SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4cu5 ENDOLYSIN
(Clostridium
virus
phiCD27) 		5 / 12 PHE A 267
LEU A 261
THR A 260
ASP A 256
GLY A 234
 None
 1.17A 4qb9E-4cu5A:
undetectable		 4qb9E-4cu5A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4cu5 ENDOLYSIN
(Clostridium
virus
phiCD27) 		5 / 12 GLY A 195
ILE A 219
ILE A 200
SER A 201
ALA A 202
 None
 1.11A 4qtuD-4cu5A:
undetectable		 4qtuD-4cu5A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4cu5 ENDOLYSIN
(Clostridium
virus
phiCD27) 		4 / 8 THR A 260
GLY A 235
GLY A 236
ASP A 218
 None
 0.83A 4qvvK-4cu5A:
undetectable
4qvvL-4cu5A:
undetectable		 4qvvK-4cu5A:
16.67
4qvvL-4cu5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4cu5 ENDOLYSIN
(Clostridium
virus
phiCD27) 		4 / 6 LEU A 230
ILE A 241
ALA A 237
ALA A 202
 None
 0.80A 4zf8A-4cu5A:
undetectable		 4zf8A-4cu5A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4cu5 ENDOLYSIN
(Clostridium
virus
phiCD27) 		4 / 6 LYS A 240
GLY A 195
ASP A 218
ASP A 198
 None
 1.30A 5hp1A-4cu5A:
undetectable		 5hp1A-4cu5A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4cu5 ENDOLYSIN
(Clostridium
virus
phiCD27) 		5 / 12 ALA A 264
VAL A 233
GLY A 206
ILE A 250
ILE A 252
 None
 0.92A 6dh3A-4cu5A:
undetectable		 6dh3A-4cu5A:
18.89