SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 4 HIS A 308
VAL A 229
ASN A 228
THR A 304
 None
 1.46A 1dy5A-4cu8A:
undetectable		 1dy5A-4cu8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 ASP A 508
GLU A 505
ARG A 481
MET A 596
ALA A 614
 None
None
None
EDO  A1990 ( 3.9A)
EDO  A1990 (-3.4A)
 1.43A 1s14B-4cu8A:
undetectable		 1s14B-4cu8A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.31A 1v54A-4cu8A:
undetectable
1v54B-4cu8A:
undetectable
1v54T-4cu8A:
undetectable		 1v54A-4cu8A:
20.58
1v54B-4cu8A:
14.29
1v54T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.43A 1v54A-4cu8A:
undetectable
1v54B-4cu8A:
undetectable
1v54T-4cu8A:
undetectable		 1v54A-4cu8A:
20.58
1v54B-4cu8A:
14.29
1v54T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.30A 1v54G-4cu8A:
undetectable
1v54N-4cu8A:
undetectable
1v54O-4cu8A:
undetectable		 1v54G-4cu8A:
7.93
1v54N-4cu8A:
20.58
1v54O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.43A 1v54G-4cu8A:
undetectable
1v54N-4cu8A:
undetectable
1v54O-4cu8A:
undetectable		 1v54G-4cu8A:
7.93
1v54N-4cu8A:
20.58
1v54O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.28A 1v55G-4cu8A:
undetectable
1v55N-4cu8A:
undetectable
1v55O-4cu8A:
undetectable		 1v55G-4cu8A:
7.93
1v55N-4cu8A:
20.58
1v55O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.41A 1v55G-4cu8A:
undetectable
1v55N-4cu8A:
undetectable
1v55O-4cu8A:
undetectable		 1v55G-4cu8A:
7.93
1v55N-4cu8A:
20.58
1v55O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 THR A 711
VAL A 447
GLY A 454
ILE A 952
TYR A 888
 None
 1.27A 1xvaA-4cu8A:
1.9		 1xvaA-4cu8A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 VAL A 578
LEU A 581
LEU A 617
PHE A 523
ALA A 568
 None
None
None
None
EDO  A1990 (-3.4A)
 1.11A 2aylA-4cu8A:
undetectable		 2aylA-4cu8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.30A 2dyrG-4cu8A:
undetectable
2dyrN-4cu8A:
undetectable
2dyrO-4cu8A:
undetectable		 2dyrG-4cu8A:
7.93
2dyrN-4cu8A:
20.58
2dyrO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.43A 2dyrG-4cu8A:
undetectable
2dyrN-4cu8A:
undetectable
2dyrO-4cu8A:
undetectable		 2dyrG-4cu8A:
7.93
2dyrN-4cu8A:
20.58
2dyrO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.29A 2eijG-4cu8A:
undetectable
2eijN-4cu8A:
undetectable
2eijO-4cu8A:
undetectable		 2eijG-4cu8A:
7.93
2eijN-4cu8A:
20.58
2eijO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.40A 2eijG-4cu8A:
undetectable
2eijN-4cu8A:
undetectable
2eijO-4cu8A:
undetectable		 2eijG-4cu8A:
7.93
2eijN-4cu8A:
20.58
2eijO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.29A 2eikG-4cu8A:
undetectable
2eikN-4cu8A:
undetectable
2eikO-4cu8A:
undetectable		 2eikG-4cu8A:
7.93
2eikN-4cu8A:
20.58
2eikO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.41A 2eikG-4cu8A:
undetectable
2eikN-4cu8A:
undetectable
2eikO-4cu8A:
undetectable		 2eikG-4cu8A:
7.93
2eikN-4cu8A:
20.58
2eikO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.28A 2eilG-4cu8A:
undetectable
2eilN-4cu8A:
undetectable
2eilO-4cu8A:
undetectable		 2eilG-4cu8A:
7.93
2eilN-4cu8A:
20.58
2eilO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.43A 2eilG-4cu8A:
undetectable
2eilN-4cu8A:
undetectable
2eilO-4cu8A:
undetectable		 2eilG-4cu8A:
7.93
2eilN-4cu8A:
20.58
2eilO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.44A 2eimG-4cu8A:
undetectable
2eimN-4cu8A:
undetectable
2eimO-4cu8A:
undetectable		 2eimG-4cu8A:
7.93
2eimN-4cu8A:
20.58
2eimO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 6 SER A 448
GLY A 710
THR A 711
ARG A 468
 None
 1.17A 2f7fA-4cu8A:
3.7		 2f7fA-4cu8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 8 TYR A 237
TYR A 256
TYR A 290
HIS A 453
 EDO  A1989 (-4.5A)
EDO  A2007 (-4.8A)
None
None
 1.35A 2ha2A-4cu8A:
undetectable		 2ha2A-4cu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 6 PHE A 695
ARG A 697
ASN A 829
LEU A 765
 None
 1.26A 2nyrA-4cu8A:
undetectable		 2nyrA-4cu8A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 ALA A 464
GLY A 454
LYS A 933
ALA A 951
LEU A 964
 None
 1.11A 2plwA-4cu8A:
undetectable		 2plwA-4cu8A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 8 TYR A 424
THR A 331
VAL A 361
THR A 362
 None
 0.85A 2qbmA-4cu8A:
undetectable		 2qbmA-4cu8A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 ASN A 563
