SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.11A 1gtnB-4ctaA:
undetectable
1gtnC-4ctaA:
undetectable		 1gtnB-4ctaA:
12.96
1gtnC-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.12A 1gtnH-4ctaA:
undetectable
1gtnI-4ctaA:
undetectable		 1gtnH-4ctaA:
12.96
1gtnI-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 8 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.14A 1gtnI-4ctaA:
undetectable
1gtnJ-4ctaA:
undetectable		 1gtnI-4ctaA:
12.96
1gtnJ-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.15A 1gtnM-4ctaA:
undetectable
1gtnN-4ctaA:
undetectable		 1gtnM-4ctaA:
12.96
1gtnN-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.11A 1gtnU-4ctaA:
undetectable
1gtnV-4ctaA:
undetectable		 1gtnU-4ctaA:
12.96
1gtnV-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  62
ARG A 172
ARG A 141
 None
 0.71A 1l7fA-4ctaA:
undetectable		 1l7fA-4ctaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  62
ARG A 172
ARG A 141
 None
 0.70A 1l7hA-4ctaA:
undetectable		 1l7hA-4ctaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  62
VAL A 148
TRP A 139
 None
 1.07A 1qw6A-4ctaA:
undetectable		 1qw6A-4ctaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  62
VAL A 148
TRP A 139
 None
 1.15A 1qwcA-4ctaA:
undetectable		 1qwcA-4ctaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  50
GLU A  80
ALA A  85
LEU A 147
 None
 1.04A 1sn0B-4ctaA:
undetectable
1sn0D-4ctaA:
undetectable		 1sn0B-4ctaA:
15.21
1sn0D-4ctaA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  50
GLU A  80
ALA A  85
LEU A 147
VAL A   9
 None
 1.04A 1sn5B-4ctaA:
undetectable
1sn5D-4ctaA:
undetectable		 1sn5B-4ctaA:
15.21
1sn5D-4ctaA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 147
VAL A   9
LEU A  50
GLU A  80
ALA A  85
 None
 1.05A 1sn5B-4ctaA:
undetectable
1sn5D-4ctaA:
undetectable		 1sn5B-4ctaA:
15.21
1sn5D-4ctaA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.15A 1utdT-4ctaA:
undetectable
1utdU-4ctaA:
undetectable		 1utdT-4ctaA:
12.96
1utdU-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  62
VAL A 148
TRP A 139
 None
 1.07A 1vagA-4ctaA:
undetectable		 1vagA-4ctaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  62
VAL A 148
TRP A 139
 None
 1.10A 1zviA-4ctaA:
undetectable		 1zviA-4ctaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 9 THR A  78
LEU A  70
GLY A 137
VAL A 140
ILE A 122
 None
ATP  A 400 (-3.8A)
None
None
None
 1.20A 2a1oB-4ctaA:
undetectable		 2a1oB-4ctaA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 5 VAL A  77
THR A  78
VAL A   9
GLY A  10
 None
 1.02A 2p2fA-4ctaA:
2.5		 2p2fA-4ctaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 132
GLN A 162
PRO A 159
 None
 0.96A 2qhfA-4ctaA:
undetectable		 2qhfA-4ctaA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 SER A 333
ALA A 336
ALA A 361
GLU A 325
ALA A 324
 None
 1.18A 2r2vC-4ctaA:
undetectable
2r2vF-4ctaA:
undetectable
2r2vG-4ctaA:
undetectable		 2r2vC-4ctaA:
7.32
2r2vF-4ctaA:
7.32
2r2vG-4ctaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 7 PHE A 288
LEU A 275
ALA A 250
ALA A 285
 None
None
None
SO4  A 402 (-3.9A)
 0.97A 2vcvG-4ctaA:
undetectable		 2vcvG-4ctaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A  46
ALA A  81
PRO A  49
ALA A  51
 None
 1.19A 2zgwB-4ctaA:
