SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cs6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 TRP A 173
ALA A 177
VAL A 179
 None
 0.96A 1av2C-4cs6A:
undetectable
1av2D-4cs6A:
undetectable		 1av2C-4cs6A:
8.55
1av2D-4cs6A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.11A 1errB-4cs6A:
undetectable		 1errB-4cs6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 SER A  36
GLY A  41
ASN A  45
GLY A  40
ASP A 206
 None
 1.03A 1ho5A-4cs6A:
undetectable		 1ho5A-4cs6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 PHE A 261
GLY A 200
SER A 204
PHE A 202
 None
 1.37A 1icuC-4cs6A:
1.8
1icuD-4cs6A:
1.9		 1icuC-4cs6A:
23.24
1icuD-4cs6A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 TRP A 173
ALA A 177
VAL A 179
 None
 0.99A 1w5uA-4cs6A:
undetectable
1w5uB-4cs6A:
undetectable		 1w5uA-4cs6A:
8.55
1w5uB-4cs6A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 TRP A 194
GLY A 200
LEU A 166
PRO A 258
 None
 1.34A 2dqyA-4cs6A:
undetectable		 2dqyA-4cs6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.06A 2jfaA-4cs6A:
undetectable		 2jfaA-4cs6A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.07A 2qxsA-4cs6A:
undetectable		 2qxsA-4cs6A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.07A 2qxsB-4cs6A:
undetectable		 2qxsB-4cs6A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A 212
LEU A 216
PHE A 249
ALA A 227
SER A 198
 None
 1.08A 4aqlA-4cs6A:
undetectable		 4aqlA-4cs6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 ILE A  48
VAL A  38
LEU A   3
ILE A   5
 None
 0.90A 4asdA-4cs6A:
undetectable		 4asdA-4cs6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 LEU A  92
LEU A  58
ILE A  20
LEU A  66
LEU A  51
 None
 1.18A 4j24D-4cs6A:
undetectable		 4j24D-4cs6A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 7 LEU A  50
THR A  13
ILE A   5
GLY A  35
 None
 0.93A 4l39B-4cs6A:
undetectable		 4l39B-4cs6A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.07A 4xi3B-4cs6A:
undetectable		 4xi3B-4cs6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		5 / 10 GLY A 233
TYR A 231
ALA A 209
LEU A 232
LEU A 234
 None
 1.20A 4xj7A-4cs6A:
undetectable
4xj7B-4cs6A:
undetectable		 4xj7A-4cs6A:
21.07
4xj7B-4cs6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 LEU A 139
LEU A 134
LEU A  96
HIS A  32
 None
 0.97A 5gtrA-4cs6A:
undetectable		 5gtrA-4cs6A:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_A_SRYA304_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 112
ASP A 130
HIS A 185
ILE A 186
THR A 189
 None
 1.38A 5luhA-4cs6A:
37.1		 5luhA-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_A_SRYA304_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 112
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.45A 5luhA-4cs6A:
37.1		 5luhA-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_A_SRYA304_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 173
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 0.99A 5luhA-4cs6A:
37.1		 5luhA-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_A_SRYA304_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 173
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.39A 5luhA-4cs6A:
37.1		 5luhA-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
ASP A 130
TRP A 173
HIS A 185
ILE A 186
THR A 189
 None
 1.31A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
ASP A 130
TRP A 173
HIS A 185
ILE A 186
THR A 189
 None
 1.39A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 112
ASP A 130
HIS A 185
ILE A 186
THR A 189
 None
 1.39A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 112
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.46A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 173
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 0.99A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 10 GLN A 108
TRP A 173
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.39A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		4 / 8 LEU A  86
VAL A  52
LEU A  50
ILE A  31
 None
 0.93A 6cb4A-4cs6A:
undetectable		 6cb4A-4cs6A:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 ASP A  47
GLU A  87
GLN A 108
TRP A 112
THR A 189
 None
 1.03A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 12 ASP A 130
TRP A 173
ASP A 178
ASP A 182
ILE A 186
THR A 189
 None
 0.96A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 GLN A 108
LEU A 172
ASP A 182
ILE A 186
THR A 189
 None
 1.22A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 12 GLN A 108
TRP A 112
ASP A 130
ASP A 182
ILE A 186
THR A 189
 None
 1.27A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 12 GLN A 108
TRP A 112
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.47A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 12 LEU A 172
TRP A 173
ASP A 178
ASP A 182
ILE A 186
THR A 189
 None
 0.91A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		6 / 12 TRP A 173
ASP A 178
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 0.76A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 ILE A  20
VAL A  23
ILE A  48
VAL A  52
PHE A 109
 None
 1.11A 6j21A-4cs6A:
undetectable		 6j21A-4cs6A:
20.09