SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		4 / 7 TYR A 224
MET A 221
ASP A 185
ASP A 220
 None
 1.44A 1t03A-4cweA:
undetectable		 1t03A-4cweA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		4 / 6 ALA A 156
PHE A 179
ILE A 188
VAL A 213
 None
 0.93A 2cizA-4cweA:
undetectable		 2cizA-4cweA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		4 / 5 ARG A 212
ALA A 144
ASP A 142
GLU A 214
 None
 1.38A 2xrzA-4cweA:
undetectable		 2xrzA-4cweA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		4 / 8 PHE A 138
ARG A 140
ALA A  47
LEU A 141
 None
 1.03A 4rkuA-4cweA:
undetectable
4rkuJ-4cweA:
undetectable		 4rkuA-4cweA:
16.67
4rkuJ-4cweA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		4 / 7 PHE A 138
ARG A 140
ALA A  47
LEU A 141
 None
 1.05A 4xk8A-4cweA:
undetectable		 4xk8A-4cweA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		4 / 7 ASN A 171
LYS A 173
LEU A 151
PHE A 147
 None
 1.17A 4yv5A-4cweA:
undetectable		 4yv5A-4cweA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		4 / 6 GLU A 216
ARG A 182
ARG A 189
ASP A 183
 None
 1.30A 5zw4A-4cweA:
undetectable		 5zw4A-4cweA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN
(Staphylococcus
aureus) 		5 / 12 PHE A  65
ILE A 129
TYR A  92
LEU A  54
MET A 133
 None
 1.21A 6r2eH-4cweA:
undetectable		 6r2eH-4cweA:
20.06