SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4crm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		3 / 3 ASP P 575
ARG P 580
ILE P 314
 None
 0.89A 1a4gB-4crmP:
undetectable		 1a4gB-4crmP:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifA-4crmX:
undetectable		 1kifA-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifB-4crmX:
undetectable		 1kifB-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.26A 1kifC-4crmX:
undetectable		 1kifC-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifD-4crmX:
undetectable		 1kifD-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifE-4crmX:
undetectable		 1kifE-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifF-4crmX:
undetectable		 1kifF-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifG-4crmX:
undetectable		 1kifG-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifH-4crmX:
undetectable		 1kifH-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		4 / 7 PRO P 411
ALA P 353
PHE P 354
SER P 355
 None
 1.29A 1lqtA-4crmP:
undetectable		 1lqtA-4crmP:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 SER X 268
VAL X 275
PHE X 145
VAL X 158
 None
 1.46A 1o86A-4crmX:
undetectable		 1o86A-4crmX:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		4 / 6 ASN P   5
ASN P  74
ILE P  56
GLY P  57
 None
None
None
SF4  P1610 ( 4.9A)
 0.95A 1oniA-4crmP:
undetectable
1oniB-4crmP:
undetectable		 1oniA-4crmP:
14.11
1oniB-4crmP:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		4 / 6 ASN P   5
ASN P  74
ILE P  56
GLY P  57
 None
None
None
SF4  P1610 ( 4.9A)
 0.95A 1oniD-4crmP:
undetectable
1oniF-4crmP:
undetectable		 1oniD-4crmP:
14.11
1oniF-4crmP:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU X 284
MET X 407
PHE X 298
ILE X 404
TYR X 300
 None
 1.47A 1osvB-4crmX:
undetectable		 1osvB-4crmX:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP X 240
LEU X 243
HIS X 167
 None
 0.79A 1qknA-4crmX:
undetectable		 1qknA-4crmX:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY X 220
ILE X 222
VAL X 275
SER X 249
 None
 0.98A 1rs7A-4crmX:
undetectable		 1rs7A-4crmX:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY X 220
ILE X 222
VAL X 275
SER X 249
 None
 0.90A 1rs7B-4crmX:
undetectable		 1rs7B-4crmX:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.30A 1ve9A-4crmX:
undetectable		 1ve9A-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		4 / 8 TYR P 600
PHE P 601
ASN P 599
GLY P 598
 None
 1.06A 1ykiC-4crmP:
undetectable
1ykiD-4crmP:
undetectable		 1ykiC-4crmP:
17.57
1ykiD-4crmP:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.21A 2du8G-4crmX:
undetectable		 2du8G-4crmX:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.30A 2du8J-4crmX:
undetectable		 2du8J-4crmX:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		3 / 3 THR P 111
ASP P 319
SER P 578
 None
 0.75A 2nxeB-4crmP:
undetectable		 2nxeB-4crmP:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 9 VAL P 382
GLY P 607
ILE P 608
ALA P 521
ILE P 523
 None
 1.04A 3el0B-4crmP:
undetectable		 3el0B-4crmP:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ILE P 478
ILE P 523
ILE P 395
ALA P 481
VAL P 509
 None
 1.02A 3fpjA-4crmP:
undetectable		 3fpjA-4crmP:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 SER X 226
ASP X 149
ASP X 228
 None
 0.85A 3iv6A-4crmX:
undetectable		 3iv6A-4crmX:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ARG P 475
VAL P 476
ASP P 458
ILE P 457
GLU P 472
 None
 1.49A 3jayA-4crmP:
undetectable		 3jayA-4crmP:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ARG P 475
VAL P 476
ASP P 458
ILE P 457
GLU P 472
 None
 1.38A 3jb3A-4crmP:
undetectable		 3jb3A-4crmP:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 GLU X 385
