SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 THR A 642
ASN A 626
HIS A 639
ASN A 640
 NAG  A1943 (-4.4A)
None
None
NAG  A1975 (-1.9A)
 0.88A 1dssR-4cvuA:
undetectable		 1dssR-4cvuA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 7 GLY A  68
SER A  70
HIS A  58
ALA A  57
 CD  A1980 ( 4.9A)
None
None
None
 0.99A 1gxsA-4cvuA:
undetectable
1gxsB-4cvuA:
undetectable		 1gxsA-4cvuA:
13.12
1gxsB-4cvuA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 GLY A 126
SER A 153
THR A  90
ASP A 122
 MAN  A1950 ( 3.7A)
None
None
None
 0.90A 1m4iA-4cvuA:
undetectable		 1m4iA-4cvuA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 TYR A 573
TYR A 575
HIS A 628
GLU A 594
 None
 1.33A 1q13A-4cvuA:
6.7		 1q13A-4cvuA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 11 ASN A 902
ALA A 903
VAL A 728
ALA A 879
VAL A 877
 None
 1.17A 1rv7A-4cvuA:
undetectable
1rv7B-4cvuA:
undetectable		 1rv7A-4cvuA:
7.22
1rv7B-4cvuA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 11 ASN A 902
ALA A 903
VAL A 728
PRO A 862
ALA A 879
 None
 1.17A 1rv7A-4cvuA:
undetectable
1rv7B-4cvuA:
undetectable		 1rv7A-4cvuA:
7.22
1rv7B-4cvuA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 SER A 694
GLY A 796
VAL A 765
ALA A 797
ARG A 699
 None
None
None
None
NAG  A1974 (-3.8A)
 1.35A 2avdB-4cvuA:
undetectable		 2avdB-4cvuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 TRP A 175
LEU A 510
LEU A 495
VAL A 179
 None
NAG  A1956 (-4.3A)
None
None
 1.10A 2dqyC-4cvuA:
undetectable		 2dqyC-4cvuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 10 GLY A 210
LEU A 112
ILE A 154
PHE A 109
LEU A  33
 None
 1.10A 2f8dA-4cvuA:
undetectable		 2f8dA-4cvuA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 10 GLY A 210
LEU A 112
ILE A 154
PHE A 109
LEU A  33
 None
 1.11A 2f8dB-4cvuA:
undetectable		 2f8dB-4cvuA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 TYR A 683
GLU A 647
HIS A 628
GLY A 644
 None
 0.95A 2ha4A-4cvuA:
undetectable		 2ha4A-4cvuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 7 TYR A 683
GLU A 647
HIS A 628
GLY A 644
 None
 0.98A 2ha4B-4cvuA:
undetectable		 2ha4B-4cvuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 THR A 231
VAL A 299
THR A 300
VAL A 272
 None
None
NAG  A1961 ( 4.4A)
None
 0.96A 2qbmA-4cvuA:
undetectable		 2qbmA-4cvuA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 ASN A 230
ARG A 474
ASP A 434
 None
None
CD  A1983 (-2.3A)
 0.93A 2qe6A-4cvuA:
1.7		 2qe6A-4cvuA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 ASN A 230
ARG A 474
ASP A 434
 None
None
CD  A1983 (-2.3A)
 0.99A 2qe6B-4cvuA:
1.6		 2qe6B-4cvuA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 TRP A 373
GLN A 700
TRP A 706
 None
 1.28A 2vqyA-4cvuA:
undetectable		 2vqyA-4cvuA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZS_A_GCSA1902_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 ASP A 201
TYR A 573
GLU A 594
TRP A 706
TRP A 717
 None
 1.08A 2vzsA-4cvuA:
26.7		 2vzsA-4cvuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZS_B_GCSB1903_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 ASP A 201
TYR A 573
GLU A 594
TRP A 706
TRP A 717
 None
 1.07A 2vzsB-4cvuA:
26.6		 2vzsB-4cvuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZV_A_GCSA1899_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 11 ASP A 201
TRP A 202
TYR A 573
TRP A 706