GLU A 564
TYR A 624
GLU A 645
TRP A 708
 DGJ  A1985 (-2.8A)
EDO  A2021 ( 3.0A)
EDO  A2021 ( 4.4A)
DGJ  A1985 (-2.9A)
DGJ  A1985 (-3.7A)
 0.63A 2v3dA-4cu8A:
15.5		 2v3dA-4cu8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 ASN A 563
GLU A 564
TYR A 624
GLU A 645
TRP A 708
 DGJ  A1985 (-2.8A)
EDO  A2021 ( 3.0A)
EDO  A2021 ( 4.4A)
DGJ  A1985 (-2.9A)
DGJ  A1985 (-3.7A)
 0.65A 2v3dB-4cu8A:
13.4		 2v3dB-4cu8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		6 / 12 SER A 625
GLY A 597
GLU A 564
VAL A 578
THR A 577
ILE A 613
 None
None
EDO  A2021 ( 3.0A)
None
None
EDO  A1990 ( 4.1A)
 1.43A 2wa2B-4cu8A:
undetectable		 2wa2B-4cu8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 5 VAL A 365
TYR A 351
VAL A 333
ASP A 381
 None
None
EDO  A2001 (-4.8A)
EDO  A2001 (-4.1A)
 1.06A 2x45A-4cu8A:
undetectable		 2x45A-4cu8A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 5 VAL A 365
TYR A 351
VAL A 333
ASP A 381
 None
None
EDO  A2001 (-4.8A)
EDO  A2001 (-4.1A)
 1.13A 2x45C-4cu8A:
undetectable		 2x45C-4cu8A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 TYR A 466
LEU A 469
LYS A 470
LEU A 500
PRO A 399
 None
 1.13A 2x7hA-4cu8A:
undetectable
2x7hB-4cu8A:
undetectable		 2x7hA-4cu8A:
18.38
2x7hB-4cu8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_G_CHDG1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.31A 2y69G-4cu8A:
undetectable
2y69N-4cu8A:
undetectable
2y69O-4cu8A:
undetectable		 2y69G-4cu8A:
7.98
2y69N-4cu8A:
20.58
2y69O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_G_CHDG1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.42A 2y69G-4cu8A:
undetectable
2y69N-4cu8A:
undetectable
2y69O-4cu8A:
undetectable		 2y69G-4cu8A:
7.98
2y69N-4cu8A:
20.58
2y69O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_T_CHDT1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.39A 2y69A-4cu8A:
undetectable
2y69B-4cu8A:
undetectable
2y69T-4cu8A:
undetectable		 2y69A-4cu8A:
20.58
2y69B-4cu8A:
14.29
2y69T-4cu8A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 ALA A 944
GLY A 949
GLY A 924
LEU A 971
ASN A 946
 None
 0.93A 2y7hB-4cu8A:
undetectable		 2y7hB-4cu8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 ALA A 944
GLY A 949
GLY A 924
LEU A 971
ASN A 946
 None
 0.92A 2y7hC-4cu8A:
undetectable		 2y7hC-4cu8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 9 ALA A 280
GLY A 294
ILE A 295
TYR A 296
HIS A 451
 None
 1.25A 2zm9A-4cu8A:
undetectable		 2zm9A-4cu8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.43A 2zxwA-4cu8A:
undetectable
2zxwB-4cu8A:
undetectable
2zxwT-4cu8A:
undetectable		 2zxwA-4cu8A:
20.58
2zxwB-4cu8A:
14.29
2zxwT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.28A 2zxwG-4cu8A:
undetectable
2zxwN-4cu8A:
undetectable
2zxwO-4cu8A:
undetectable		 2zxwG-4cu8A:
7.93
2zxwN-4cu8A:
20.58
2zxwO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.41A 2zxwG-4cu8A:
undetectable
2zxwN-4cu8A:
undetectable
2zxwO-4cu8A:
undetectable		 2zxwG-4cu8A:
7.93
2zxwN-4cu8A:
20.58
2zxwO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.32A 3abkG-4cu8A:
undetectable
3abkN-4cu8A:
0.0
3abkO-4cu8A:
undetectable		 3abkG-4cu8A:
7.93
3abkN-4cu8A:
20.58
3abkO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.44A 3abkG-4cu8A:
undetectable
3abkN-4cu8A:
0.0
3abkO-4cu8A:
undetectable		 3abkG-4cu8A:
7.93
3abkN-4cu8A:
20.58
3abkO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.30A 3ablA-4cu8A:
undetectable
3ablB-4cu8A:
undetectable
3ablT-4cu8A:
undetectable		 3ablA-4cu8A:
20.58
3ablB-4cu8A:
14.29
3ablT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.39A 3ablA-4cu8A:
undetectable
3ablB-4cu8A:
undetectable
3ablT-4cu8A:
undetectable		 3ablA-4cu8A:
20.58
3ablB-4cu8A:
14.29
3ablT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.33A 3ablG-4cu8A:
undetectable
3ablN-4cu8A:
undetectable
3ablO-4cu8A:
undetectable		 3ablG-4cu8A:
7.93
3ablN-4cu8A:
20.58
3ablO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.41A 3ablG-4cu8A:
undetectable
3ablN-4cu8A:
undetectable
3ablO-4cu8A:
undetectable		 3ablG-4cu8A:
7.93
3ablN-4cu8A:
20.58
3ablO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.29A 3abmA-4cu8A:
undetectable
3abmB-4cu8A:
undetectable
3abmT-4cu8A:
undetectable		 3abmA-4cu8A:
20.58
3abmB-4cu8A:
