SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4csi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4csi CELLULASE
(Humicola
grisea) 		10 / 12 ALA A 144
TYR A 146
TYR A 172
ASP A 174
GLN A 176
GLU A 213
ASP A 215
GLU A 218
ARG A 252
ASP A 374
 PEG  A1439 (-3.6A)
PEG  A1439 (-3.9A)
None
PEG  A1439 ( 3.9A)
PEG  A1439 (-3.4A)
PEG  A1439 (-2.8A)
PEG  A1439 ( 3.9A)
PEG  A1439 (-3.5A)
None
None
 0.27A 1dy4A-4csiA:
64.4		 1dy4A-4csiA:
59.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4csi CELLULASE
(Humicola
grisea) 		4 / 8 TYR A 159
PHE A 183
ASN A 162
GLY A 155
 None
PCA  A   1 ( 3.6A)
PCA  A   1 ( 3.7A)
None
 1.05A 1ykiC-4csiA:
undetectable
1ykiD-4csiA:
undetectable		 1ykiC-4csiA:
18.14
1ykiD-4csiA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4csi CELLULASE
(Humicola
grisea) 		5 / 12 VAL A  73
THR A 209
GLY A 165
ARG A 108
TYR A 146
 PCA  A   1 ( 4.9A)
None
None
None
PEG  A1439 (-3.9A)
 1.02A 2cbrA-4csiA:
undetectable		 2cbrA-4csiA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4csi CELLULASE
(Humicola
grisea) 		3 / 3 GLY A 169
ARG A  39
TYR A 110
 None
 0.76A 2opxA-4csiA:
undetectable		 2opxA-4csiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4csi CELLULASE
(Humicola
grisea) 		5 / 12 ALA A  30
THR A  27
PHE A 128
GLY A  88
LEU A  91
 None
 1.37A 3aobC-4csiA:
undetectable		 3aobC-4csiA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4csi CELLULASE
(Humicola
grisea) 		5 / 12 ASP A  74
VAL A  73
GLY A  75
TYR A  78
HIS A  11
 None
PCA  A   1 ( 4.9A)
None
None
None
 1.30A 3hgiA-4csiA:
undetectable		 3hgiA-4csiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4csi CELLULASE
(Humicola
grisea) 		3 / 3 ARG A 398
ASP A 258
GLN A 332
 None
 0.78A 3lcvB-4csiA:
undetectable		 3lcvB-4csiA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4csi CELLULASE
(Humicola
grisea) 		3 / 3 TYR A 159
GLY A 155
ASP A 153
 None
 0.59A 3ou6C-4csiA:
undetectable		 3ou6C-4csiA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4csi CELLULASE
(Humicola
grisea) 		4 / 8 ASP A 215
GLY A 261
GLU A 218
ARG A 252
 PEG  A1439 ( 3.9A)
None
PEG  A1439 (-3.5A)
None
 0.97A 3s3nA-4csiA:
undetectable		 3s3nA-4csiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4csi CELLULASE
(Humicola
grisea) 		5 / 9 THR A  85
THR A  86
ASN A  87
GLY A  88
ASP A  89
 None
 1.44A 3sfuA-4csiA:
undetectable		 3sfuA-4csiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4csi CELLULASE
(Humicola
grisea) 		4 / 5 ILE A 287
THR A 283
THR A 284
SER A 135
 None
 1.15A 3snfA-4csiA:
undetectable		 3snfA-4csiA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4csi CELLULASE
(Humicola
grisea) 		5 / 11 GLY A 171
ALA A 166
GLY A 154
MET A 150
VAL A 366
 None
 1.27A 4c5lA-4csiA:
undetectable		 4c5lA-4csiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4csi CELLULASE
(Humicola
grisea) 		5 / 10 GLY A 171
ALA A 166
GLY A 154
MET A 150
VAL A 366
 None
 1.26A 4c5lD-4csiA:
undetectable		 4c5lD-4csiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4csi CELLULASE
