SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
5 / 12 TYR B 148
ILE B  14
GLY B 134
SER B 151
GLY B 179
None
NAP  B 301 (-3.7A)
None
None
None
1.11A 1kiaA-4cqmB:
8.1
1kiaA-4cqmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
3 / 3 ALA B 210
HIS B 211
VAL B 214
None
0.50A 1lqtB-4cqmB:
5.6
1lqtB-4cqmB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
3 / 3 ALA B 210
HIS B 211
VAL B 214
None
0.51A 1lquB-4cqmB:
5.1
1lquB-4cqmB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
5 / 12 TYR B 148
ILE B  14
GLY B 134
SER B 151
GLY B 179
None
NAP  B 301 (-3.7A)
None
None
None
1.13A 1nbiA-4cqmB:
7.6
1nbiA-4cqmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
5 / 12 TYR B 148
ILE B  14
GLY B 134
SER B 151
GLY B 179
None
NAP  B 301 (-3.7A)
None
None
None
1.13A 1nbiB-4cqmB:
7.7
1nbiB-4cqmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
4 / 5 LEU B 113
GLY B 110
PHE B  67
ASN B 132
None
1.17A 3uq6B-4cqmB:
6.2
3uq6B-4cqmB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
6 / 12 GLY B 138
SER B 149
ASN B 142
ILE B 136
ALA B 177
VAL B 228
None
1.15A 4dx5B-4cqmB:
undetectable
4dx5B-4cqmB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
4 / 8 ALA B  19
THR B 114
VAL B  63
PHE B  67
None
1.00A 4ltwA-4cqmB:
undetectable
4ltwA-4cqmB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
4 / 8 PRO B 178
VAL B 209
VAL B 137
GLY B 138
NAP  B 301 (-4.5A)
None
None
None
0.72A 4mk4A-4cqmB:
3.8
4mk4A-4cqmB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
6 / 12 GLY B 138
SER B 149
ASN B 142
ILE B 136
ALA B 177
VAL B 228
None
1.13A 4u8yB-4cqmB:
undetectable
4u8yB-4cqmB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
6 / 12 GLY B 138
SER B 149
ASN B 142
ILE B 136
ALA B 177
VAL B 228
None
1.13A 4u95B-4cqmB:
undetectable
4u95B-4cqmB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
4 / 7 VAL B 226
ALA B 177
GLY B 138
ARG B 160
None
0.81A 5fpdA-4cqmB:
undetectable
5fpdA-4cqmB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4

(Homo
sapiens)
5 / 12 GLY B  85
VAL B 133
GLN B 145
VAL B 209
GLY B  15
NAP  B 301 (-3.4A)
None
None
None
None
1.17A 6gneA-4cqmB:
4.6
6gneA-4cqmB:
20.73