14.29
3abmT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.39A 3abmA-4cu8A:
undetectable
3abmB-4cu8A:
undetectable
3abmT-4cu8A:
undetectable		 3abmA-4cu8A:
20.58
3abmB-4cu8A:
14.29
3abmT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.30A 3abmG-4cu8A:
undetectable
3abmN-4cu8A:
undetectable
3abmO-4cu8A:
undetectable		 3abmG-4cu8A:
7.93
3abmN-4cu8A:
20.58
3abmO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.40A 3abmG-4cu8A:
undetectable
3abmN-4cu8A:
undetectable
3abmO-4cu8A:
undetectable		 3abmG-4cu8A:
7.93
3abmN-4cu8A:
20.58
3abmO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.28A 3ag1A-4cu8A:
undetectable
3ag1B-4cu8A:
undetectable
3ag1T-4cu8A:
undetectable		 3ag1A-4cu8A:
20.58
3ag1B-4cu8A:
14.29
3ag1T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.39A 3ag1A-4cu8A:
undetectable
3ag1B-4cu8A:
undetectable
3ag1T-4cu8A:
undetectable		 3ag1A-4cu8A:
20.58
3ag1B-4cu8A:
14.29
3ag1T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.27A 3ag1G-4cu8A:
undetectable
3ag1N-4cu8A:
undetectable
3ag1O-4cu8A:
undetectable		 3ag1G-4cu8A:
7.93
3ag1N-4cu8A:
20.58
3ag1O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.35A 3ag1G-4cu8A:
undetectable
3ag1N-4cu8A:
undetectable
3ag1O-4cu8A:
undetectable		 3ag1G-4cu8A:
7.93
3ag1N-4cu8A:
20.58
3ag1O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_G_CHDG86_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.33A 3ag2G-4cu8A:
undetectable
3ag2N-4cu8A:
undetectable
3ag2O-4cu8A:
undetectable		 3ag2G-4cu8A:
7.93
3ag2N-4cu8A:
20.58
3ag2O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_G_CHDG86_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.45A 3ag2G-4cu8A:
undetectable
3ag2N-4cu8A:
undetectable
3ag2O-4cu8A:
undetectable		 3ag2G-4cu8A:
7.93
3ag2N-4cu8A:
20.58
3ag2O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.31A 3ag3A-4cu8A:
undetectable
3ag3B-4cu8A:
undetectable
3ag3T-4cu8A:
undetectable		 3ag3A-4cu8A:
20.58
3ag3B-4cu8A:
14.29
3ag3T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.44A 3ag3A-4cu8A:
undetectable
3ag3B-4cu8A:
undetectable
3ag3T-4cu8A:
undetectable		 3ag3A-4cu8A:
20.58
3ag3B-4cu8A:
14.29
3ag3T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.35A 3ag3G-4cu8A:
undetectable
3ag3N-4cu8A:
undetectable
3ag3O-4cu8A:
undetectable		 3ag3G-4cu8A:
7.93
3ag3N-4cu8A:
20.58
3ag3O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.45A 3ag3G-4cu8A:
undetectable
3ag3N-4cu8A:
undetectable
3ag3O-4cu8A:
undetectable		 3ag3G-4cu8A:
7.93
3ag3N-4cu8A:
20.58
3ag3O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		6 / 12 GLY A 597
GLN A 503
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.40A 3ag4A-4cu8A:
undetectable
3ag4B-4cu8A:
undetectable
3ag4T-4cu8A:
undetectable		 3ag4A-4cu8A:
20.58
3ag4B-4cu8A:
14.29
3ag4T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.44A 3ag4A-4cu8A:
undetectable
3ag4B-4cu8A:
undetectable
3ag4T-4cu8A:
undetectable		 3ag4A-4cu8A:
20.58
3ag4B-4cu8A:
14.29
3ag4T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.35A 3ag4G-4cu8A:
undetectable
3ag4N-4cu8A:
undetectable
3ag4O-4cu8A:
undetectable		 3ag4G-4cu8A:
7.93
3ag4N-4cu8A:
20.58
3ag4O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.45A 3ag4G-4cu8A:
undetectable
3ag4N-4cu8A:
undetectable
3ag4O-4cu8A:
undetectable		 3ag4G-4cu8A:
7.93
3ag4N-4cu8A:
20.58
3ag4O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 GLN A 926
ALA A 739
PHE A 194
ASN A 923
ARG A 653
 None
 1.49A 3aodC-4cu8A:
undetectable		 3aodC-4cu8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 3asnA-4cu8A:
undetectable
3asnB-4cu8A:
undetectable
3asnT-4cu8A:
undetectable		 3asnA-4cu8A:
20.58
3asnB-4cu8A:
14.29
3asnT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.45A 3asnA-4cu8A:
undetectable
3asnB-4cu8A:
undetectable
3asnT-4cu8A:
undetectable		 3asnA-4cu8A:
20.58
3asnB-4cu8A:
14.29
3asnT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.31A 3asnG-4cu8A:
undetectable
3asnN-4cu8A:
undetectable
3asnO-4cu8A:
undetectable		 3asnG-4cu8A:
7.93
3asnN-4cu8A:
20.58
3asnO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.43A 3asnG-4cu8A:
undetectable
3asnN-4cu8A:
undetectable
3asnO-4cu8A:
undetectable		 3asnG-4cu8A:
7.93
3asnN-4cu8A:
20.58
3asnO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.34A 3asoA-4cu8A:
