THR A 336
TYR A 252
GLY A 317
TRS  A1471 (-4.4A)
None
None
None
0.97A 3tj7C-4cotA:
undetectable
3tj7D-4cotA:
undetectable
3tj7C-4cotA:
18.98
3tj7D-4cotA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 7 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.16A 4fevB-4cotA:
undetectable
4fevB-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 7 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.09A 4fevD-4cotA:
undetectable
4fevD-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 7 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.09A 4fevF-4cotA:
undetectable
4fevF-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 8 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.09A 4fewD-4cotA:
undetectable
4fewD-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 8 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.11A 4fewF-4cotA:
undetectable
4fewF-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 7 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.12A 4fexB-4cotA:
undetectable
4fexB-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 8 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.11A 4gkhB-4cotA:
undetectable
4gkhB-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 8 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.09A 4gkhF-4cotA:
undetectable
4gkhF-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 7 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.09A 4gkhG-4cotA:
undetectable
4gkhG-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 6 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.13A 4gkhJ-4cotA:
undetectable
4gkhJ-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 8 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.10A 4gkhC-4cotA:
undetectable
4gkhK-4cotA:
undetectable
4gkhC-4cotA:
18.38
4gkhK-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 8 ASP A 287
ASP A 396
ASN A 253
ASP A 392
None
1.10A 4gkiC-4cotA:
undetectable
4gkiC-4cotA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
5 / 11 ASP A 109
VAL A 130
ALA A 131
TYR A 115
TYR A 113
None
1.28A 4mm9A-4cotA:
undetectable
4mm9A-4cotA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 7 GLU A 224
ARG A 337
GLY A 245
HIS A  37
TRS  A1471 (-2.1A)
None
None
TRS  A1471 (-4.4A)
1.01A 4qwpB-4cotA:
undetectable
4qwpB-4cotA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 4 TYR A 313
THR A 336
GLY A 317
LEU A 332
None
0.96A 4w5nA-4cotA:
undetectable
4w5nA-4cotA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 5 GLY A 245
SER A 315
GLU A 224
ASP A 247
None
None
TRS  A1471 (-2.1A)
None
1.34A 4xueA-4cotA:
undetectable
4xueA-4cotA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 5 TYR A 240
SER A 330
LEU A 229
MET A 354
None
1.24A 4yo9A-4cotA:
undetectable
4yo9B-4cotA:
undetectable
4yo9A-4cotA:
20.62
4yo9B-4cotA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 5 LEU A  99
TYR A 116
MET A 128
CYH A 119
None
1.31A 5p9iA-4cotA:
undetectable
5p9iA-4cotA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
4 / 7 GLY A 217
GLN A 318
TYR A 252
TYR A 186
None
NI  A1470 ( 2.6A)
None
None
1.05A 5vlmG-4cotA:
undetectable
5vlmG-4cotA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
5 / 12 MET A 114
VAL A 104
PHE A  51
GLU A 137
THR A  70
None
1.41A 5w8aA-4cotA:
undetectable
5w8aA-4cotA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
3 / 3 TYR A 237
ASP A 263
ASP A 177
None
0.79A 5x6yA-4cotA:
undetectable
5x6yA-4cotA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis)
3 / 3 TYR A 243
ALA A 257
LEU A 216
None
0.76A 6d9kF-4cotA:
undetectable
6d9kF-4cotA:
20.72