SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ct4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 LEU A1151
PRO A1086
VAL A1125
TRP A1124
 None
 1.33A 2hrcA-4ct4A:
undetectable		 2hrcA-4ct4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1281
LEU A1285
SER A1244
VAL A1212
TRP A1253
 None
 1.18A 2po7A-4ct4A:
undetectable		 2po7A-4ct4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1168
LEU A1217
ILE A1205
VAL A1260
LEU A1261
 None
 0.79A 3w67B-4ct4A:
undetectable		 3w67B-4ct4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1168
LEU A1217
ILE A1257
VAL A1260
LEU A1261
 None
 0.78A 3w67B-4ct4A:
undetectable		 3w67B-4ct4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1217
ILE A1205
ILE A1257
VAL A1260
LEU A1261
 None
 0.94A 3w68D-4ct4A:
undetectable		 3w68D-4ct4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1292
LYS A1283
LEU A1285
ASN A1284
LYS A1236
 None
 1.25A 4x1kA-4ct4A:
undetectable
4x1kB-4ct4A:
undetectable		 4x1kA-4ct4A:
20.77
4x1kB-4ct4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1298
GLU A1267
ASP A1269
LEU A1227
GLY A1223
 None
 1.44A 5axaA-4ct4A:
undetectable		 5axaA-4ct4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1298
GLU A1267
ASP A1269
LEU A1227
GLY A1223
 None
 1.44A 5axaC-4ct4A:
undetectable		 5axaC-4ct4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 SER A1145
LYS A1203
ALA A1200
SER A1240
 None
 0.96A 5l5fY-4ct4A:
undetectable
5l5fZ-4ct4A:
undetectable		 5l5fY-4ct4A:
19.69
5l5fZ-4ct4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1298
GLU A1267
ASP A1269
LEU A1227
GLY A1223
 None
 1.39A 5m66B-4ct4A:
undetectable		 5m66B-4ct4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1298
GLU A1267
ASP A1269
LEU A1227
GLY A1223
 None
 1.39A 5v96A-4ct4A:
undetectable		 5v96A-4ct4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1298
GLU A1267
ASP A1269
LEU A1227
GLY A1223
 None
 1.40A 5v96B-4ct4A:
undetectable		 5v96B-4ct4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1298
GLU A1267
ASP A1269
LEU A1227
GLY A1223
 None
 1.41A 5v96C-4ct4A:
undetectable		 5v96C-4ct4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1298
GLU A1267
ASP A1269
LEU A1227
GLY A1223
 None
 1.39A 5v96D-4ct4A:
undetectable		 5v96D-4ct4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA A1219
GLU A1267
LEU A1274
ILE A1278
VAL A1260
 None
 1.04A 5vlmB-4ct4A:
4.6		 5vlmB-4ct4A:
20.83