SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4csb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 8 ASP A  48
TYR A  85
LEU A  81
THR A  45
 None
 0.93A 1rmtD-4csbA:
undetectable		 1rmtD-4csbA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 7 GLY A 125
GLN A  40
PHE A  42
PHE A  91
 None
 1.21A 2qx4A-4csbA:
undetectable
2qx4B-4csbA:
undetectable		 2qx4A-4csbA:
20.09
2qx4B-4csbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		3 / 5 GLY A  59
GLY A 132
GLU A 134
 None
 0.41A 4z2eA-4csbA:
undetectable
4z2eD-4csbA:
undetectable		 4z2eA-4csbA:
14.83
4z2eD-4csbA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 7 GLY A  59
ASP A  60
GLY A 132
GLU A 134
 None
BOG  A1135 (-4.4A)
None
None
 0.88A 4z53A-4csbA:
undetectable
4z53B-4csbA:
undetectable		 4z53A-4csbA:
10.65
4z53B-4csbA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 7 PHE A  91
ILE A 102
GLY A 113
PHE A 104
 None
 0.89A 5h3aA-4csbA:
undetectable		 5h3aA-4csbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 7 PHE A  91
ILE A 102
GLY A 113
PHE A 104
 None
 0.89A 5x5qC-4csbA:
undetectable		 5x5qC-4csbA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 8 PHE A  91
ILE A 102
GLY A 113
PHE A 104
 None
 0.87A 5x5qF-4csbA:
undetectable		 5x5qF-4csbA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 7 PHE A  91
ARG A 111
ALA A  61
GLN A  40
 None
 1.31A 6b89A-4csbA:
undetectable		 6b89A-4csbA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		4 / 6 ALA A 119
SER A 124
GLY A 125
PHE A 104
 None
 0.89A 6f8cA-4csbA:
undetectable		 6f8cA-4csbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4csb VIRULENCE ASSOCIATED
PROTEIN VAPD
(Rhodococcus
hoagii) 		3 / 3 ARG A 111
PHE A 104
GLY A 113
 None
 0.74A 6fgdA-4csbA:
undetectable		 6fgdA-4csbA:
15.76