TRP A 717
 None
 1.10A 2vzvA-4cvuA:
26.6		 2vzvA-4cvuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZV_B_GCSB1899_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 11 ASP A 201
TRP A 202
TYR A 573
TRP A 706
TRP A 717
 None
 1.17A 2vzvB-4cvuA:
26.6		 2vzvB-4cvuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 ARG A 161
ILE A  82
LEU A  61
TYR A  89
 None
 0.95A 2ya7A-4cvuA:
undetectable		 2ya7A-4cvuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 ARG A 161
ILE A  82
LEU A  61
TYR A  89
 None
 0.96A 2ya7B-4cvuA:
undetectable		 2ya7B-4cvuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 ARG A 161
ILE A  82
LEU A  61
TYR A  89
 None
 0.97A 2ya7D-4cvuA:
undetectable		 2ya7D-4cvuA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 MET A 600
ASN A 667
SER A 619
ASN A 618
GLN A 645
 None
NAG  A1946 (-1.9A)
None
NAG  A1943 (-1.8A)
None
 1.12A 2ycjA-4cvuA:
3.5		 2ycjA-4cvuA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 THR A 642
ASN A 626
HIS A 639
ASN A 640
 NAG  A1943 (-4.4A)
None
None
NAG  A1975 (-1.9A)
 0.94A 3dmtC-4cvuA:
undetectable		 3dmtC-4cvuA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 HIS A 848
LEU A 885
ALA A 857
PRO A 851
 CD  A1990 (-3.3A)
None
None
None
 0.78A 3gv1A-4cvuA:
undetectable
3gv1C-4cvuA:
undetectable		 3gv1A-4cvuA:
9.65
3gv1C-4cvuA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 LEU A 885
ALA A 857
PRO A 851
HIS A 848
 None
None
None
CD  A1990 (-3.3A)
 0.75A 3gv1A-4cvuA:
undetectable
3gv1B-4cvuA:
undetectable		 3gv1A-4cvuA:
9.65
3gv1B-4cvuA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 7 LEU A 152
ARG A 216
PRO A 128
GLY A 111
 None
 0.91A 3hcnA-4cvuA:
undetectable		 3hcnA-4cvuA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 4 GLY A 199
GLU A 184
ASP A 201
ASP A 197
 None
 1.27A 3mb5A-4cvuA:
undetectable		 3mb5A-4cvuA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 TYR A 559
TYR A 506
GLU A 556
 NAG  A1955 (-4.6A)
None
None
 0.76A 3pfgA-4cvuA:
2.6		 3pfgA-4cvuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 TYR A 433
MET A 404
ILE A 432
SER A 445
 None
 1.17A 3pmzD-4cvuA:
undetectable		 3pmzD-4cvuA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 TYR A 748
ASP A 576
ASP A 582
 None
 0.83A 3r24A-4cvuA:
undetectable		 3r24A-4cvuA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 GLN A 219
PHE A 120
PRO A 150
LEU A 152
 None
 1.44A 3tgvB-4cvuA:
undetectable		 3tgvB-4cvuA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 SER A 424
LEU A 516
PHE A 460
VAL A 464
PHE A 490
 None
 1.44A 3u9fG-4cvuA:
undetectable
3u9fH-4cvuA:
undetectable		 3u9fG-4cvuA:
12.82
3u9fH-4cvuA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 TYR A 655
GLU A 647
TYR A 575
 None
 0.95A 3ug8A-4cvuA:
undetectable		 3ug8A-4cvuA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 ALA A 744
LEU A 753
LEU A 822
LEU A 771
ILE A 824
 None
 0.94A 3uvvA-4cvuA:
undetectable		 3uvvA-4cvuA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 4 ASN A 855
SER A 884
LEU A 885
THR A 658
 None
 1.49A 4an2A-4cvuA:
undetectable		 4an2A-4cvuA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 GLU A 686
TYR A 586
SER A 580
 None
 0.99A 4at0A-4cvuA:
undetectable		 4at0A-4cvuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 GLU A 491
TYR A 506
LEU A 510
GLU A 514
 None
None
NAG  A1956 (-4.3A)