VAL X 319
VAL X 314
ALA X 382
 None
 1.06A 3kp6B-4crmX:
undetectable		 3kp6B-4crmX:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		3 / 3 GLN P 127
THR P 118
LEU P 131
 None
ATP  P1609 (-3.6A)
None
 0.75A 3ondA-4crmP:
undetectable		 3ondA-4crmP:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		3 / 3 GLN P 127
THR P 118
LEU P 131
 None
ATP  P1609 (-3.6A)
None
 0.76A 3ondB-4crmP:
undetectable		 3ondB-4crmP:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS X 201
VAL X 205
HIS X 167
 None
 0.98A 3tj7A-4crmX:
undetectable		 3tj7A-4crmX:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA X 206
ALA X 203
LEU X 243
ILE X 250
LEU X 233
 None
 1.12A 3uvvB-4crmX:
undetectable		 3uvvB-4crmX:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU X 317
THR X 305
ILE X 302
GLY X 403
 None
 0.96A 4eqlA-4crmX:
undetectable		 4eqlA-4crmX:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		4 / 8 GLN P  71
ILE P  10
GLY P 296
ASN P  78
 None
 0.90A 4fgjA-4crmP:
undetectable
4fgjB-4crmP:
undetectable		 4fgjA-4crmP:
16.26
4fgjB-4crmP:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY X 220
ILE X 222
VAL X 275
SER X 249
 None
 1.06A 4kcnA-4crmX:
undetectable		 4kcnA-4crmX:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA P  81
LEU P  94
GLY P 149
LEU P 152
PHE P 156
 None
 1.20A 4kykA-4crmP:
undetectable
4kykB-4crmP:
undetectable		 4kykA-4crmP:
14.57
4kykB-4crmP:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 VAL X 363
THR X 329
GLU X 366
GLU X 367
 None
 1.06A 4l78A-4crmX:
undetectable		 4l78A-4crmX:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA P   9
ILE P  10
ASN P  78
LEU P  79
GLY P 302
 None
 0.99A 4r38A-4crmP:
undetectable		 4r38A-4crmP:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA P   9
ILE P  10
ASN P  78
LEU P  79
GLY P 302
 None
 1.00A 4r38B-4crmP:
undetectable		 4r38B-4crmP:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA P   9
ILE P  10
ASN P  78
LEU P  79
GLY P 302
 None
 0.91A 4r38C-4crmP:
undetectable		 4r38C-4crmP:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA P   9
ILE P  10
ASN P  78
LEU P  79
GLY P 302
 None
 0.92A 4r38D-4crmP:
undetectable		 4r38D-4crmP:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA P   9
ILE P  10
ASN P  78
LEU P  79
GLY P 302
 None
 0.99A 4r3aB-4crmP:
undetectable		 4r3aB-4crmP:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 LEU P 252
SER P 250
LEU P 227
GLY P 224
GLY P 225
 None
 1.10A 4yvgA-4crmP:
undetectable		 4yvgA-4crmP:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		4 / 4 LEU P 381
ARG P 511
ILE P 380
ILE P 514
 None
 1.41A 5dzk2-4crmP:
undetectable
5dzkM-4crmP:
undetectable
5dzkN-4crmP:
1.6		 5dzk2-4crmP:
1.05
5dzkM-4crmP:
15.99
5dzkN-4crmP:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP X 232
LEU X 173
ARG X 191
 None
 0.86A 5e8qA-4crmX:
undetectable		 5e8qA-4crmX:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		3 / 3 ARG P 512
THR P 449
ASP P 450
 None
 0.91A 5g5gA-4crmP:
undetectable
5g5gB-4crmP:
undetectable		 5g5gA-4crmP:
16.58
5g5gB-4crmP:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		3 / 3 GLN P 594
THR P 571
ASP P 591
 None
 0.78A 5k9dA-4crmP:
undetectable		 5k9dA-4crmP:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 SER P 249
VAL P 524
GLY P 224
ASN P 387
VAL P 254
 None
None
None
ADP  P1612 (-3.6A)
None
 1.10A 6bqgA-4crmP:
undetectable		 6bqgA-4crmP:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4crm TRANSLATION
INITIATION FACTOR
RLI1
(Saccharomyces
cerevisiae) 		5 / 12 LEU P 108
GLY P 107
ASP P 527
VAL P 283
ASP P 285
 None
 1.17A 6bxlA-4crmP:
undetectable		 6bxlA-4crmP:
20.26