SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OSV_B_CHCB201_1 (BILE ACID RECEPTOR)	4cua	BETA-GALACTOSIDASE (Streptococcus pneumoniae)	5 / 12	LEU A1541 SER A1471 ILE A1470 PHE A1527 ILE A1620	None None EDO A2650 ( 4.8A) None None	1.40A	1osvB-4cuaA: undetectable	1osvB-4cuaA: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OT7_B_IU5B1002_1 (BILE ACID RECEPTOR)	4cua	BETA-GALACTOSIDASE (Streptococcus pneumoniae)	5 / 12	LEU A1541 SER A1471 ILE A1470 PHE A1527 ILE A1620	None None EDO A2650 ( 4.8A) None None	1.48A	1ot7B-4cuaA: undetectable	1ot7B-4cuaA: 18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EIG_A_MTXA200_2 (DIHYDROFOLATE REDUCTASE)	4cua	BETA-GALACTOSIDASE (Streptococcus pneumoniae)	4 / 5	ARG A1621 ILE A1620 VAL A1638 THR A1633	EDO A2646 (-3.8A) None None None	1.18A	3eigA-4cuaA: undetectable	3eigA-4cuaA: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W7B_B_PA1B204_1 (ACYLOXYACYL HYDROLASE SMALL SUBUNIT ACYLOXYACYL HYDROLASE LARGE SUBUNIT)	4cua	BETA-GALACTOSIDASE (Streptococcus pneumoniae)	3 / 3	GLY A1578 ASN A1585 ARG A1621	EDO A2646 (-4.1A) EDO A2646 (-3.5A) EDO A2646 (-3.8A)	0.72A	5w7bD-4cuaA: undetectable	5w7bD-4cuaA: 19.54

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1OSV_B_CHCB201_1","BILE ACID RECEPTOR","4cua","BETA-GALACTOSIDASE","Streptococcus pneumoniae",5,"LEU A1541;SER A1471;ILE A1470;PHE A1527;ILE A1620","None;None;EDO A2650 ( 4.8A);None;None","1.40A","1osvB-4cuaA:undetectable","1osvB-4cuaA:19.25"],["1OT7_B_IU5B1002_1","BILE ACID RECEPTOR","4cua","BETA-GALACTOSIDASE","Streptococcus pneumoniae",5,"LEU A1541;SER A1471;ILE A1470;PHE A1527;ILE A1620","None;None;EDO A2650 ( 4.8A);None;None","1.48A","1ot7B-4cuaA:undetectable","1ot7B-4cuaA:18.95"],["3EIG_A_MTXA200_2","DIHYDROFOLATE REDUCTASE","4cua","BETA-GALACTOSIDASE","Streptococcus pneumoniae",4,"ARG A1621;ILE A1620;VAL A1638;THR A1633","EDO A2646 (-3.8A);None;None;None","1.18A","3eigA-4cuaA:undetectable","3eigA-4cuaA:19.71"],["5W7B_B_PA1B204_1","ACYLOXYACYL HYDROLASE SMALL SUBUNIT;ACYLOXYACYL HYDROLASE LARGE SUBUNIT","4cua","BETA-GALACTOSIDASE","Streptococcus pneumoniae",3,"GLY A1578;ASN A1585;ARG A1621","EDO A2646 (-4.1A);EDO A2646 (-3.5A);EDO A2646 (-3.8A)","0.72A","5w7bD-4cuaA:undetectable","5w7bD-4cuaA:19.54"]]