NAG  A1956 (-2.8A)
 0.78A 4fgzB-4cvuA:
undetectable		 4fgzB-4cvuA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 5 ASN A 593
LEU A 704
LEU A 389
ASN A 709
 None
 1.28A 4n09C-4cvuA:
undetectable		 4n09C-4cvuA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 ILE A 235
ALA A 307
PHE A 348
LEU A 284
THR A 350
 None
 1.02A 4psyA-4cvuA:
undetectable		 4psyA-4cvuA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 GLY A 719
GLY A 724
ASP A 723
ASP A 710
PRO A 601
 None
 1.22A 4rtsA-4cvuA:
undetectable		 4rtsA-4cvuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 7 GLU A 381
PHE A 382
PHE A 375
HIS A 374
 CD  A1986 (-2.2A)
None
None
None
 1.29A 4uciB-4cvuA:
undetectable		 4uciB-4cvuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 ARG A 192
TYR A 427
GLU A 467
 None
 0.44A 4zzbE-4cvuA:
undetectable		 4zzbE-4cvuA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 5 SER A 733
GLN A 414
LEU A 708
PHE A 416
 None
 1.44A 5evyX-4cvuA:
undetectable		 5evyX-4cvuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 ILE A 554
PRO A 553
ILE A 546
 None
 0.45A 5hw8F-4cvuA:
undetectable		 5hw8F-4cvuA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 VAL A 330
ALA A 268
GLN A 294
VAL A 299
 None
 0.78A 5i8fA-4cvuA:
undetectable		 5i8fA-4cvuA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 ASP A 569
LEU A 481
SER A 355
GLN A 448
GLY A 487
 None
 1.24A 5m50E-4cvuA:
3.3		 5m50E-4cvuA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 HIS A 477
ASP A 437
HIS A 478
 CD  A1984 (-3.9A)
None
CD  A1984 (-4.6A)
 0.90A 5n1tW-4cvuA:
4.9		 5n1tW-4cvuA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 PHE A 898
TRP A 726
ARG A 406
GLY A 724
 None
 1.07A 5o4yA-4cvuA:
undetectable		 5o4yA-4cvuA:
1.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 TRP A  87
THR A  88
TYR A  89
THR A  39
 None
 1.41A 5tzoA-4cvuA:
2.8		 5tzoA-4cvuA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 8 TRP A  87
THR A  88
TYR A  89
THR A  39
 None
 1.37A 5tzoB-4cvuA:
2.7		 5tzoB-4cvuA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 GLU A 738
LEU A 822
ALA A 742
LEU A 771
THR A 772
 None
 0.94A 6b0cD-4cvuA:
2.9		 6b0cD-4cvuA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 PHE A 156
GLY A 210
ARG A  80
ILE A 163
GLY A 157
 None
None
None
None
NAG  A1947 (-3.2A)
 1.20A 6c2mB-4cvuA:
undetectable		 6c2mB-4cvuA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 SER A 423
ASP A 451
GLN A 195
GLU A 489
 None
 1.44A 6djzA-4cvuA:
undetectable		 6djzA-4cvuA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 GLN A  85
TYR A  44
ASN A  42
 None
NAG  A1972 ( 4.8A)
None
 0.93A 6dwdC-4cvuA:
undetectable		 6dwdC-4cvuA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		3 / 3 LEU A 226
SER A 228
PHE A 260
 None
 0.58A 6fgcA-4cvuA:
undetectable		 6fgcA-4cvuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 5 ASN A 415
GLY A 830
HIS A 739
ASP A 760
 None
 1.27A 6gh9A-4cvuA:
undetectable		 6gh9A-4cvuA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		4 / 6 PRO A 833
TRP A 762
ILE A 377
GLY A 319
 None
 1.07A 6gqiA-4cvuA:
undetectable		 6gqiA-4cvuA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4cvu BETA-MANNOSIDASE
(Trichoderma
harzianum) 		5 / 12 ASN A 626
VAL A 610
ILE A 598
THR A 605
PHE A 668
 None
 1.39A 6j20A-4cvuA:
undetectable		 6j20A-4cvuA:
18.11