undetectable
3asoB-4cu8A:
undetectable
3asoT-4cu8A:
undetectable		 3asoA-4cu8A:
20.58
3asoB-4cu8A:
14.29
3asoT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.47A 3asoA-4cu8A:
undetectable
3asoB-4cu8A:
undetectable
3asoT-4cu8A:
undetectable		 3asoA-4cu8A:
20.58
3asoB-4cu8A:
14.29
3asoT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.33A 3asoG-4cu8A:
undetectable
3asoN-4cu8A:
undetectable
3asoO-4cu8A:
undetectable		 3asoG-4cu8A:
7.93
3asoN-4cu8A:
20.58
3asoO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.44A 3asoG-4cu8A:
undetectable
3asoN-4cu8A:
undetectable
3asoO-4cu8A:
undetectable		 3asoG-4cu8A:
7.93
3asoN-4cu8A:
20.58
3asoO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 PHE A 522
SER A 240
VAL A 281
ARG A 521
 None
 1.17A 3dqtA-4cu8A:
undetectable
3dqtB-4cu8A:
undetectable		 3dqtA-4cu8A:
19.13
3dqtB-4cu8A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 6 GLU A 564
ASN A 563
SER A 625
PHE A 601
 EDO  A2021 ( 3.0A)
DGJ  A1985 (-2.8A)
None
None
 1.17A 3i9jB-4cu8A:
undetectable		 3i9jB-4cu8A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		3 / 3 SER A 644
GLY A 621
SER A 625
 None
 0.68A 3loqA-4cu8A:
undetectable		 3loqA-4cu8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 HIS A 967
VAL A 908
ALA A 951
LEU A 964
THR A 965
 None
 1.19A 3mdzA-4cu8A:
undetectable		 3mdzA-4cu8A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 SER A 240
VAL A 281
ARG A 521
PHE A 522
 None
 1.27A 3n5tA-4cu8A:
undetectable
3n5tB-4cu8A:
undetectable		 3n5tA-4cu8A:
19.48
3n5tB-4cu8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 8 TYR A 791
ALA A 649
SER A 647
SER A 692
 None
 1.00A 3rodA-4cu8A:
undetectable		 3rodA-4cu8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.30A 3wg7A-4cu8A:
undetectable
3wg7B-4cu8A:
undetectable
3wg7T-4cu8A:
undetectable		 3wg7A-4cu8A:
20.58
3wg7B-4cu8A:
14.29
3wg7T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.46A 3wg7A-4cu8A:
undetectable
3wg7B-4cu8A:
undetectable
3wg7T-4cu8A:
undetectable		 3wg7A-4cu8A:
20.58
3wg7B-4cu8A:
14.29
3wg7T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.32A 3wg7G-4cu8A:
undetectable
3wg7N-4cu8A:
undetectable
3wg7O-4cu8A:
undetectable		 3wg7G-4cu8A:
7.93
3wg7N-4cu8A:
20.58
3wg7O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.45A 3wg7G-4cu8A:
undetectable
3wg7N-4cu8A:
undetectable
3wg7O-4cu8A:
undetectable		 3wg7G-4cu8A:
7.93
3wg7N-4cu8A:
20.58
3wg7O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.40A 3x2qA-4cu8A:
undetectable
3x2qB-4cu8A:
undetectable
3x2qT-4cu8A:
undetectable		 3x2qA-4cu8A:
20.58
3x2qB-4cu8A:
14.29
3x2qT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.42A 3x2qG-4cu8A:
undetectable
3x2qN-4cu8A:
undetectable
3x2qO-4cu8A:
undetectable		 3x2qG-4cu8A:
7.93
3x2qN-4cu8A:
20.58
3x2qO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 ILE A 565
GLY A 512
TYR A 511
GLU A 524
GLY A 520
 None
 1.26A 4bwlC-4cu8A:
10.9		 4bwlC-4cu8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 ALA A 382
LEU A 384
SER A 335
VAL A 143
TYR A 409
 None
 1.44A 4claA-4cu8A:
undetectable		 4claA-4cu8A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 734
ALA A 739
VAL A 736
GLN A 471
MET A 472
 None
None
None
EDO  A2003 (-4.2A)
None
 1.32A 4j4vA-4cu8A:
undetectable		 4j4vA-4cu8A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 734
ALA A 739
VAL A 736
GLN A 471
MET A 472
 None
None
None
EDO  A2003 (-4.2A)
None
 1.37A 4j4vB-4cu8A:
undetectable		 4j4vB-4cu8A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 734
ALA A 739
VAL A 736
GLN A 471
MET A 472
 None
None
None
EDO  A2003 (-4.2A)
None
 1.31A 4j4vD-4cu8A:
undetectable
4j4vE-4cu8A:
undetectable		 4j4vD-4cu8A:
14.46
4j4vE-4cu8A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 734
ALA A 739
VAL A 736
GLN A 471
MET A 472
 None
None
None
EDO  A2003 (-4.2A)
None
 1.33A 4j4vA-4cu8A:
undetectable
4j4vE-4cu8A:
undetectable		 4j4vA-4cu8A:
14.46
4j4vE-4cu8A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 PHE A 522
SER A 240
VAL A 281
ARG A 521
 None
 1.19A 4k5jA-4cu8A:
undetectable
4k5jB-4cu8A:
undetectable		 4k5jA-4cu8A:
19.79
4k5jB-4cu8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		3 / 3 LEU A 391
ARG A 425
MET A 558
 None
EDO  A1986 (-3.7A)
