SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cvy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 7 THR A 226
THR A  98
GLY A 200
ASP A 201
 None
 0.90A 1bu5A-4cvyA:
undetectable		 1bu5A-4cvyA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 8 THR A 226
THR A  98
GLY A 200
ASP A 201
 None
 0.89A 1bu5B-4cvyA:
undetectable		 1bu5B-4cvyA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 266
VAL A 267
SER A 110
ASN A 246
 None
 1.35A 1hwiC-4cvyA:
undetectable		 1hwiC-4cvyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 266
VAL A 267
SER A 110
ASN A 246
 None
 1.34A 1hwiD-4cvyA:
undetectable		 1hwiD-4cvyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 187
ASN A 246
ASP A 272
GLY A 271
THR A  66
 None
 1.05A 1r9oA-4cvyA:
undetectable		 1r9oA-4cvyA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 276
VAL A 186
GLY A 193
THR A 129
 None
 0.81A 1t7iB-4cvyA:
undetectable		 1t7iB-4cvyA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 276
VAL A 186
GLY A 193
THR A 129
 None
 0.81A 1t7jB-4cvyA:
undetectable		 1t7jB-4cvyA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  64
LEU A  38
ASP A 245
ARG A  35
GLU A 191
 None
 1.42A 2j1gE-4cvyA:
undetectable
2j1gF-4cvyA:
undetectable		 2j1gE-4cvyA:
20.32
2j1gF-4cvyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 247
TYR A 106
THR A 249
ALA A 248
 None
 1.45A 2ql8A-4cvyA:
undetectable
2ql8B-4cvyA:
undetectable		 2ql8A-4cvyA:
20.00
2ql8B-4cvyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 5 ASN A 128
ALA A 130
ALA A 131
LYS A 141
 None
 1.21A 3kp2B-4cvyA:
undetectable		 3kp2B-4cvyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 5 ASN A 128
ALA A 130
ALA A 132
LYS A 141
 None
 1.23A 3kp2B-4cvyA:
undetectable		 3kp2B-4cvyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  39
ALA A 109
GLY A 271
PRO A 190
THR A 192
 None
 1.26A 3spkA-4cvyA:
undetectable		 3spkA-4cvyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 191
ILE A 243
ALA A  40
 None
 0.60A 4wnwB-4cvyA:
undetectable		 4wnwB-4cvyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 191
ILE A 243
ALA A 248
 None
 0.38A 4wnwB-4cvyA:
undetectable		 4wnwB-4cvyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 220
LEU A 143
VAL A 185
THR A 144
 None
 0.94A 5e4dA-4cvyA:
undetectable
5e4dB-4cvyA:
undetectable		 5e4dA-4cvyA:
21.53
5e4dB-4cvyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		5 / 11 PHE A  45
ASP A 245
TRP A 126
ILE A 243
ALA A 242
 None
 1.12A 5lg3A-4cvyA:
undetectable		 5lg3A-4cvyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 194
HIS A 189
ARG A 187
 None
 0.77A 5uunA-4cvyA:
undetectable		 5uunA-4cvyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4cvy DIOXYGENASE
RV3406/MT3514
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 222
GLY A 200
HIS A  97
VAL A 100
 None
None
FE  A1293 (-3.4A)
None
 0.94A 6hu9S-4cvyA:
undetectable
6hu9q-4cvyA:
undetectable		 6hu9S-4cvyA:
14.54
6hu9q-4cvyA:
18.91