SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 10 SER A 153
VAL A 154
TYR A 166
GLY A 197
PRO A 198
 None
 0.56A 1equA-4cr6A:
24.8		 1equA-4cr6A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 12 SER A 153
VAL A 154
TYR A 166
GLY A 197
PRO A 198
 None
 0.41A 1fdsA-4cr6A:
26.0		 1fdsA-4cr6A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 12 SER A 153
VAL A 154
TYR A 166
GLY A 197
PRO A 198
 None
 0.54A 1fduA-4cr6A:
24.9		 1fduA-4cr6A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		4 / 8 SER A 153
VAL A 154
TYR A 166
PRO A 198
 None
 0.74A 1fduB-4cr6A:
24.6		 1fduB-4cr6A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 12 SER A 153
VAL A 154
TYR A 166
GLY A 197
PRO A 198
 None
 0.50A 1fduC-4cr6A:
24.7		 1fduC-4cr6A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 11 ILE A  74
MET A  45
ILE A  19
ALA A  81
ALA A  77
 None
 1.11A 2qhfA-4cr6A:
undetectable		 2qhfA-4cr6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 12 GLY A  22
GLY A  25
ILE A 151
ALA A  93
THR A  54
 None
 1.22A 2vdvE-4cr6A:
5.2		 2vdvE-4cr6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 11 GLY A  22
GLY A  25
ILE A 151
ALA A  93
THR A  54
 None
 1.22A 2vdvF-4cr6A:
5.2		 2vdvF-4cr6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		4 / 7 GLY A 130
ILE A  74
MET A  45
LEU A  91
 None
 1.02A 2xrhA-4cr6A:
undetectable		 2xrhA-4cr6A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		4 / 7 VAL A 154
ILE A 151
GLY A  94
LEU A  68
 None
 0.88A 3bjwB-4cr6A:
undetectable		 3bjwB-4cr6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		4 / 7 VAL A 154
ILE A 151
GLY A  94
LEU A  68
 None
 0.85A 3bjwF-4cr6A:
undetectable		 3bjwF-4cr6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		4 / 7 VAL A 154
ILE A 151
GLY A  94
LEU A  68
 None
 0.82A 3bjwH-4cr6A:
undetectable		 3bjwH-4cr6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		3 / 3 ASP A  46
ARG A  50
ALA A  24
 None
 0.75A 3mbgC-4cr6A:
undetectable		 3mbgC-4cr6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 11 ILE A 194
ILE A 151
GLY A  94
VAL A 199
GLY A  26
 None
 1.09A 4ac9B-4cr6A:
6.7
4ac9C-4cr6A:
6.7		 4ac9B-4cr6A:
23.38
4ac9C-4cr6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 11 ALA A 146
SER A 145
ARG A 147
ILE A 149
ASN A 192
 None
 1.37A 4bb2A-4cr6A:
undetectable
4bb2B-4cr6A:
undetectable		 4bb2A-4cr6A:
21.70
4bb2B-4cr6A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 11 GLY A  22
THR A  31
ASP A  46
LEU A  47
ASP A  67
 None
 0.84A 4pghA-4cr6A:
7.3		 4pghA-4cr6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 12 GLY A  22
THR A  31
ASP A  46
LEU A  47
ASP A  67
 None
 0.99A 4pghB-4cr6A:
7.1		 4pghB-4cr6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		4 / 6 GLU A 231
GLY A 264
ASP A 219
ARG A 270
 None
 0.74A 5cdpA-4cr6A:
undetectable
5cdpB-4cr6A:
3.5		 5cdpA-4cr6A:
21.99
5cdpB-4cr6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 12 ILE A  27
VAL A  32
GLU A 241
ALA A  18
LEU A  88
 None
 1.04A 5igtA-4cr6A:
undetectable		 5igtA-4cr6A:
25.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		5 / 12 SER A 153
GLU A 160
GLY A 197
PRO A 198
VAL A 199
 None
 0.80A 5jo9A-4cr6A:
26.9		 5jo9A-4cr6A:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		4 / 8 ALA A  61
ILE A  19
ALA A  18
LEU A  85
 None
 0.76A 5te8B-4cr6A:
undetectable		 5te8B-4cr6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE
(Flavobacterium
sp.
141-8) 		3 / 3 LEU A 213
ASN A 155
LEU A 258
 None
None
MAN  A1272 (-4.7A)
 0.56A 6exiD-4cr6A:
8.6		 6exiD-4cr6A:
17.70