None
 0.99A 4m11C-4cu8A:
undetectable		 4m11C-4cu8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.04A 4mm4A-4cu8A:
undetectable		 4mm4A-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.05A 4mm4B-4cu8A:
undetectable		 4mm4B-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.04A 4mm6A-4cu8A:
undetectable		 4mm6A-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.11A 4mm8A-4cu8A:
undetectable		 4mm8A-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.05A 4mm9A-4cu8A:
undetectable		 4mm9A-4cu8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 VAL A 950
ALA A 951
TYR A 890
TYR A 888
GLY A 920
 None
None
EDO  A2026 ( 4.1A)
None
None
 1.01A 4mmdB-4cu8A:
undetectable		 4mmdB-4cu8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 PHE A 507
GLU A 567
ASN A 569
GLY A 570
LEU A 575
 None
None
EDO  A2014 (-4.2A)
None
None
 1.40A 4oadA-4cu8A:
undetectable		 4oadA-4cu8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 6 ILE A 190
ASP A 187
GLY A 205
HIS A 451
 None
 0.99A 4oltA-4cu8A:
undetectable		 4oltA-4cu8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 GLU A 531
PHE A 259
TYR A 252
HIS A 529
 EDO  A2000 (-3.5A)
None
None
None
 1.46A 4uciB-4cu8A:
undetectable		 4uciB-4cu8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		3 / 3 ASP A 712
GLY A 924
ASP A 922
 None
 0.61A 4xdtA-4cu8A:
undetectable		 4xdtA-4cu8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 GLY A 235
TYR A 237
SER A 240
ASN A 485
GLN A 490
 None
EDO  A1989 (-4.5A)
None
None
EDO  A2004 (-3.9A)
 1.36A 4xueB-4cu8A:
2.3		 4xueB-4cu8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 SER A 625
TYR A 624
ARG A 481
SER A 644
 None
EDO  A2021 ( 4.4A)
None
None
 1.43A 4xzkA-4cu8A:
undetectable		 4xzkA-4cu8A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 PHE A 522
SER A 240
VAL A 281
ARG A 521
 None
 1.20A 5adlA-4cu8A:
undetectable
5adlB-4cu8A:
undetectable		 5adlA-4cu8A:
19.79
5adlB-4cu8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.34A 5b1aA-4cu8A:
undetectable
5b1aB-4cu8A:
undetectable
5b1aT-4cu8A:
undetectable		 5b1aA-4cu8A:
20.58
5b1aB-4cu8A:
14.29
5b1aT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.47A 5b1aA-4cu8A:
undetectable
5b1aB-4cu8A:
undetectable
5b1aT-4cu8A:
undetectable		 5b1aA-4cu8A:
20.58
5b1aB-4cu8A:
14.29
5b1aT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.35A 5b1aG-4cu8A:
undetectable
5b1aN-4cu8A:
undetectable
5b1aO-4cu8A:
undetectable		 5b1aG-4cu8A:
7.93
5b1aN-4cu8A:
20.58
5b1aO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.46A 5b1aG-4cu8A:
undetectable
5b1aN-4cu8A:
undetectable
5b1aO-4cu8A:
undetectable		 5b1aG-4cu8A:
7.93
5b1aN-4cu8A:
20.58
5b1aO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.34A 5b1bA-4cu8A:
undetectable
5b1bB-4cu8A:
undetectable
5b1bT-4cu8A:
undetectable		 5b1bA-4cu8A:
20.58
5b1bB-4cu8A:
14.29
5b1bT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.48A 5b1bA-4cu8A:
undetectable
5b1bB-4cu8A:
undetectable
5b1bT-4cu8A:
undetectable		 5b1bA-4cu8A:
20.58
5b1bB-4cu8A:
14.29
5b1bT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.34A 5b1bG-4cu8A:
undetectable
5b1bN-4cu8A:
undetectable
5b1bO-4cu8A:
undetectable		 5b1bG-4cu8A:
7.93
5b1bN-4cu8A:
20.58
5b1bO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.47A 5b1bG-4cu8A:
undetectable
5b1bN-4cu8A:
undetectable
5b1bO-4cu8A:
undetectable		 5b1bG-4cu8A:
7.93
5b1bN-4cu8A:
20.58
5b1bO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.34A 5b3sA-4cu8A:
undetectable
5b3sB-4cu8A:
undetectable
5b3sT-4cu8A:
undetectable		 5b3sA-4cu8A:
20.58
5b3sB-4cu8A:
14.29
5b3sT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.47A 5b3sA-4cu8A:
undetectable
5b3sB-4cu8A:
undetectable
5b3sT-4cu8A:
undetectable		 5b3sA-4cu8A:
20.58
5b3sB-4cu8A:
14.29
5b3sT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.35A 5b3sG-4cu8A:
undetectable
5b3sN-4cu8A:
0.0
5b3sO-4cu8A:
undetectable		 5b3sG-4cu8A:
7.93
5b3sN-4cu8A:
20.58
5b3sO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.48A 5b3sG-4cu8A:
undetectable
5b3sN-4cu8A:
0.0
5b3sO-4cu8A:
undetectable		 5b3sG-4cu8A:
7.93
5b3sN-4cu8A:
20.58
5b3sO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 PHE A 522
SER A 240
VAL A 281
ARG A 521
 None
 1.21A 5fj3A-4cu8A:
undetectable
5fj3B-4cu8A:
