SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 LEU K 371
GLU K 408
ALA K 366
LEU K 368
 None
 1.20A 1eta1-4cr4K:
undetectable		 1eta1-4cr4K:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 LEU K 371
GLU K 408
ALA K 366
LEU K 368
 None
 1.16A 1eta2-4cr4K:
undetectable		 1eta2-4cr4K:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU K 371
GLU K 408
ALA K 366
LEU K 368
 None
 1.19A 1etb1-4cr4K:
undetectable		 1etb1-4cr4K:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU K 371
GLU K 408
ALA K 366
LEU K 368
 None
 1.17A 1etb2-4cr4K:
undetectable		 1etb2-4cr4K:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 MET L 312
LEU L 337
LEU L 343
ILE L 286
VAL L 196
 None
 1.27A 1hrkB-4cr4L:
2.1		 1hrkB-4cr4L:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		4 / 7 VAL L 380
SER L 383
ASP L 390
LYS L 426
 None
 1.36A 1hwiD-4cr4L:
undetectable		 1hwiD-4cr4L:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 PHE J 246
LEU K 300
ARG K 330
GLY J 254
ILE J 253
 None
 1.21A 1kglA-4cr4J:
undetectable		 1kglA-4cr4J:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ASP K 256
ASP K 155
ILE K 235
ASP K 272
ILE K 269
 None
 1.43A 1kijA-4cr4K:
undetectable		 1kijA-4cr4K:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 LEU H 187
VAL H 174
ALA H  77
CYH H 102
 None
 1.17A 1mz9D-4cr4H:
undetectable		 1mz9D-4cr4H:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU J 300
LEU J 297
THR J 256
ILE J 310
LEU J 304
 None
 1.17A 1tw4B-4cr4J:
undetectable		 1tw4B-4cr4J:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP K 153
ARG L 126
ASP K 256
 None
 0.84A 1vptA-4cr4K:
undetectable		 1vptA-4cr4K:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 LEU L 231
GLY L 182
GLY L 184
GLY L 356
ARG L 357
 None
 1.24A 1y4lA-4cr4L:
undetectable		 1y4lA-4cr4L:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 9 ILE K 297
ASP J 251
GLY J 215
GLU J 249
THR J 256
 None
 1.13A 2dtjA-4cr4K:
undetectable
2dtjB-4cr4K:
undetectable		 2dtjA-4cr4K:
19.30
2dtjB-4cr4K:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 MET L 312
LEU L 337
LEU L 343
ILE L 286
VAL L 196
 None
 1.28A 2pnjB-4cr4L:
undetectable		 2pnjB-4cr4L:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 ARG H 318
THR H 332
VAL H 329
 None
 0.93A 2q64A-4cr4H:
undetectable		 2q64A-4cr4H:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU K 371
GLU K 408
ALA K 366
LEU K 368
 None
 1.11A 2roxB-4cr4K:
undetectable		 2roxB-4cr4K:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 LEU K 299
MET K 303
MET J 247
 None
 0.81A 2vavF-4cr4K:
undetectable		 2vavF-4cr4K:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		4 / 8 LEU L 186
LEU L 230
LYS L 233
ALA L 234
 None
 1.06A 2wekA-4cr4L:
undetectable		 2wekA-4cr4L:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 THR K 279
ARG L 290
LEU K 324
GLU L 293
 None
 1.09A 2zw9A-4cr4K:
undetectable		 2zw9A-4cr4K:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 MET K 316
GLU J 395
ASN J 393
 None
 1.10A 3a27A-4cr4K:
undetectable		 3a27A-4cr4K:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 MET L 312
LEU L 337
LEU L 343
ILE L 286
VAL L 196
 None
 1.33A 3aqiB-4cr4L:
undetectable		 3aqiB-4cr4L:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 VAL J 358
VAL J 361
GLY J 360
PRO K 331
GLY J 192
 None
 1.35A 3bjwG-4cr4J:
undetectable		 3bjwG-4cr4J:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 VAL J 358
VAL J 361
GLY J 360
PRO K 331
GLY J 194
 None
 1.27A 3bjwG-4cr4J:
undetectable		 3bjwG-4cr4J:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 VAL H 263
ALA H 262
VAL H 375
GLU H 219
THR H 267
 None
 1.10A 3dl9A-4cr4H:
undetectable		 3dl9A-4cr4H:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 10 ILE K 269
ILE K 271
VAL K 274
PRO K 215
VAL K 223
 None
 1.15A 3elzC-4cr4K:
undetectable		 3elzC-4cr4K:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 THR J 271
LYS J  87
GLU J 274
 None
 0.89A 3ijdB-4cr4J:
undetectable		 3ijdB-4cr4J:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 246
GLY H 245
ARG H 346
ILE H 371
PRO H 242
 None
 1.06A 3jb1A-4cr4H:
undetectable		 3jb1A-4cr4H:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU H 294
PHE H 295
ILE H 306
CYH H 304
 None
 0.93A 3ko0B-4cr4H:
undetectable		 3ko0B-4cr4H:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 LEU H 294
PHE H 295
ILE H 306
CYH H 304
 None
 0.90A 3ko0S-4cr4H:
undetectable		 3ko0S-4cr4H:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY H 255
PRO H 251
GLY H 212
LEU H 419
ILE H 388
 None
 0.99A 3ku1G-4cr4H:
undetectable		 3ku1G-4cr4H:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY H 255