undetectable		 2zgwB-4ctaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 5 TYR A 335
THR A 263
PHE A 288
LEU A 337
 None
 1.19A 3qelC-4ctaA:
3.8		 3qelC-4ctaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 4 GLY A 186
GLY A 184
THR A 182
LEU A 237
 GOL  A 405 ( 4.2A)
GOL  A 405 (-3.5A)
None
None
 0.77A 3si7C-4ctaA:
undetectable
3si7D-4ctaA:
undetectable		 3si7C-4ctaA:
21.34
3si7D-4ctaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 237
GLY A 186
GLY A 184
THR A 182
 None
GOL  A 405 ( 4.2A)
GOL  A 405 (-3.5A)
None
 0.80A 3si7C-4ctaA:
undetectable
3si7D-4ctaA:
undetectable		 3si7C-4ctaA:
21.34
3si7D-4ctaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 332
GLY A 292
SER A 265
ALA A 324
ALA A 338
 None
 1.21A 3sueB-4ctaA:
undetectable		 3sueB-4ctaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 331
GLY A 291
GLY A 332
SER A 333
ALA A 262
 None
 1.23A 3sueD-4ctaA:
undetectable		 3sueD-4ctaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A 149
VAL A   9
VAL A  54
LEU A  70
 None
None
None
ATP  A 400 (-3.8A)
 1.10A 3v81C-4ctaA:
5.9		 3v81C-4ctaA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JI8_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 LYS A 181
LYS A 211
TRP A 242
 None
 1.45A 4ji8L-4ctaA:
0.0		 4ji8L-4ctaA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A  69
ASP A  76
GLY A  10
GLU A  12
 ATP  A 400 (-3.6A)
ATP  A 400 (-3.7A)
None
None
 0.94A 4koeA-4ctaA:
undetectable
4koeB-4ctaA:
3.3
4koeD-4ctaA:
2.3		 4koeA-4ctaA:
23.09
4koeB-4ctaA:
23.09
4koeD-4ctaA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 135
GLY A  68
GLY A 152
LEU A   7
LEU A 147
 None
ATP  A 400 (-3.2A)
ATP  A 400 (-3.4A)
None
None
 1.01A 4n48B-4ctaA:
undetectable		 4n48B-4ctaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 135
GLY A  68
GLY A 152
LEU A   7
LEU A 147
 None
ATP  A 400 (-3.2A)
ATP  A 400 (-3.4A)
None
None
 1.00A 4n49A-4ctaA:
undetectable		 4n49A-4ctaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A  69
ASP A  76
GLY A 152
GLU A 156
 ATP  A 400 (-3.6A)
ATP  A 400 (-3.7A)
ATP  A 400 (-3.4A)
ATP  A 400 (-3.1A)
 0.91A 4z53A-4ctaA:
3.4
4z53B-4ctaA:
3.4		 4z53A-4ctaA:
21.29
4z53B-4ctaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.07A 5eeuF-4ctaA:
undetectable
5eeuG-4ctaA:
undetectable		 5eeuF-4ctaA:
12.96
5eeuG-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.10A 5eeuI-4ctaA:
undetectable
5eeuJ-4ctaA:
undetectable		 5eeuI-4ctaA:
12.96
5eeuJ-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.13A 5eeuO-4ctaA:
undetectable
5eeuP-4ctaA:
undetectable		 5eeuO-4ctaA:
12.96
5eeuP-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.13A 5eeuQ-4ctaA:
undetectable
5eeuR-4ctaA:
undetectable		 5eeuQ-4ctaA:
12.96
5eeuR-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.07A 5eevF-4ctaA:
undetectable
5eevG-4ctaA:
undetectable		 5eevF-4ctaA:
12.96
5eevG-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.11A 5eevI-4ctaA:
undetectable
5eevJ-4ctaA:
undetectable		 5eevI-4ctaA:
12.96
5eevJ-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5eevO-4ctaA:
undetectable
5eevP-4ctaA:
undetectable		 5eevO-4ctaA:
12.96
5eevP-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.13A 5eevQ-4ctaA:
undetectable
5eevR-4ctaA:
undetectable		 5eevQ-4ctaA:
12.96