undetectable		 5fj3A-4cu8A:
19.79
5fj3B-4cu8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 ASP A 540
LYS A 514
PHE A 507
GLY A 520
GLU A 524
 None
 1.34A 5hfjC-4cu8A:
undetectable		 5hfjC-4cu8A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.25A 5iy5G-4cu8A:
undetectable
5iy5N-4cu8A:
0.0
5iy5O-4cu8A:
undetectable		 5iy5G-4cu8A:
6.60
5iy5N-4cu8A:
20.58
5iy5O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.38A 5iy5G-4cu8A:
undetectable
5iy5N-4cu8A:
0.0
5iy5O-4cu8A:
undetectable		 5iy5G-4cu8A:
6.60
5iy5N-4cu8A:
20.58
5iy5O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_T_CHDT103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 5iy5A-4cu8A:
undetectable
5iy5B-4cu8A:
undetectable
5iy5T-4cu8A:
undetectable		 5iy5A-4cu8A:
20.58
5iy5B-4cu8A:
14.29
5iy5T-4cu8A:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_T_CHDT103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.37A 5iy5A-4cu8A:
undetectable
5iy5B-4cu8A:
undetectable
5iy5T-4cu8A:
undetectable		 5iy5A-4cu8A:
20.58
5iy5B-4cu8A:
14.29
5iy5T-4cu8A:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 6 ILE A 190
GLY A 924
ASN A 923
ILE A 714
 None
 0.97A 5j4nB-4cu8A:
undetectable		 5j4nB-4cu8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 8 THR A 545
ASN A 254
TYR A 252
PRO A 486
 None
EDO  A2007 ( 2.7A)
None
None
 1.04A 5v4vA-4cu8A:
10.7		 5v4vA-4cu8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 8 THR A 545
ASN A 254
TYR A 252
PRO A 486
 None
EDO  A2007 ( 2.7A)
None
None
 1.05A 5v4vB-4cu8A:
5.2		 5v4vB-4cu8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 PHE A 522
SER A 240
VAL A 281
ARG A 521
 None
 1.25A 5vv7A-4cu8A:
undetectable
5vv7B-4cu8A:
undetectable		 5vv7A-4cu8A:
19.79
5vv7B-4cu8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 PHE A 522
SER A 240
VAL A 281
ARG A 521
 None
 1.16A 5vvnA-4cu8A:
undetectable
5vvnB-4cu8A:
undetectable		 5vvnA-4cu8A:
19.79
5vvnB-4cu8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.28A 5w97G-4cu8A:
undetectable
5w97a-4cu8A:
undetectable
5w97b-4cu8A:
undetectable		 5w97G-4cu8A:
7.93
5w97a-4cu8A:
20.58
5w97b-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.40A 5w97G-4cu8A:
undetectable
5w97a-4cu8A:
undetectable
5w97b-4cu8A:
undetectable		 5w97G-4cu8A:
7.93
5w97a-4cu8A:
20.58
5w97b-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 5w97A-4cu8A:
undetectable
5w97B-4cu8A:
undetectable
5w97g-4cu8A:
undetectable		 5w97A-4cu8A:
20.58
5w97B-4cu8A:
14.29
5w97g-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.44A 5w97A-4cu8A:
undetectable
5w97B-4cu8A:
undetectable
5w97g-4cu8A:
undetectable		 5w97A-4cu8A:
20.58
5w97B-4cu8A:
14.29
5w97g-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 5wauA-4cu8A:
undetectable
5wauB-4cu8A:
undetectable
5waug-4cu8A:
undetectable		 5wauA-4cu8A:
20.58
5wauB-4cu8A:
14.29
5waug-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.41A 5wauA-4cu8A:
undetectable
5wauB-4cu8A:
undetectable
5waug-4cu8A:
undetectable		 5wauA-4cu8A:
20.58
5wauB-4cu8A:
14.29
5waug-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.41A 5wauG-4cu8A:
undetectable
5waua-4cu8A:
undetectable
5waub-4cu8A:
undetectable		 5wauG-4cu8A:
7.93
5waua-4cu8A:
20.58
5waub-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLN A 503
GLU A 505
THR A 482
PHE A 444
 None
 1.28A 5x19A-4cu8A:
undetectable
5x19B-4cu8A:
undetectable
5x19T-4cu8A:
undetectable		 5x19A-4cu8A:
20.58
5x19B-4cu8A:
14.29
5x19T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.31A 5x19A-4cu8A:
undetectable
5x19B-4cu8A:
undetectable
5x19T-4cu8A:
undetectable		 5x19A-4cu8A:
20.58
5x19B-4cu8A:
14.29
5x19T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.41A 5x19A-4cu8A:
undetectable
5x19B-4cu8A:
undetectable
5x19T-4cu8A:
undetectable		 5x19A-4cu8A:
20.58
5x19B-4cu8A:
14.29
5x19T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.30A 5x19G-4cu8A:
undetectable
5x19N-4cu8A:
undetectable
5x19O-4cu8A:
undetectable		 5x19G-4cu8A:
7.93
5x19N-4cu8A:
20.58
5x19O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.44A 5x19G-4cu8A:
undetectable
5x19N-4cu8A:
undetectable
5x19O-4cu8A:
undetectable		 5x19G-4cu8A:
7.93
5x19N-4cu8A:
20.58
5x19O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.39A 5x1bA-4cu8A:
undetectable
5x1bB-4cu8A:
