SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 11 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 1.08A 1dhiB-4cukA:
undetectable		 1dhiB-4cukA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 PRO A 102
ILE A 150
GLY A 151
GLY A 153
PRO A 206
 None
NAI  A1331 (-4.9A)
NAI  A1331 (-3.6A)
NAI  A1331 (-3.2A)
NAI  A1331 (-3.5A)
 1.12A 1nv8A-4cukA:
6.2		 1nv8A-4cukA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 1.09A 1rb2B-4cukA:
undetectable		 1rb2B-4cukA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 1.03A 1rx2A-4cukA:
undetectable		 1rx2A-4cukA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		3 / 3 THR A 152
PRO A 177
TYR A 188
 None
 0.93A 2dxrA-4cukA:
2.0		 2dxrA-4cukA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		4 / 8 GLY A 153
THR A 179
ALA A 180
ALA A 181
 NAI  A1331 (-3.2A)
None
None
None
 0.57A 2ej3A-4cukA:
undetectable		 2ej3A-4cukA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		4 / 6 LEU A 194
VAL A 290
VAL A 227
ILE A 230
 None
 1.00A 2hyyA-4cukA:
undetectable		 2hyyA-4cukA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ILE A 110
LEU A 163
GLY A 165
ALA A 158
ALA A 159
 None
 1.01A 2oc8A-4cukA:
undetectable		 2oc8A-4cukA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		3 / 3 LEU A 237
ARG A 234
ILE A 238
 None
 0.69A 2xn5B-4cukA:
undetectable		 2xn5B-4cukA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 11 TYR A   6
ASN A  81
LEU A  61
ALA A  42
LEU A 315
 None
 1.43A 3jwqB-4cukA:
undetectable
3jwqC-4cukA:
undetectable		 3jwqB-4cukA:
24.32
3jwqC-4cukA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 1.08A 4dfrB-4cukA:
undetectable		 4dfrB-4cukA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 0.98A 4fhbA-4cukA:
undetectable		 4fhbA-4cukA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		4 / 8 LEU A 255
LEU A 203
HIS A 204
ILE A 110
 None
 0.93A 4ok1A-4cukA:
undetectable		 4ok1A-4cukA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 11 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 1.10A 4p66A-4cukA:
undetectable		 4p66A-4cukA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 1.01A 4pstA-4cukA:
undetectable		 4pstA-4cukA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 10 HIS A 204
LEU A 203
LEU A 163
ALA A 159
GLY A 148
 None
 1.42A 4rn6A-4cukA:
undetectable		 4rn6A-4cukA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		4 / 8 LEU A 215
ILE A 201
LEU A 255
ALA A 242
 None
 0.71A 4wboB-4cukA:
undetectable		 4wboB-4cukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ALA A 147
LEU A 194
LEU A 215
ILE A 229
THR A 146
 None
 0.97A 4x5gB-4cukA:
undetectable		 4x5gB-4cukA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		4 / 8 MET A 142
PHE A 166
ALA A 159
GLY A 165
 None
 0.83A 4xk8a-4cukA:
undetectable		 4xk8a-4cukA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ALA A 243
 None
 1.14A 5n0oA-4cukA:
undetectable		 5n0oA-4cukA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ALA A 243
 None
 1.15A 5n0rA-4cukA:
undetectable		 5n0rA-4cukA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		6 / 12 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ILE A 252
ALA A 243
 None
 1.17A 5n0sA-4cukA:
undetectable		 5n0sA-4cukA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ALA A 243
 None
 1.14A 5n0wA-4cukA:
undetectable		 5n0wA-4cukA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		6 / 12 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ILE A 252
ALA A 243
 None
 1.14A 5n0wB-4cukA:
undetectable		 5n0wB-4cukA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ILE A 238
GLY A 235
PHE A 292
ILE A 252
ALA A 243
 None
 1.12A 5n0xA-4cukA:
undetectable		 5n0xA-4cukA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		6 / 12 ILE A 238
GLY A 235
VAL A 259
PHE A 292
ILE A 252
ALA A 243
 None
 1.15A 5n4iA-4cukA:
undetectable		 5n4iA-4cukA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		4 / 7 ILE A  72
VAL A  69
ALA A  42
THR A  41
 None
 0.91A 6cduC-4cukA:
undetectable
6cduD-4cukA:
undetectable		 6cduC-4cukA:
21.35
6cduD-4cukA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4cuk D-LACTATE
DEHYDROGENASE
(Salmonella
enterica) 		4 / 7 ALA A  42
THR A  41
ILE A  72
VAL A  69
 None
 0.94A 6cduF-4cukA:
undetectable
6cduJ-4cukA:
undetectable		 6cduF-4cukA:
21.35
6cduJ-4cukA:
21.35