PRO H 251
GLY H 212
LEU H 419
ILE H 388
 None
 1.03A 3ku1H-4cr4H:
undetectable		 3ku1H-4cr4H:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 11 LEU L 193
VAL L 235
ALA L 236
PHE L 243
PHE L 245
 None
 1.32A 3n23C-4cr4L:
undetectable		 3n23C-4cr4L:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 MET L 312
LEU L 337
LEU L 343
ILE L 286
VAL L 196
 None
 1.30A 3w1wA-4cr4L:
undetectable		 3w1wA-4cr4L:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 MET L 312
LEU L 337
LEU L 343
ILE L 286
VAL L 196
 None
 1.31A 3w1wB-4cr4L:
undetectable		 3w1wB-4cr4L:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		4 / 6 THR L 226
GLY L 388
ILE L 360
LEU L 230
 None
 0.88A 4acbC-4cr4L:
undetectable		 4acbC-4cr4L:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 GLU H 184
ILE H 183
ASN H 182
GLU H 141
 None
 0.95A 4ejwB-4cr4H:
undetectable		 4ejwB-4cr4H:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU J 197
ALA J 293
HIS J 331
ARG K 333
GLY J 360
 None
 1.35A 4l9qA-4cr4J:
2.1		 4l9qA-4cr4J:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 ARG K 333
ASP K 204
GLU J 364
VAL J 377
 None
 1.28A 4nkvB-4cr4K:
undetectable		 4nkvB-4cr4K:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 GLY H 342
ASP H 341
GLU H 335
VAL H 314
 None
 1.08A 4nkvD-4cr4H:
undetectable		 4nkvD-4cr4H:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 ILE K 297
LEU K 296
ASP K 304
GLU K 298
 None
 1.05A 4nkxB-4cr4K:
undetectable		 4nkxB-4cr4K:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 ARG K 333
ASP K 204
GLU J 364
VAL J 377
 None
 1.19A 4nkxC-4cr4K:
undetectable		 4nkxC-4cr4K:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLY K 213
PRO K 214
ALA L 336
 None
 0.40A 4qn9B-4cr4K:
undetectable		 4qn9B-4cr4K:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		4 / 7 VAL K 160
PHE K 242
HIS K 244
GLU L 258
 None
 1.38A 5ad9A-4cr4K:
undetectable
5ad9B-4cr4K:
undetectable		 5ad9A-4cr4K:
21.86
5ad9B-4cr4K:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 PHE H 308
GLY H 276
SER H 277
ILE H 311
ALA H 354
 None
 1.13A 5entC-4cr4H:
undetectable		 5entC-4cr4H:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 GLN J 220
VAL J 213
SER J 214
GLU J 249
LEU J 233
 None
 1.20A 5jh7B-4cr4J:
undetectable		 5jh7B-4cr4J:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 GLN J 220
VAL J 213
SER J 214
GLU J 249
LEU J 233
 None
 1.22A 5jh7D-4cr4J:
undetectable		 5jh7D-4cr4J:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 ALA H 262
GLY H 212
CYH H 214
LYS H 215
 None
 1.26A 5jt4A-4cr4H:
undetectable		 5jt4A-4cr4H:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 ALA H 438
THR H 439
GLU H 440
ALA H 426
LEU H 410
 None
 1.03A 5lf7H-4cr4H:
undetectable
5lf7I-4cr4H:
undetectable		 5lf7H-4cr4H:
19.70
5lf7I-4cr4H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 ALA H 438
THR H 439
GLU H 440
ALA H 426
LEU H 410
 None
 1.01A 5lf7V-4cr4H:
undetectable
5lf7W-4cr4H:
undetectable		 5lf7V-4cr4H:
19.70
5lf7W-4cr4H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 ILE L 262
ALA L 285
VAL L 252
ILE L 251
PRO L 247
 None
 1.25A 5mlmA-4cr4L:
undetectable		 5mlmA-4cr4L:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 VAL K 274
LEU K 299
ASP K 304
VAL K 314
ILE K 271
 None
 0.85A 5om2A-4cr4K:
undetectable
5om2B-4cr4K:
undetectable		 5om2A-4cr4K:
11.90
5om2B-4cr4K:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4cr4 26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae) 		5 / 12 ILE L 105
GLY L 102
SER L 122
THR L 147
LEU L 148
 None
 0.68A 5twjA-4cr4L:
undetectable		 5twjA-4cr4L:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 GLY K 391
ASP K 406
ARG K 396
GLN K 414
 None
 1.27A 5zrfB-4cr4K:
undetectable		 5zrfB-4cr4K:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 GLU K 199
ASP K 204
PRO K 205
 None
 0.38A 6berA-4cr4K:
undetectable		 6berA-4cr4K:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY H 253
GLN H 217
CYH H 259
VAL H 211
ASP H 210
 None
 1.44A 6bxlA-4cr4H:
undetectable		 6bxlA-4cr4H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 ASP K 148
ILE L 128
PRO K  93
LEU K  94
 None
 1.32A 6mkeB-4cr4K:
undetectable		 6mkeB-4cr4K:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 ASP K 148
ILE L 128
PRO K  93
LEU K  94
 None
 1.35A 6mkeA-4cr4K:
undetectable		 6mkeA-4cr4K:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 GLN K  90
GLU J  61
THR K 125
ARG K  81
ARG K  88
 None
 1.23A 6nknA-4cr4K:
undetectable
6nknB-4cr4K:
undetectable
6nknT-4cr4K:
undetectable		 6nknA-4cr4K:
21.30
6nknB-4cr4K:
21.77
6nknT-4cr4K:
12.26