SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 7 PHE A 235
GLY A 237
ILE A  81
TYR A  85
 None
 0.79A 11gsB-4cvqA:
undetectable		 11gsB-4cvqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 12 ALA A  50
ASP A  52
ILE A 296
THR A 288
ILE A  54
 None
 0.98A 1fb7A-4cvqA:
undetectable		 1fb7A-4cvqA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 11 LEU A 332
VAL A 380
ILE A  17
ILE A  40
PHE A 369
 None
None
ACT  A1405 ( 4.6A)
ACT  A1405 (-4.7A)
None
 1.40A 1gx9A-4cvqA:
undetectable		 1gx9A-4cvqA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 12 VAL A 144
ILE A 108
ILE A 161
ILE A 172
ILE A 193
 None
 1.24A 1r5lA-4cvqA:
undetectable		 1r5lA-4cvqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 6 ASP A  52
LEU A  55
VAL A  56
ILE A  59
 None
 0.69A 1s9qA-4cvqA:
undetectable		 1s9qA-4cvqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 12 GLY A 250
ILE A 108
SER A 105
ALA A 111
ILE A  98
 PLP  A1240 ( 4.9A)
None
PLP  A1240 (-2.4A)
None
None
 1.18A 1ve3A-4cvqA:
3.2		 1ve3A-4cvqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 5 PHE A 205
LEU A 231
PHE A 235
MET A 252
 None
 1.08A 1wrkB-4cvqA:
undetectable		 1wrkB-4cvqA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 5 PHE A 205
LEU A 231
PHE A 235
MET A 252
 None
 1.20A 1wrlC-4cvqA:
undetectable		 1wrlC-4cvqA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 12 HIS A  84
ALA A  80
GLY A 237
ILE A 286
ILE A 209
 None
None
None
None
PLP  A1240 (-4.4A)
 1.11A 1x1aA-4cvqA:
undetectable		 1x1aA-4cvqA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		3 / 3 TRP A 251
THR A 241
TYR A 242
 None
 0.80A 2a3aA-4cvqA:
undetectable		 2a3aA-4cvqA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		3 / 3 TRP A 251
THR A 241
TYR A 242
 None
 0.81A 2a3aB-4cvqA:
undetectable		 2a3aB-4cvqA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		3 / 3 TRP A 251
THR A 241
TYR A 242
 None
 0.80A 2a3bA-4cvqA:
undetectable		 2a3bA-4cvqA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 8 GLN A 110
LEU A 107
LEU A 268
ARG A  78
 None
 1.06A 2xn3A-4cvqA:
undetectable
2xn3B-4cvqA:
undetectable		 2xn3A-4cvqA:
22.53
2xn3B-4cvqA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 4 LEU A 332
GLN A 309
THR A 381
THR A 241
 None
 1.39A 2zj0D-4cvqA:
undetectable		 2zj0D-4cvqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		3 / 3 GLY A 103
GLY A 237
GLY A 250
 PLP  A1240 (-3.2A)
None
PLP  A1240 ( 4.9A)
 0.43A 3bogC-4cvqA:
undetectable		 3bogC-4cvqA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		3 / 3 GLY A 103
GLY A 237
GLY A 250
 PLP  A1240 (-3.2A)
None
PLP  A1240 ( 4.9A)
 0.35A 3bogD-4cvqA:
undetectable		 3bogD-4cvqA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 9 ALA A 183
SER A 186
LEU A 158
TYR A 146
ILE A 193
 None
 1.40A 3claA-4cvqA:
undetectable		 3claA-4cvqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 8 ILE A  54
PRO A  51
HIS A  84
GLY A 237
 None
 0.78A 3em0B-4cvqA:
undetectable		 3em0B-4cvqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 9 ALA A 206
ASP A 207
ILE A 203
VAL A 194
ILE A 223
 None
PLP  A1240 (-3.1A)
None
None
None
 1.08A 3ndwB-4cvqA:
undetectable		 3ndwB-4cvqA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 8 ASP A 149
SER A 151
ASP A 157
TRP A 373
 None
 1.13A 3sg9B-4cvqA:
undetectable		 3sg9B-4cvqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 5 GLN A 358
PHE A 398
LEU A  36
LYS A 360
 None
 1.27A 3sugA-4cvqA:
undetectable		 3sugA-4cvqA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 5 ILE A 203
ILE A 265
TYR A 264
GLU A 266
 None
 1.19A 4a99D-4cvqA:
undetectable		 4a99D-4cvqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 8 GLY A 366
HIS A 376
ILE A 338
PHE A 395
 None
 0.74A 4fglD-4cvqA:
undetectable		 4fglD-4cvqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_2
(SUGAR KINASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 4 SER A 222
ILE A 209
TYR A  85
PRO A 177
 None
PLP  A1240 (-4.4A)
None
None
 1.50A 4k8tA-4cvqA:
3.6		 4k8tA-4cvqA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_2
(SUGAR KINASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 4 SER A 222
ILE A 209
TYR A  85
PRO A 177
 None
PLP  A1240 (-4.4A)
None
None
 1.49A 4k93A-4cvqA:
3.9		 4k93A-4cvqA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_2
(SUGAR KINASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 4 SER A 222
ILE A 209
TYR A  85
PRO A 177
 None
PLP  A1240 (-4.4A)
None
None
 1.50A 4k93B-4cvqA:
3.4		 4k93B-4cvqA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 4 SER A 222
ILE A 209
TYR A  85
PRO A 177
 None
PLP  A1240 (-4.4A)
None
None
 1.50A 4lc4B-4cvqA:
3.5		 4lc4B-4cvqA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 5 LEU A 115
ILE A 203
LEU A 202
ARG A 170
 None
 0.80A 4mghA-4cvqA:
2.0		 4mghA-4cvqA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		5 / 11 LEU A 399
LEU A 390
LEU A  38
LEU A 363
ILE A 379
 None
 0.97A 4zowA-4cvqA:
undetectable		 4zowA-4cvqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 7 PHE A 155
GLU A 150
SER A 151
VAL A 326
 None
 1.25A 5adlA-4cvqA:
undetectable
5adlB-4cvqA:
undetectable		 5adlA-4cvqA:
22.73
5adlB-4cvqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 6 GLY A 304
GLU A 308
PHE A 299
ILE A 213
 None
 0.83A 5kmfA-4cvqA:
undetectable
5kmfC-4cvqA:
undetectable		 5kmfA-4cvqA:
20.09
5kmfC-4cvqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA
(Escherichia
coli) 		4 / 6 GLU A  29
LYS A  37
LEU A 362
LEU A 356
 None
 0.99A 5yvnA-4cvqA:
undetectable		 5yvnA-4cvqA:
20.41