SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4csw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		3 / 3 PHE A 211
VAL A 111
TRP A  21
 None
 0.74A 2cc8A-4cswA:
0.2		 2cc8A-4cswA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		3 / 3 PHE A 211
VAL A 111
TRP A  21
 None
 0.72A 2ccbA-4cswA:
undetectable		 2ccbA-4cswA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		5 / 12 LEU A  89
PHE A  79
LEU A  44
VAL A  98
VAL A  53
 None
 1.35A 2pnjB-4cswA:
undetectable		 2pnjB-4cswA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		5 / 12 LEU A  89
PHE A  79
LEU A  44
VAL A  98
VAL A  53
 None
 1.28A 2qd4B-4cswA:
undetectable		 2qd4B-4cswA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		3 / 3 PHE A 211
VAL A 111
TRP A  21
 None
 0.73A 2vx9A-4cswA:
undetectable		 2vx9A-4cswA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 8 LEU A 319
LEU A 357
LEU A 378
ARG A 312
 None
 0.87A 2xn3A-4cswA:
undetectable
2xn3B-4cswA:
undetectable		 2xn3A-4cswA:
20.19
2xn3B-4cswA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		5 / 12 TYR A 338
HIS A 380
LEU A 384
LEU A 319
PRO A 292
 None
 1.14A 3ozwB-4cswA:
undetectable		 3ozwB-4cswA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 4 LEU A 287
GLY A 286
GLY A  52
THR A  54
 None
 0.94A 3si7A-4cswA:
undetectable		 3si7A-4cswA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 8 VAL A 121
TYR A 123
TRP A  87
LEU A  57
 None
UN9  A1391 ( 4.8A)
None
None
 0.89A 3v81A-4cswA:
undetectable		 3v81A-4cswA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 8 VAL A 121
TYR A 123
TRP A  87
LEU A  57
 None
UN9  A1391 ( 4.8A)
None
None
 0.88A 3v81C-4cswA:
undetectable		 3v81C-4cswA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		5 / 12 LEU A  44
PHE A  35
ILE A 119
VAL A  94
LEU A   3
 None
 1.12A 3w67D-4cswA:
undetectable		 3w67D-4cswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		5 / 10 LEU A  32
ILE A   7
SER A  37
THR A 206
PHE A 207
 None
None
UN9  A1392 ( 4.9A)
None
None
 1.00A 4fakA-4cswA:
undetectable		 4fakA-4cswA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 7 ILE A 316
PRO A 317
GLY A 210
GLN A  22
 None
 0.89A 4g0uB-4cswA:
undetectable		 4g0uB-4cswA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		5 / 9 PRO A 283
ILE A 280
ALA A 320
THR A 352
ALA A 315
 None
 1.18A 4oqrA-4cswA:
undetectable		 4oqrA-4cswA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 8 VAL A 121
TYR A 123
TRP A  87
LEU A  57
 None
UN9  A1391 ( 4.8A)
None
None
 0.89A 4pwdC-4cswA:
undetectable		 4pwdC-4cswA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 8 VAL A 121
TYR A 123
TRP A  87
LEU A  57
 None
UN9  A1391 ( 4.8A)
None
None
 0.90A 4q0bA-4cswA:
undetectable		 4q0bA-4cswA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 8 LEU A 166
ARG A  56
VAL A 130
HIS A 133
 None
 0.77A 4qknA-4cswA:
8.2		 4qknA-4cswA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 7 ILE A 383
LEU A 319
TYR A 338
GLY A 335
 None
 1.03A 4z69A-4cswA:
2.5		 4z69A-4cswA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		4 / 8 LEU A 340
THR A 352
LEU A 351
LEU A 331
 None
 0.72A 4z90F-4cswA:
undetectable
4z90G-4cswA:
undetectable
4z90H-4cswA:
undetectable
4z90I-4cswA:
undetectable
4z90J-4cswA:
undetectable		 4z90F-4cswA:
20.34
4z90G-4cswA:
20.34
4z90H-4cswA:
20.34
4z90I-4cswA:
20.34
4z90J-4cswA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		3 / 3 ASP A 117
ARG A 169
ARG A  56
 None
 0.70A 5eajB-4cswA:
undetectable		 5eajB-4cswA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		3 / 3 MET A 226
GLU A 270
ARG A 271
 None
 0.96A 5tjyA-4cswA:
undetectable		 5tjyA-4cswA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4csw CUPIN 4 FAMILY
PROTEIN
(Rhodothermus
marinus) 		3 / 3 MET A 226
GLU A 270
ARG A 271
 None
 0.89A 5tjzA-4cswA:
undetectable		 5tjzA-4cswA:
25.20