(Humicola
grisea) 		5 / 10 ILE A 304
LEU A 124
GLY A 125
PHE A 293
LYS A 359
 None
 1.43A 4eb4D-4csiA:
undetectable		 4eb4D-4csiA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 4csi CELLULASE
(Humicola
grisea) 		9 / 9 ASN A 142
ALA A 144
TYR A 146
TYR A 172
ASP A 174
GLU A 213
ASP A 215
GLU A 218
TRP A 372
 PEG  A1439 ( 4.6A)
PEG  A1439 (-3.6A)
PEG  A1439 (-3.9A)
None
PEG  A1439 ( 3.9A)
PEG  A1439 (-2.8A)
PEG  A1439 ( 3.9A)
PEG  A1439 (-3.5A)
PEG  A1439 (-4.0A)
 0.49A 4ipmA-4csiA:
63.9		 4ipmA-4csiA:
55.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4csi CELLULASE
(Humicola
grisea) 		5 / 12 ASN A 328
SER A 320
VAL A 325
GLN A 338
ASP A 336
 None
 1.41A 4njgB-4csiA:
undetectable		 4njgB-4csiA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4csi CELLULASE
(Humicola
grisea) 		3 / 3 ASN A 136
ASP A 133
ASP A 282
 None
 0.83A 4obwD-4csiA:
undetectable		 4obwD-4csiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4csi CELLULASE
(Humicola
grisea) 		5 / 12 LEU A 380
GLY A 399
PHE A 386
LYS A 272
ALA A 400
 None
 1.36A 4pclB-4csiA:
undetectable		 4pclB-4csiA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4csi CELLULASE
(Humicola
grisea) 		4 / 5 TYR A 172
SER A 370
ASP A 215
ASP A 263
 None
PEG  A1439 ( 4.8A)
PEG  A1439 ( 3.9A)
None
 1.03A 4qtuB-4csiA:
undetectable		 4qtuB-4csiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4csi CELLULASE
(Humicola
grisea) 		5 / 7 THR A 283
ALA A 223
THR A 224
ALA A 225
MET A 279
 None
 1.48A 4qw0K-4csiA:
undetectable		 4qw0K-4csiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4csi CELLULASE
(Humicola
grisea) 		5 / 7 THR A 283
ALA A 223
THR A 224
ALA A 225
MET A 279
 None
 1.47A 4qw0Y-4csiA:
undetectable		 4qw0Y-4csiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4csi CELLULASE
(Humicola
grisea) 		4 / 7 ARG A 252
ARG A 268
ASP A 263
TYR A 248
 None
 1.24A 5a06A-4csiA:
undetectable		 5a06A-4csiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4csi CELLULASE
(Humicola
grisea) 		4 / 7 ARG A 252
ARG A 268
ASP A 263
TYR A 248
 None
 1.20A 5a06C-4csiA:
undetectable		 5a06C-4csiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4csi CELLULASE
(Humicola
grisea) 		4 / 7 ARG A 252
ARG A 268
ASP A 263
TYR A 248
 None
 1.23A 5a06F-4csiA:
undetectable		 5a06F-4csiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4csi CELLULASE
(Humicola
grisea) 		4 / 8 PRO A 408
ASP A 180
VAL A 105
GLY A 106
 None
 0.96A 5nzyA-4csiA:
undetectable		 5nzyA-4csiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4csi CELLULASE
(Humicola
grisea) 		3 / 3 GLU A 240
ARG A 206
TYR A 207
 None
 0.53A 5trqB-4csiA:
2.4		 5trqB-4csiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4csi CELLULASE
(Humicola
grisea) 		4 / 7 GLN A 269
GLY A 327
GLN A 292
ASP A 333
 None
 1.16A 5vlmE-4csiA:
undetectable		 5vlmE-4csiA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4csi CELLULASE
(Humicola
grisea) 		5 / 12 GLY A 138
LEU A 141
GLY A 143
ASN A 136
VAL A 420
 None
 1.13A 6mhtA-4csiA:
undetectable		 6mhtA-4csiA:
21.38