5eevR-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.07A 5eewF-4ctaA:
undetectable
5eewG-4ctaA:
undetectable		 5eewF-4ctaA:
12.96
5eewG-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.11A 5eewI-4ctaA:
undetectable
5eewJ-4ctaA:
undetectable		 5eewI-4ctaA:
12.96
5eewJ-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5eewO-4ctaA:
undetectable
5eewP-4ctaA:
undetectable		 5eewO-4ctaA:
12.96
5eewP-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5eewQ-4ctaA:
undetectable
5eewR-4ctaA:
undetectable		 5eewQ-4ctaA:
12.96
5eewR-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.07A 5eexF-4ctaA:
undetectable
5eexG-4ctaA:
undetectable		 5eexF-4ctaA:
12.96
5eexG-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5eexO-4ctaA:
undetectable
5eexP-4ctaA:
undetectable		 5eexO-4ctaA:
12.96
5eexP-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.08A 5eeyF-4ctaA:
undetectable
5eeyG-4ctaA:
undetectable		 5eeyF-4ctaA:
12.96
5eeyG-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5eeyO-4ctaA:
undetectable
5eeyP-4ctaA:
undetectable		 5eeyO-4ctaA:
12.96
5eeyP-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.08A 5eezF-4ctaA:
undetectable
5eezG-4ctaA:
undetectable		 5eezF-4ctaA:
12.96
5eezG-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5eezO-4ctaA:
undetectable
5eezP-4ctaA:
undetectable		 5eezO-4ctaA:
12.96
5eezP-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.08A 5ef0F-4ctaA:
undetectable
5ef0G-4ctaA:
undetectable		 5ef0F-4ctaA:
12.96
5ef0G-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5ef0O-4ctaA:
undetectable
5ef0P-4ctaA:
undetectable		 5ef0O-4ctaA:
12.96
5ef0P-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.08A 5ef1F-4ctaA:
undetectable
5ef1G-4ctaA:
undetectable		 5ef1F-4ctaA:
12.96
5ef1G-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5ef1O-4ctaA:
undetectable
5ef1P-4ctaA:
undetectable		 5ef1O-4ctaA:
12.96
5ef1P-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.08A 5ef2F-4ctaA:
undetectable
5ef2G-4ctaA:
undetectable		 5ef2F-4ctaA:
12.96
5ef2G-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.14A 5ef2O-4ctaA:
undetectable
5ef2P-4ctaA:
undetectable		 5ef2O-4ctaA:
12.96
5ef2P-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.08A 5ef3F-4ctaA:
undetectable
5ef3G-4ctaA:
undetectable		 5ef3F-4ctaA:
12.96
5ef3G-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 276
THR A 266
ILE A 279
THR A 271
ALA A 388
 None
 1.15A 5ef3O-4ctaA:
undetectable
5ef3P-4ctaA:
undetectable		 5ef3O-4ctaA:
12.96
5ef3P-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  62
VAL A 148
TRP A 139
 None
 1.20A 5fvoA-4ctaA:
undetectable		 5fvoA-4ctaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		4 / 6 VAL A 298
LYS A 301
ALA A 302
GLN A 308
 None
GOL  A 404 (-2.8A)
None
None
 0.99A 5i8fA-4ctaA:
2.4		 5i8fA-4ctaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 165
VAL A 164
LEU A  30
VAL A  65
ILE A  26
 None
 1.07A 5v02B-4ctaA:
undetectable
5v02R-4ctaA:
undetectable		 5v02B-4ctaA:
12.18
5v02R-4ctaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4cta CINA-LIKE PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  82
LEU A  86
GLU A  80
ALA A  81
LEU A 147
 None
 1.16A 6f6iA-4ctaA:
undetectable
6f6iB-4ctaA:
undetectable		 6f6iA-4ctaA:
11.65
6f6iB-4ctaA:
11.80