SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  51
ILE A  93
GLU A 164
LEU A 167
VAL A 162
 None
 0.93A 1cqpA-4cvhA:
4.3
1cqpB-4cvhA:
4.2		 1cqpA-4cvhA:
18.25
1cqpB-4cvhA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 8 GLU A 139
ALA A 136
LEU A 134
ALA A  48
 None
 0.91A 1ie4B-4cvhA:
undetectable
1ie4D-4cvhA:
undetectable		 1ie4B-4cvhA:
14.71
1ie4D-4cvhA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 7 CYH A 229
TYR A 226
TYR A 247
HIS A 127
 None
None
None
MG  A1452 (-4.2A)
 1.40A 1yvmA-4cvhA:
undetectable		 1yvmA-4cvhA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		4 / 8 GLU A 239
SER A 211
GLN A 215
VAL A 221
 None
 1.06A 3b9lA-4cvhA:
undetectable		 3b9lA-4cvhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 9 GLN A 283
VAL A 313
ILE A 433
VAL A 372
VAL A 370
 None
 1.18A 3fi0D-4cvhA:
undetectable		 3fi0D-4cvhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 9 GLN A 283
VAL A 313
ILE A 433
VAL A 372
VAL A 370
 None
 1.23A 3fi0F-4cvhA:
undetectable		 3fi0F-4cvhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 9 GLN A 283
VAL A 313
ILE A 433
VAL A 372
VAL A 370
 None
 1.22A 3fi0J-4cvhA:
undetectable		 3fi0J-4cvhA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 ALA A 451
LEU A 411
LEU A 302
LEU A 310
ILE A 431
 None
 1.10A 3tqbA-4cvhA:
undetectable		 3tqbA-4cvhA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		6 / 12 LEU A 134
VAL A  50
LEU A 167
ILE A 154
ILE A 222
ALA A 179
 None
 1.25A 4ltwA-4cvhA:
undetectable		 4ltwA-4cvhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens) 		5 / 11 VAL A 374
VAL A 339
VAL A 372
ILE A 431
LEU A 302
 None
 0.97A 5e4dB-4cvhA:
undetectable		 5e4dB-4cvhA:
19.51