undetectable
5x1bT-4cu8A:
undetectable		 5x1bA-4cu8A:
20.58
5x1bB-4cu8A:
14.29
5x1bT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		6 / 11 PHE A 444
GLY A 643
GLY A 597
GLN A 503
GLU A 505
THR A 482
 None
 1.42A 5x1bG-4cu8A:
undetectable
5x1bN-4cu8A:
undetectable
5x1bO-4cu8A:
undetectable		 5x1bG-4cu8A:
7.93
5x1bN-4cu8A:
20.58
5x1bO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.39A 5x1bG-4cu8A:
undetectable
5x1bN-4cu8A:
undetectable
5x1bO-4cu8A:
undetectable		 5x1bG-4cu8A:
7.93
5x1bN-4cu8A:
20.58
5x1bO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 5x1fA-4cu8A:
undetectable
5x1fB-4cu8A:
0.0
5x1fT-4cu8A:
0.0		 5x1fA-4cu8A:
20.58
5x1fB-4cu8A:
14.29
5x1fT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.42A 5x1fA-4cu8A:
undetectable
5x1fB-4cu8A:
0.0
5x1fT-4cu8A:
0.0		 5x1fA-4cu8A:
20.58
5x1fB-4cu8A:
14.29
5x1fT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		6 / 11 PHE A 444
GLY A 643
GLY A 597
GLN A 503
GLU A 505
THR A 482
 None
 1.37A 5x1fG-4cu8A:
undetectable
5x1fN-4cu8A:
undetectable
5x1fO-4cu8A:
undetectable		 5x1fG-4cu8A:
7.93
5x1fN-4cu8A:
20.58
5x1fO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.40A 5x1fG-4cu8A:
undetectable
5x1fN-4cu8A:
undetectable
5x1fO-4cu8A:
undetectable		 5x1fG-4cu8A:
7.93
5x1fN-4cu8A:
20.58
5x1fO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 5xdqA-4cu8A:
undetectable
5xdqB-4cu8A:
undetectable
5xdqT-4cu8A:
undetectable		 5xdqA-4cu8A:
20.58
5xdqB-4cu8A:
14.29
5xdqT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.46A 5xdqA-4cu8A:
undetectable
5xdqB-4cu8A:
undetectable
5xdqT-4cu8A:
undetectable		 5xdqA-4cu8A:
20.58
5xdqB-4cu8A:
14.29
5xdqT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.33A 5xdqG-4cu8A:
undetectable
5xdqN-4cu8A:
undetectable
5xdqO-4cu8A:
undetectable		 5xdqG-4cu8A:
7.93
5xdqN-4cu8A:
20.58
5xdqO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.44A 5xdqG-4cu8A:
undetectable
5xdqN-4cu8A:
undetectable
5xdqO-4cu8A:
undetectable		 5xdqG-4cu8A:
7.93
5xdqN-4cu8A:
20.58
5xdqO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.29A 5xdxA-4cu8A:
undetectable
5xdxB-4cu8A:
undetectable
5xdxT-4cu8A:
undetectable		 5xdxA-4cu8A:
20.58
5xdxB-4cu8A:
14.29
5xdxT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.42A 5xdxA-4cu8A:
undetectable
5xdxB-4cu8A:
undetectable
5xdxT-4cu8A:
undetectable		 5xdxA-4cu8A:
20.58
5xdxB-4cu8A:
14.29
5xdxT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_O_CHDO301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.32A 5xdxG-4cu8A:
undetectable
5xdxN-4cu8A:
undetectable
5xdxO-4cu8A:
undetectable		 5xdxG-4cu8A:
7.93
5xdxN-4cu8A:
20.58
5xdxO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_O_CHDO301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.44A 5xdxG-4cu8A:
undetectable
5xdxN-4cu8A:
undetectable
5xdxO-4cu8A:
undetectable		 5xdxG-4cu8A:
7.93
5xdxN-4cu8A:
20.58
5xdxO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 5z84A-4cu8A:
undetectable
5z84B-4cu8A:
undetectable
5z84T-4cu8A:
undetectable		 5z84A-4cu8A:
20.58
5z84B-4cu8A:
14.29
5z84T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.46A 5z84A-4cu8A:
undetectable
5z84B-4cu8A:
undetectable
5z84T-4cu8A:
undetectable		 5z84A-4cu8A:
20.58
5z84B-4cu8A:
14.29
5z84T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_G_CHDG101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.45A 5z84G-4cu8A:
undetectable
5z84N-4cu8A:
undetectable
5z84O-4cu8A:
undetectable		 5z84G-4cu8A:
7.93
5z84N-4cu8A:
20.58
5z84O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.46A 5z85G-4cu8A:
undetectable
5z85N-4cu8A:
undetectable
5z85O-4cu8A:
undetectable		 5z85G-4cu8A:
7.93
5z85N-4cu8A:
20.58
5z85O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_T_CHDT101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.33A 5z85A-4cu8A:
0.0
5z85B-4cu8A:
undetectable
5z85T-4cu8A:
undetectable		 5z85A-4cu8A:
20.58
5z85B-4cu8A:
14.29
5z85T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_T_CHDT101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.46A 5z85A-4cu8A:
0.0
5z85B-4cu8A:
undetectable
5z85T-4cu8A:
undetectable		 5z85A-4cu8A:
20.58
5z85B-4cu8A:
14.29
5z85T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.32A 5z86A-4cu8A:
undetectable
5z86B-4cu8A:
undetectable
