SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 378
HIS A 379
VAL A 382
 None
 0.36A 1lqtB-4cvmA:
3.9		 1lqtB-4cvmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 378
HIS A 379
VAL A 382
 None
 0.36A 1lquB-4cvmA:
undetectable		 1lquB-4cvmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 407
LEU A 420
MET A 400
LEU A 348
 None
 1.46A 1skxA-4cvmA:
undetectable		 1skxA-4cvmA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 167
ALA A 190
GLY A 191
GLY A 109
ILE A 187
 None
 1.15A 2v7bA-4cvmA:
2.7		 2v7bA-4cvmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 207
ALA A 190
GLY A 191
GLY A 109
ILE A 187
 None
 1.23A 2v7bA-4cvmA:
2.7		 2v7bA-4cvmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 167
ALA A 190
GLY A 191
GLY A 109
ILE A 187
 None
 1.18A 2v7bB-4cvmA:
3.2		 2v7bB-4cvmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 207
ALA A 190
GLY A 191
GLY A 109
ILE A 187
 None
 1.26A 2v7bB-4cvmA:
3.2		 2v7bB-4cvmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 342
LEU A 393
LEU A 363
SER A 346
LEU A 365
 None
 1.01A 2xn7A-4cvmA:
undetectable
2xn7B-4cvmA:
undetectable		 2xn7A-4cvmA:
20.44
2xn7B-4cvmA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 165
ILE A 211
PRO A 182
VAL A 320
 None
 1.17A 2ygoA-4cvmA:
undetectable		 2ygoA-4cvmA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 THR A 108
ILE A 187
LYS A 208
PHE A 245
 None
 1.47A 4ac9C-4cvmA:
3.5		 4ac9C-4cvmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 THR A 108
ILE A 187
LYS A 208
PHE A 245
 None
 1.49A 4acbC-4cvmA:
3.9		 4acbC-4cvmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 6 GLY A 214
VAL A 177
GLY A 171
GLU A 172
TYR A 175
 None
 1.43A 4dxuA-4cvmA:
undetectable		 4dxuA-4cvmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 167
GLY A 166
GLU A 164
GLY A 191
ASN A 189
 None
None
MG  A1458 ( 2.8A)
None
ANP  A1456 (-4.4A)
 1.20A 4e47B-4cvmA:
undetectable		 4e47B-4cvmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 115
LEU A 247
GLN A 272
LEU A 271
 ANP  A1456 (-3.6A)
None
None
None
 1.11A 4ib4A-4cvmA:
undetectable		 4ib4A-4cvmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 115
LEU A 247
GLN A 272
LEU A 271
 ANP  A1456 (-3.6A)
None
None
None
 1.11A 4nc3A-4cvmA:
undetectable		 4nc3A-4cvmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 165
GLY A 166
GLU A 164
ALA A 190
 None
None
MG  A1458 ( 2.8A)
None
 0.80A 4rjdA-4cvmA:
undetectable
4rjdB-4cvmA:
undetectable		 4rjdA-4cvmA:
10.91
4rjdB-4cvmA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  10
LEU A  14
LEU A  92
ALA A  66
LEU A  67
 None
 1.18A 4wg0B-4cvmA:
undetectable
4wg0C-4cvmA:
undetectable
4wg0D-4cvmA:
undetectable		 4wg0B-4cvmA:
2.81
4wg0C-4cvmA:
2.81
4wg0D-4cvmA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  10
LEU A  14
LEU A  92
ALA A  66
LEU A  67
 None
 1.18A 4wg0D-4cvmA:
undetectable
4wg0E-4cvmA:
undetectable
4wg0F-4cvmA:
undetectable		 4wg0D-4cvmA:
2.81
4wg0E-4cvmA:
2.81
4wg0F-4cvmA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A  66
LEU A  67
LEU A  92
LEU A  10
LEU A  14
 None
 1.21A 4wg0I-4cvmA:
undetectable
4wg0J-4cvmA:
undetectable
4wg0K-4cvmA:
undetectable		 4wg0I-4cvmA:
2.81
4wg0J-4cvmA:
2.81
4wg0K-4cvmA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 SER A 246
LEU A 247
ASP A 248
LEU A 294
 None
 0.94A 4wozA-4cvmA:
undetectable
4wozB-4cvmA:
undetectable		 4wozA-4cvmA:
20.21
4wozB-4cvmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 363
ALA A 386
VAL A 382
ALA A 403
ILE A 351
 None
 1.05A 4x1yD-4cvmA:
undetectable		 4x1yD-4cvmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		4 / 4 PHE A  41
ASP A  31
GLY A  51
SER A  29
 UDP  A1452 ( 4.8A)
UDP  A1452 (-3.2A)
UDP  A1452 ( 4.0A)
None
 1.46A 4xp9C-4cvmA:
0.0		 4xp9C-4cvmA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 177
LEU A 212
ARG A 236
ILE A 187
ALA A 185
 None
 1.22A 5xprA-4cvmA:
undetectable		 5xprA-4cvmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 105
PHE A 269
VAL A 290
VAL A 280
LEU A 124
 None
 1.12A 6djzC-4cvmA:
undetectable		 6djzC-4cvmA:
21.06