SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cp6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 7 THR A  38
THR A  90
GLY A  92
ASP A  93
 None
 0.86A 1bu5A-4cp6A:
undetectable		 1bu5A-4cp6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 8 THR A  38
THR A  90
GLY A  92
ASP A  93
 None
 0.82A 1bu5B-4cp6A:
2.0		 1bu5B-4cp6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 ILE A 374
LEU A 427
PHE A 408
LEU A 382
LEU A 368
 None
 1.01A 1dtlA-4cp6A:
undetectable		 1dtlA-4cp6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 6 ALA A 335
LEU A 342
LEU A 324
LEU A 368
 None
 0.98A 1mt1D-4cp6A:
undetectable
1mt1E-4cp6A:
undetectable		 1mt1D-4cp6A:
11.09
1mt1E-4cp6A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		6 / 12 ILE A 394
ILE A 392
ASN A 435
LEU A 427
ASN A 430
VAL A 414
 None
 1.45A 2nnhA-4cp6A:
undetectable		 2nnhA-4cp6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 7 LEU A 324
ILE A 322
ASN A 339
PHE A 313
 None
 0.91A 2opxA-4cp6A:
undetectable		 2opxA-4cp6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 264
PHE A 257
LEU A 285
LEU A 324
PRO A 325
 None
 1.21A 2qd4A-4cp6A:
undetectable		 2qd4A-4cp6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 11 LEU A 319
ILE A 322
ALA A 335
PHE A 336
LEU A 324
 None
 1.16A 2qjuA-4cp6A:
undetectable		 2qjuA-4cp6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 386
ILE A 392
ILE A 410
ILE A 374
VAL A 358
 None
 0.98A 2ygoA-4cp6A:
undetectable		 2ygoA-4cp6A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 5 VAL A  53
VAL A  40
THR A  99
THR A  38
 None
 1.04A 3bjwA-4cp6A:
undetectable		 3bjwA-4cp6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 5 VAL A  53
VAL A  40
THR A  99
THR A  38
 None
 1.09A 3bjwG-4cp6A:
undetectable		 3bjwG-4cp6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 5 VAL A  53
VAL A  40
THR A  99
THR A  38
 None
 1.10A 3bjwC-4cp6A:
undetectable		 3bjwC-4cp6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 5 VAL A  53
VAL A  40
THR A  99
THR A  38
 None
 1.04A 3bjwD-4cp6A:
undetectable		 3bjwD-4cp6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 ASP A 162
VAL A 101
ILE A 129
ILE A 169
ALA A 182
 None
 1.19A 3ohtA-4cp6A:
undetectable
3ohtB-4cp6A:
undetectable		 3ohtA-4cp6A:
21.29
3ohtB-4cp6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 6 PHE A 313
LEU A 324
THR A 282
LEU A 299
 None
 1.00A 3t3zA-4cp6A:
undetectable		 3t3zA-4cp6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 6 PHE A 313
LEU A 324
THR A 282
LEU A 299
 None
 0.99A 3t3zB-4cp6A:
undetectable		 3t3zB-4cp6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 6 PHE A 313
LEU A 324
THR A 282
LEU A 299
 None
 1.01A 3t3zD-4cp6A:
undetectable		 3t3zD-4cp6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 6 PHE A 185
LEU A 233
GLU A 206
SER A 184
 None
 1.19A 3vlnA-4cp6A:
undetectable		 3vlnA-4cp6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 342
LEU A 365
LEU A 386
ILE A 322
VAL A 358
 None
 1.10A 4f4dA-4cp6A:
undetectable		 4f4dA-4cp6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 342
LEU A 365
LEU A 386
ILE A 322
VAL A 358
 None
 1.23A 4f4dB-4cp6A:
undetectable		 4f4dB-4cp6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 TYR A 337
GLY A 338
ASN A 339
ARG A 232
LEU A 233
 None
 0.96A 4kotA-4cp6A:
undetectable		 4kotA-4cp6A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 TYR A 337
GLY A 338
ASN A 339
ARG A 232
LEU A 233
 None
 1.06A 4kovA-4cp6A:
undetectable		 4kovA-4cp6A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOX_A_CLSA205_1
(UNCHARACTERIZED
PROTEIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 11 TYR A 337
GLY A 338
ASN A 339
ARG A 232
LEU A 233
 None
 0.95A 4koxA-4cp6A:
undetectable		 4koxA-4cp6A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 11 TYR A 337
GLY A 338
ASN A 339
ARG A 232
LEU A 233
 None
 1.02A 4koyA-4cp6A:
undetectable		 4koyA-4cp6A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 5 THR A 282
PRO A 279
PHE A 290
TYR A 276
 None
 1.21A 4mf6A-4cp6A:
undetectable		 4mf6A-4cp6A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 PHE A 231
ILE A 265
LEU A 226
LEU A 192
LEU A 217