5z86T-4cu8A:
undetectable		 5z86A-4cu8A:
20.58
5z86B-4cu8A:
14.29
5z86T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.45A 5z86A-4cu8A:
undetectable
5z86B-4cu8A:
undetectable
5z86T-4cu8A:
undetectable		 5z86A-4cu8A:
20.58
5z86B-4cu8A:
14.29
5z86T-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.33A 5z86G-4cu8A:
undetectable
5z86N-4cu8A:
0.0
5z86O-4cu8A:
undetectable		 5z86G-4cu8A:
7.93
5z86N-4cu8A:
20.58
5z86O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.46A 5z86G-4cu8A:
undetectable
5z86N-4cu8A:
0.0
5z86O-4cu8A:
undetectable		 5z86G-4cu8A:
7.93
5z86N-4cu8A:
20.58
5z86O-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.33A 5zcoA-4cu8A:
undetectable
5zcoB-4cu8A:
undetectable
5zcoT-4cu8A:
undetectable		 5zcoA-4cu8A:
20.58
5zcoB-4cu8A:
14.29
5zcoT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.45A 5zcoA-4cu8A:
undetectable
5zcoB-4cu8A:
undetectable
5zcoT-4cu8A:
undetectable		 5zcoA-4cu8A:
20.58
5zcoB-4cu8A:
14.29
5zcoT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.33A 5zcoG-4cu8A:
undetectable
5zcoN-4cu8A:
undetectable
5zcoO-4cu8A:
undetectable		 5zcoG-4cu8A:
7.93
5zcoN-4cu8A:
20.58
5zcoO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.43A 5zcoG-4cu8A:
undetectable
5zcoN-4cu8A:
undetectable
5zcoO-4cu8A:
undetectable		 5zcoG-4cu8A:
7.93
5zcoN-4cu8A:
20.58
5zcoO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.33A 5zcpA-4cu8A:
undetectable
5zcpB-4cu8A:
undetectable
5zcpT-4cu8A:
undetectable		 5zcpA-4cu8A:
20.58
5zcpB-4cu8A:
14.29
5zcpT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.45A 5zcpA-4cu8A:
undetectable
5zcpB-4cu8A:
undetectable
5zcpT-4cu8A:
undetectable		 5zcpA-4cu8A:
20.58
5zcpB-4cu8A:
14.29
5zcpT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.33A 5zcpG-4cu8A:
undetectable
5zcpN-4cu8A:
0.0
5zcpO-4cu8A:
undetectable		 5zcpG-4cu8A:
7.93
5zcpN-4cu8A:
20.58
5zcpO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.46A 5zcpG-4cu8A:
undetectable
5zcpN-4cu8A:
0.0
5zcpO-4cu8A:
undetectable		 5zcpG-4cu8A:
7.93
5zcpN-4cu8A:
20.58
5zcpO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.33A 5zcqA-4cu8A:
undetectable
5zcqB-4cu8A:
undetectable
5zcqT-4cu8A:
undetectable		 5zcqA-4cu8A:
20.58
5zcqB-4cu8A:
14.29
5zcqT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.46A 5zcqA-4cu8A:
undetectable
5zcqB-4cu8A:
undetectable
5zcqT-4cu8A:
undetectable		 5zcqA-4cu8A:
20.58
5zcqB-4cu8A:
14.29
5zcqT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.34A 5zcqG-4cu8A:
undetectable
5zcqN-4cu8A:
0.0
5zcqO-4cu8A:
undetectable		 5zcqG-4cu8A:
7.93
5zcqN-4cu8A:
20.58
5zcqO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 10 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.47A 5zcqG-4cu8A:
undetectable
5zcqN-4cu8A:
0.0
5zcqO-4cu8A:
undetectable		 5zcqG-4cu8A:
7.93
5zcqN-4cu8A:
20.58
5zcqO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 LYS A 600
GLY A 566
TRP A 510
ASP A 518
 EDO  A2014 ( 4.3A)
None
None
None
 1.40A 6ag0A-4cu8A:
5.5		 6ag0A-4cu8A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 SER A 240
VAL A 281
ARG A 521
PHE A 522
 None
 1.24A 6av6A-4cu8A:
undetectable
6av6B-4cu8A:
undetectable		 6av6A-4cu8A:
7.31
6av6B-4cu8A:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 PHE A 522
SER A 240
VAL A 281
ARG A 521
 None
 1.41A 6av6C-4cu8A:
undetectable
6av6D-4cu8A:
undetectable		 6av6C-4cu8A:
7.31
6av6D-4cu8A:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 SER A 240
VAL A 281
ARG A 521
PHE A 522
 None
 1.19A 6av7A-4cu8A:
undetectable
6av7B-4cu8A:
undetectable		 6av7A-4cu8A:
7.31
6av7B-4cu8A:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 TRP A 708
HIS A 484
THR A 483
GLU A 564
 DGJ  A1985 (-3.7A)
DGJ  A1985 ( 3.8A)
None
EDO  A2021 ( 3.0A)
 0.94A 6mn4E-4cu8A:
undetectable		 6mn4E-4cu8A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
GLU A 505
THR A 482
PHE A 444
GLY A 643
 None
 1.27A 6nknA-4cu8A:
undetectable
6nknB-4cu8A:
undetectable
6nknT-4cu8A:
undetectable		 6nknA-4cu8A:
20.58
6nknB-4cu8A:
14.29
6nknT-4cu8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 11 GLY A 597
THR A 482
THR A 483
PHE A 444
GLY A 643
 None
 1.42A 6nknA-4cu8A:
undetectable
6nknB-4cu8A:
undetectable
6nknT-4cu8A:
undetectable		 6nknA-4cu8A:
20.58
6nknB-4cu8A:
14.29
6nknT-4cu8A:
7.93