SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		4 / 8 PHE A 267
LEU A 238
ALA A 226
PHE A 201
 None
 0.62A 1epbB-4cp2A:
undetectable		 1epbB-4cp2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		4 / 7 PHE A 170
PHE A 173
MET A 175
VAL A 176
 None
 1.01A 1wrlA-4cp2A:
undetectable
1wrlB-4cp2A:
undetectable		 1wrlA-4cp2A:
15.17
1wrlB-4cp2A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		5 / 12 LEU A 238
VAL A 240
LEU A 242
ILE A 250
ALA A 208
 None
 1.16A 2gj5A-4cp2A:
undetectable		 2gj5A-4cp2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		4 / 8 ILE A 250
PHE A 191
TYR A 284
LEU A 242
 None
 0.82A 2w98B-4cp2A:
undetectable		 2w98B-4cp2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		4 / 4 PHE A 253
TYR A 227
ILE A 140
LEU A  63
 None
 1.43A 3sudA-4cp2A:
undetectable		 3sudA-4cp2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		4 / 7 SER A 171
PHE A 147
ASN A 172
ASP A 258
 None
None
None
GAL  A1296 ( 3.5A)
 1.32A 4kcnB-4cp2A:
undetectable		 4kcnB-4cp2A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		3 / 3 GLU A 210
LYS A 206
ASN A 220
 None
 1.06A 4y1dA-4cp2A:
undetectable
4y1dD-4cp2A:
undetectable		 4y1dA-4cp2A:
20.69
4y1dD-4cp2A:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		5 / 12 LEU A 238
PHE A 191
LEU A 283
PHE A 201
ALA A 208
 None
 1.37A 5ieoA-4cp2A:
undetectable		 5ieoA-4cp2A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		5 / 12 TYR A 162
PHE A 173
ILE A 168
LEU A  67
LEU A 177
 None
 1.40A 5zwrB-4cp2A:
undetectable		 5zwrB-4cp2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4cp2 EPITHELIAL ADHESIN 9
([Candida]
glabrata) 		4 / 8 SER A 171
PHE A 147
ASN A 172
ASP A 258
 None
None
None
GAL  A1296 ( 3.5A)
 1.26A 6auuB-4cp2A:
undetectable		 6auuB-4cp2A:
19.15