SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ctd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 7 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.67A 1dvxB-4ctdA:
undetectable		 1dvxB-4ctdA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.71A 1ictB-4ctdA:
undetectable		 1ictB-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.63A 1tyrA-4ctdA:
undetectable		 1tyrA-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		5 / 12 GLU A  52
GLU A 174
GLU A 192
ARG A 211
GLU A 245
 None
None
None
CL  A1272 (-3.0A)
None
 1.24A 2b0qA-4ctdA:
0.0		 2b0qA-4ctdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 ASP A 220
PHE A 221
THR A 190
GLU A 192
 None
 1.27A 2dttB-4ctdA:
undetectable
2dttC-4ctdA:
2.1		 2dttB-4ctdA:
23.83
2dttC-4ctdA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.73A 2roxB-4ctdA:
undetectable		 2roxB-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 5 GLY A  95
TYR A  50
TYR A  94
GLU A  52
 None
 1.46A 4ae1B-4ctdA:
undetectable		 4ae1B-4ctdA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.65A 4i89A-4ctdA:
undetectable		 4i89A-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 8 TYR A  50
ARG A  68
ARG A  92
ARG A 111
 None
CL  A1271 ( 3.6A)
CL  A1271 (-2.7A)
CL  A1271 ( 4.3A)
 1.27A 4kr4C-4ctdA:
5.7		 4kr4C-4ctdA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 GLU A 241
TYR A  14
GLU A  15
GLU A  31
 CL  A1273 (-3.9A)
None
None
None
 1.32A 4mi4A-4ctdA:
undetectable		 4mi4A-4ctdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 5 SER A 239
GLY A 263
GLU A 241
PHE A 227
 CL  A1273 (-3.3A)
None
CL  A1273 (-3.9A)
None
 1.28A 4r82A-4ctdA:
undetectable
4r82B-4ctdA:
undetectable		 4r82A-4ctdA:
22.02
4r82B-4ctdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.63A 5bojA-4ctdA:
undetectable		 5bojA-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 7 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.62A 5bojB-4ctdA:
undetectable		 5bojB-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_C_ACTC1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 4 MET A  13
SER A  33
VAL A  34
GLY A  11
 CL  A1273 (-3.9A)
CL  A1280 ( 4.5A)
C8E  A1277 ( 4.6A)
C8E  A1277 ( 4.0A)
 1.39A 5k50C-4ctdA:
0.0		 5k50C-4ctdA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.65A 5l4iA-4ctdA:
undetectable		 5l4iA-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 6 LEU A 167
ALA A 195
LEU A 197
THR A 210
 None
None
None
CL  A1274 (-4.2A)
 0.64A 5l4iB-4ctdA:
undetectable		 5l4iB-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		5 / 9 LEU A 157
VAL A 169
ILE A 212
GLY A 213
LEU A 214
 None
 0.99A 5vkqC-4ctdA:
undetectable
5vkqD-4ctdA:
undetectable		 5vkqC-4ctdA:
9.74
5vkqD-4ctdA:
9.74