SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		4 / 8 PHE A 149
ILE A 160
GLY A 171
PHE A 162
 None
 0.82A 1rtsA-4cv7A:
undetectable		 1rtsA-4cv7A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		5 / 6 GLY A 171
HIS A 172
ASN A 161
ILE A 173
PHE A 149
 None
 1.45A 1xf1B-4cv7A:
undetectable		 1xf1B-4cv7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		5 / 12 GLY A  94
ALA A 129
GLY A 128
ALA A 127
VAL A  92
 None
 1.04A 2nyuA-4cv7A:
undetectable		 2nyuA-4cv7A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		4 / 7 PHE A 149
ILE A 160
GLY A 171
PHE A 162
 None
 0.88A 5h3aA-4cv7A:
undetectable		 5h3aA-4cv7A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		4 / 4 THR A 136
ASP A 138
ARG A 141
LEU A 142
 None
 0.98A 5tdmA-4cv7A:
undetectable		 5tdmA-4cv7A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		4 / 6 THR A 136
ASP A 138
ARG A 141
ASP A 145
 None
 1.18A 5tdzA-4cv7A:
undetectable		 5tdzA-4cv7A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		4 / 6 THR A 136
ASP A 138
ARG A 141
LEU A 142
 None
 1.01A 5tdzA-4cv7A:
undetectable		 5tdzA-4cv7A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB
(Rhodococcus
hoagii) 		4 / 8 PHE A 149
ILE A 160
GLY A 171
PHE A 162
 None
 0.86A 5x5qF-4cv7A:
undetectable		 5x5qF-4cv7A:
16.61