SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4cw7 PUTATIVE ADENYLATE
KINASE
(Pyrococcus
abyssi) 		3 / 3 MET A  78
MET A   1
PHE A  34
 None
 1.00A 3gn8A-4cw7A:
undetectable		 3gn8A-4cw7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4cw7 PUTATIVE ADENYLATE
KINASE
(Pyrococcus
abyssi) 		3 / 3 ARG A  96
ARG A 100
ILE A  92
 ATP  A1001 (-3.6A)
ATP  A1001 (-2.4A)
None
 0.89A 4b7qC-4cw7A:
undetectable		 4b7qC-4cw7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4cw7 PUTATIVE ADENYLATE
KINASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 161
LEU A  86
GLY A   7
VAL A 130
ILE A 131
 None
 1.05A 4c9lB-4cw7A:
undetectable		 4c9lB-4cw7A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4cw7 PUTATIVE ADENYLATE
KINASE
(Pyrococcus
abyssi) 		5 / 12 LEU A  20
LEU A  24
ILE A   3
MET A   1
GLY A 149
 None
 0.80A 4lmnA-4cw7A:
undetectable		 4lmnA-4cw7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4cw7 PUTATIVE ADENYLATE
KINASE
(Pyrococcus
abyssi) 		4 / 4 VAL A  11
GLU A 114
GLY A   7
LEU A  86
 ATP  A1001 (-4.4A)
None
None
None
 1.13A 5g5gC-4cw7A:
undetectable		 5g5gC-4cw7A:
14.04