SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		4 / 4 ASP A  79
LEU A  76
GLY A  73
ARG A 114
 None
 1.31A 2j2pD-4csoA:
undetectable
2j2pE-4csoA:
undetectable		 2j2pD-4csoA:
19.74
2j2pE-4csoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		3 / 3 GLU A 137
GLU A 141
TRP A 175
 None
 1.21A 3hrdA-4csoA:
undetectable
3hrdE-4csoA:
undetectable
3hrdF-4csoA:
undetectable		 3hrdA-4csoA:
20.57
3hrdE-4csoA:
20.57
3hrdF-4csoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		4 / 8 ASP A  98
ALA A  94
GLY A 166
PRO A  43
 None
 0.77A 3nu9A-4csoA:
undetectable		 3nu9A-4csoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		4 / 7 PHE A  68
PHE A 120
ALA A  28
LEU A 107
 None
 1.03A 4ejgA-4csoA:
undetectable		 4ejgA-4csoA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		3 / 3 ARG A  26
GLN A  33
GLU A  36
 None
 0.91A 4tvtA-4csoA:
undetectable		 4tvtA-4csoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		4 / 5 PHE A 122
ILE A  38
GLN A  33
ARG A  26
 None
 1.46A 5jm4A-4csoA:
undetectable		 5jm4A-4csoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		4 / 4 PHE A 122
ILE A  38
GLN A  33
ARG A  26
 None
 1.46A 5jm4B-4csoA:
undetectable		 5jm4B-4csoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		3 / 3 HIS A  58
HIS A  48
HIS A  49
 None
 0.73A 5oexA-4csoA:
undetectable		 5oexA-4csoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		5 / 12 LEU A  81
ILE A  83
LEU A  85
SER A  86
VAL A  72
 None
 0.85A 5twjA-4csoA:
undetectable		 5twjA-4csoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		5 / 10 LEU A  81
ILE A  83
LEU A  85
SER A  86
VAL A  72
 None
 0.88A 5twjB-4csoA:
undetectable		 5twjB-4csoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		6 / 12 LEU A  81
ASP A  80
ILE A  83
LEU A  85
SER A  86
VAL A  72
 None
 1.03A 5twjC-4csoA:
undetectable		 5twjC-4csoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		5 / 12 ALA A  69
GLU A 102
LEU A 107
ILE A  38
VAL A  50
 None
 1.19A 5vlmB-4csoA:
undetectable		 5vlmB-4csoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR
(Thermoproteus
tenax) 		3 / 3 TYR A 197
ASP A 199
GLN A 202
 None
 0.66A 6g1pA-4csoA:
undetectable		 6g1pA-4csoA:
25.30