SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4crn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 SER P 309
ILE P 341
PHE P 264
VAL P 403
 None
 0.91A 1kb9A-4crnP:
undetectable
1kb9C-4crnP:
undetectable
1kb9D-4crnP:
undetectable
1kb9E-4crnP:
undetectable		 1kb9A-4crnP:
22.50
1kb9C-4crnP:
20.43
1kb9D-4crnP:
19.68
1kb9E-4crnP:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		6 / 12 ILE X 404
LEU X 309
GLY X 402
GLY X 403
THR X 305
LEU X 317
 None
 1.38A 1liiA-4crnX:
undetectable		 1liiA-4crnX:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 GLY X 220
SER X 159
THR X 162
ASP X 140
 None
 0.90A 1m4iA-4crnX:
undetectable		 1m4iA-4crnX:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 ASN P 278
PHE P 264
VAL P 365
LEU P 471
THR P 470
 None
 1.08A 1oq5A-4crnP:
undetectable		 1oq5A-4crnP:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 VAL P 367
LEU P 366
HIS P 388
ASP P 269
 None
 1.08A 2ddwA-4crnP:
undetectable		 2ddwA-4crnP:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 THR P 647
VAL P 611
PHE P 581
ALA P 583
 None
 1.17A 2ij7C-4crnP:
undetectable		 2ij7C-4crnP:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 VAL X 398
THR X 399
VAL P 614
GLY P 597
 None
 1.15A 2p2fA-4crnX:
undetectable		 2p2fA-4crnX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 VAL X 398
THR X 399
VAL P 614
GLY P 597
 None
 1.15A 2p2fB-4crnX:
undetectable		 2p2fB-4crnX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 ARG P 337
GLY P 255
ILE P 533
ASN P 535
PHE P 489
 None
 1.43A 2zznB-4crnP:
undetectable		 2zznB-4crnP:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 10 GLU P 509
ILE P 355
GLY P 396
LEU P 366
ILE P 263
 None
 1.47A 3adsA-4crnP:
undetectable		 3adsA-4crnP:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 LEU X 284
VAL X 278
GLY X 160
THR X 388
ILE X 387
 None
 0.94A 3bf1A-4crnX:
4.1
3bf1B-4crnX:
5.2		 3bf1A-4crnX:
21.62
3bf1B-4crnX:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 GLY P 255
ALA P 544
GLY P 511
PRO P 492
VAL P 550
 None
 0.91A 3el4A-4crnP:
undetectable		 3el4A-4crnP:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 GLY P 255
ALA P 544
GLY P 511
PRO P 492
VAL P 550
 None
 0.91A 3el5B-4crnP:
undetectable		 3el5B-4crnP:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 PHE X 401
PHE X 298
GLY X 400
ALA P 596
ILE P 593
 None
 1.41A 3ld6A-4crnX:
undetectable		 3ld6A-4crnX:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 11 ALA P 596
GLY X 402
PHE X 386
GLY X 301
PHE X 300
 None
 1.04A 3zosA-4crnP:
undetectable
3zosB-4crnP:
undetectable		 3zosA-4crnP:
22.57
3zosB-4crnP:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 7 TYR X 277
VAL X   5
ILE X 387
ASN X   8
 None
 1.11A 4a97E-4crnX:
undetectable		 4a97E-4crnX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 TYR X 277
VAL X   5
ILE X 387
ASN X   8
 None
 1.09A 4a97C-4crnX:
undetectable		 4a97C-4crnX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 7 TYR X 277
VAL X   5
ILE X 387
ASN X   8
 None
 1.14A 4a97H-4crnX:
undetectable		 4a97H-4crnX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		3 / 3 LYS P 461
PRO P 464
LYS P 416
 None
 1.29A 4dv7L-4crnP:
2.2		 4dv7L-4crnP:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 6 GLU X 385
ILE X 318
GLU X 415
VAL X 412
 None
 1.07A 4ejwB-4crnX:
undetectable		 4ejwB-4crnX:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 VAL X 199
VAL X 147
LEU X 221
VAL X 247
VAL X 205
 None
 1.17A 4ib4A-4crnX:
undetectable		 4ib4A-4crnX:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 PHE P 665
ARG P 626
LEU P 617
VAL P 641
ILE P 642
 None
 1.49A 4k38B-4crnP:
undetectable		 4k38B-4crnP:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 GLU P 333
GLU P 548
GLU P 536
TYR P 281
 None
 1.15A 4mj8A-4crnP:
undetectable
4mj8C-4crnP:
undetectable		 4mj8A-4crnP:
16.94
4mj8C-4crnP:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 VAL P 446
ASN P 453
LEU P 454
LEU P 262
ALA P 344
 None
 1.44A 4rtbA-4crnP:
undetectable		 4rtbA-4crnP:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 5 ARG X 409
GLY X 381
ALA X 382
GLY X 312
 None
 0.95A 4u9uB-4crnX:
2.4		 4u9uB-4crnX:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 VAL P 504
GLU P 559
GLY P 501
GLY P 556
 None
 0.65A 5e26C-4crnP:
undetectable
5e26D-4crnP:
undetectable		 5e26C-4crnP:
20.78
5e26D-4crnP:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU P 391
GLY P 356
GLU P 353
VAL P 351
GLU X 258
 None
 1.31A 5f9zA-4crnP:
undetectable		 5f9zA-4crnP:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		4 / 8 THR X 164
SER X 157
THR X 162
SER X 159
 None
 0.98A 5l4eA-4crnX:
1.8
5l4eB-4crnX:
undetectable
5l4eC-4crnX:
1.9
5l4eD-4crnX:
1.0
5l4eE-4crnX:
undetectable		 5l4eA-4crnX:
22.25
5l4eB-4crnX:
22.25
5l4eC-4crnX:
22.25
5l4eD-4crnX:
22.25
5l4eE-4crnX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4crn ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX
(Saccharomyces
cerevisiae) 		5 / 12 THR X 305
LEU X 306
VAL X 319
ARG X 327
ILE X 370
 None
 1.33A 5w8aA-4crnX:
undetectable		 5w8aA-4crnX:
17.78