 None
 1.35A 4qynB-4cp6A:
undetectable		 4qynB-4cp6A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 ALA A 335
VAL A 255
LEU A 285
LEU A 296
LEU A 299
 None
 1.13A 4qzuC-4cp6A:
undetectable		 4qzuC-4cp6A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 7 ILE A 331
PHE A 354
THR A 369
LEU A 368
 None
 0.82A 5b1bN-4cp6A:
undetectable
5b1bW-4cp6A:
undetectable		 5b1bN-4cp6A:
20.91
5b1bW-4cp6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 7 ILE A 331
PHE A 354
THR A 369
LEU A 368
 None
 0.86A 5b3sN-4cp6A:
undetectable
5b3sW-4cp6A:
undetectable		 5b3sN-4cp6A:
20.91
5b3sW-4cp6A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 PHE A 408
VAL A 418
GLY A 371
LEU A 368
THR A 369
 None
 1.14A 5byjA-4cp6A:
undetectable		 5byjA-4cp6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 VAL A 418
GLY A 371
PHE A 401
LEU A 368
THR A 369
 None
 1.02A 5byjA-4cp6A:
undetectable		 5byjA-4cp6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 VAL A 101
PRO A 172
ILE A 203
SER A 174
LEU A 192
 None
 1.11A 5hbsA-4cp6A:
undetectable		 5hbsA-4cp6A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 7 ILE A 331
PHE A 354
THR A 369
LEU A 368
 None
 0.84A 5iy5N-4cp6A:
undetectable
5iy5W-4cp6A:
undetectable		 5iy5N-4cp6A:
20.91
5iy5W-4cp6A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 6 LEU A 427
PHE A 416
ASP A 436
HIS A 393
 None
 1.11A 5om3A-4cp6A:
undetectable
5om3B-4cp6A:
undetectable		 5om3A-4cp6A:
10.85
5om3B-4cp6A:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 8 ILE A 322
ASN A 293
PRO A 279
THR A 278
 None
 0.98A 5x23A-4cp6A:
undetectable		 5x23A-4cp6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 9 LEU A 345
GLY A 371
ILE A 370
PHE A 336
ILE A 331
 None
 1.18A 6ebpA-4cp6A:
undetectable		 6ebpA-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 10 LEU A 345
GLY A 371
ILE A 370
PHE A 336
ILE A 331
 None
 1.19A 6ebpB-4cp6A:
undetectable		 6ebpB-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 10 LEU A 345
GLY A 371
ILE A 370
PHE A 336
ILE A 331
 None
 1.15A 6ebpC-4cp6A:
undetectable		 6ebpC-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 10 PHE A 161
SER A 140
GLY A 139
ILE A 145
ILE A 123
 None
 1.11A 6ebpD-4cp6A:
undetectable		 6ebpD-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 11 LEU A 345
GLY A 371
ILE A 374
PHE A 336
ILE A 331
 None
 1.01A 6ebzA-4cp6A:
undetectable		 6ebzA-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 11 LEU A 345
GLY A 371
ILE A 374
PHE A 336
ILE A 331
 None
 1.03A 6ebzB-4cp6A:
undetectable		 6ebzB-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 11 LEU A 345
GLY A 371
ILE A 374
PHE A 336
ILE A 331
 None
 0.98A 6ebzC-4cp6A:
undetectable		 6ebzC-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 11 LEU A 345
GLY A 371
ILE A 374
PHE A 336
ILE A 331
 None
 1.04A 6ebzD-4cp6A:
undetectable		 6ebzD-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 7 LEU A 342
PHE A 381
GLY A 371
LEU A 324
 None
 0.79A 6eu9D-4cp6A:
undetectable		 6eu9D-4cp6A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 175
LEU A 153
ALA A 207
LEU A 200
LEU A 217
 None
 1.01A 6ew0B-4cp6A:
undetectable		 6ew0B-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 175
LEU A 153
ALA A 207
LEU A 200
LEU A 217
 None
 1.01A 6ew0D-4cp6A:
undetectable		 6ew0D-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 GLU A 157
LEU A 217
ALA A 182
LEU A 192
LEU A 175
 None
 1.25A 6ew0F-4cp6A:
undetectable		 6ew0F-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 217
ALA A 182
PHE A 183
LEU A 192
LEU A 175
 None
 1.07A 6ew0G-4cp6A:
undetectable		 6ew0G-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 175
LEU A 153
ALA A 207
LEU A 200
LEU A 217
 None
 1.01A 6ew0H-4cp6A:
undetectable		 6ew0H-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 175
LEU A 153
ALA A 207
LEU A 200
LEU A 217
 None
 1.01A 6ew0I-4cp6A:
undetectable		 6ew0I-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4cp6 CHOLINE BINDING
PROTEIN PCPA
(Streptococcus
pneumoniae) 		4 / 7 ILE A 346
LEU A 324
VAL A 358
LEU A 368
 None
 0.72A 6g9bA-4cp6A:
undetectable
6g9bB-4cp6A:
undetectable		 6g9bA-4cp6A:
13.51
6g9bB-4cp6A:
11.03