SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503
(Archaeoglobus
fulgidus;
Escherichia
coli) 		3 / 3 ARG A 282
VAL A 303
THR A 290
 None
 0.80A 3k4vA-4ctiA:
undetectable		 3k4vA-4ctiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503
(Archaeoglobus
fulgidus;
Escherichia
coli) 		3 / 3 ARG A 282
VAL A 303
THR A 290
 None
 0.70A 3k4vD-4ctiA:
undetectable		 3k4vD-4ctiA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503
(Escherichia
coli;
Archaeoglobus
fulgidus) 		3 / 3 HIS A 432
HIS A 515
ILE A 436
 None
 0.77A 3u52A-4ctiA:
undetectable
3u52C-4ctiA:
undetectable		 3u52A-4ctiA:
21.06
3u52C-4ctiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503
(Archaeoglobus
fulgidus;
Escherichia
coli) 		5 / 12 LEU A 503
GLY A 504
GLN A 382
ILE A 531
VAL A 470
 None
 1.27A 4okwA-4ctiA:
undetectable		 4okwA-4ctiA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 5 ILE A 531
LEU A 404
HIS A 515
VAL A 512
 None
 1.21A 5jmnB-4ctiA:
2.8		 5jmnB-4ctiA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503
(Archaeoglobus
fulgidus;
Escherichia
coli) 		5 / 10 ASP A 385
GLU A 381
LEU A 335
ALA A 338
SER A 341
 None
 1.20A 5m5cE-4ctiA:
undetectable		 5m5cE-4ctiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 6 LEU A 287
SER A 288
PHE A 291
ASP A 292
 None
 0.71A 5om3A-4ctiA:
undetectable
5om3B-4ctiA:
undetectable		 5om3A-4ctiA:
13.75
5om3B-4ctiA:
10.53