SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 GLY I 258
LEU I 257
GLY I 260
ARG I 304
 None
 1.00A 1j7kA-4cr2I:
14.1		 1j7kA-4cr2I:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 8 ILE I 302
GLU I 299
ILE I 284
LEU I 252
 None
 0.81A 4mj8A-4cr2I:
undetectable		 4mj8A-4cr2I:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 SER I 367
GLY I 363
GLY I 185
GLU I 179
TYR I 181
 None
 0.85A 4r29C-4cr2I:
undetectable		 4r29C-4cr2I:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ALA I 242
THR I 240
LEU I 202
LYS I 323
ALA I 275
 None
 1.22A 4ypmA-4cr2I:
2.9		 4ypmA-4cr2I:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 VAL I 120
ALA I 118
VAL I 130
TYR I 129
 None
 0.77A 5i8fA-4cr2I:
undetectable		 5i8fA-4cr2I:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 SER I 277
VAL I 322
GLY I 272
ALA I 271
 None
 0.89A 5k50A-4cr2I:
undetectable		 5k50A-4cr2I:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY I 226
HIS I 365
GLU I 283
THR I 230
PHE I 280
 None
 1.21A 5x6yA-4cr2I:
undetectable		 5x6yA-4cr2I:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 LYS I 214
LEU I 202
ASP I 321
 None
 0.85A 5zv2A-4cr2I:
undetectable		 5zv2A-4cr2I:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU I 109
GLY I 107
ILE I 106
VAL I 136
ILE I 156
 None
 0.97A 6emuA-4cr2I:
undetectable		 6emuA-4cr2I:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU I 109
GLY I 107
ILE I 106
VAL I 136
ILE I 156
 None
 0.94A 6emuB-4cr2I:
undetectable		 6emuB-4cr2I:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU I 109
GLY I 107
ILE I 106
VAL I 136
ILE I 156
 None
 0.98A 6emuC-4cr2I:
undetectable		 6emuC-4cr2I:
19.62