SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		4 / 4 LEU B 245
VAL B 250
CYH B 253
ALA B 268
 None
 1.10A 1mz9E-4cv5B:
undetectable		 1mz9E-4cv5B:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A1101
ALA A1097
ILE A1196
PRO A1072
 None
 1.12A 1oniB-4cv5A:
undetectable
1oniC-4cv5A:
undetectable		 1oniB-4cv5A:
20.28
1oniC-4cv5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A1101
ALA A1097
ILE A1196
PRO A1072
 None
 1.01A 1oniH-4cv5A:
undetectable
1oniI-4cv5A:
undetectable		 1oniH-4cv5A:
20.28
1oniI-4cv5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 183
LEU B 232
ILE B 249
THR B 247
ILE B 156
 None
 1.15A 1tw4A-4cv5B:
undetectable		 1tw4A-4cv5B:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 SER A1245
GLY A1253
ASP A1132
ASP A1126
 None
 1.14A 2oxtB-4cv5A:
undetectable		 2oxtB-4cv5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
PROTEIN CAF40
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 203
ILE A1114
ALA A1115
THR A1119
LEU B 153
 None
 0.98A 3a50D-4cv5B:
undetectable		 3a50D-4cv5B:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		3 / 3 CYH B 185
PRO B 190
ASP B 137
 None
 0.78A 3hlwB-4cv5B:
undetectable		 3hlwB-4cv5B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A1268
THR A1120
ALA A1139
ALA A1140
 None
 1.12A 3ns1C-4cv5A:
undetectable		 3ns1C-4cv5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		4 / 5 THR B 211
THR B 212
SER B 213
PHE B 218
 None
 1.06A 3snfA-4cv5B:
undetectable		 3snfA-4cv5B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
PROTEIN CAF40
(Saccharomyces
cerevisiae) 		5 / 12 THR A1118
ILE A1122
LEU B 183
VAL B 228
ILE B 156
 None
 1.24A 3sp9A-4cv5A:
undetectable		 3sp9A-4cv5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		4 / 6 TYR B 160
PHE B 208
PRO B 207
LEU B 205
 None
 1.21A 3tgvB-4cv5B:
undetectable		 3tgvB-4cv5B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		4 / 5 TYR B 160
PHE B 208
PRO B 207
LEU B 205
 None
 1.23A 3tgvC-4cv5B:
undetectable		 3tgvC-4cv5B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		4 / 6 TYR B 160
PHE B 208
PRO B 207
LEU B 205
 None
 1.27A 3tgvD-4cv5B:
undetectable		 3tgvD-4cv5B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 276
LEU B 272
ILE B 285
ASN B 297
LEU B 326
 None
 0.97A 4lmnA-4cv5B:
undetectable		 4lmnA-4cv5B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		3 / 3 HIS B 194
TRP B 143
SER B 237
 None
 1.14A 4lrhD-4cv5B:
undetectable		 4lrhD-4cv5B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		3 / 3 CYH B 185
PRO B 190
ASP B 137
 None
 0.80A 4pm5A-4cv5B:
undetectable		 4pm5A-4cv5B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4cv5 PROTEIN CAF40
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 205
LEU B 197
PHE B 243
THR B 247
 None
 0.82A 4udaA-4cv5B:
undetectable		 4udaA-4cv5B:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 THR A1210
SER A1112
SER A1111
ALA A1204
 None
 1.05A 5l5fY-4cv5A:
undetectable
5l5fZ-4cv5A:
undetectable		 5l5fY-4cv5A:
21.83
5l5fZ-4cv5A:
21.76