SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 5 LEU A 163
ALA A 161
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 1.08A 1tt6B-4cxfA:
undetectable		 1tt6B-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 LEU A 163
ALA A 159
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 0.97A 1tz8C-4cxfA:
undetectable
1tz8D-4cxfA:
undetectable		 1tz8C-4cxfA:
20.10
1tz8D-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		4 / 5 ARG B  12
MET A 154
THR A 149
LEU A 148
 None
 1.28A 2eimJ-4cxfB:
undetectable		 2eimJ-4cxfB:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		4 / 5 ARG B  12
MET A 154
THR A 149
LEU A 148
 None
 1.24A 2eimW-4cxfB:
undetectable		 2eimW-4cxfB:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		5 / 12 VAL B  14
HIS B  10
ALA A  36
PHE A  40
VAL A 131
 None
 1.43A 2g70A-4cxfB:
undetectable		 2g70A-4cxfB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		5 / 12 VAL B  14
HIS B  10
ALA A  36
PHE A  40
VAL A 131
 None
 1.45A 2g70B-4cxfB:
undetectable		 2g70B-4cxfB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 5 PHE A  55
PHE A  22
LEU A  62
PHE A  65
 None
 1.10A 2y69P-4cxfA:
undetectable
2y69W-4cxfA:
undetectable		 2y69P-4cxfA:
19.71
2y69W-4cxfA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 4cxf CNRY
RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		5 / 12 LEU A 138
THR A 134
TRP B   7
LEU B   8
ILE A 151
 None
 1.50A 2ydoA-4cxfA:
undetectable		 2ydoA-4cxfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		5 / 12 PHE A  40
VAL B  22
VAL A 147
LEU A 148
ILE A 151
 None
 1.30A 3elzA-4cxfA:
undetectable		 3elzA-4cxfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 LEU A 163
ALA A 161
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 1.06A 4i89A-4cxfA:
undetectable		 4i89A-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 5 LEU A 135
LEU A 138
ILE A 146
ARG A 178
 None
None
None
SO4  B1031 (-2.6A)
 0.87A 4klrA-4cxfA:
undetectable		 4klrA-4cxfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 LEU A 163
ALA A 161
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 1.07A 5bojA-4cxfA:
undetectable		 5bojA-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 8 ARG A  72
GLU A 158
PRO A  70
ASP A   5
 None
 1.14A 5kf8A-4cxfA:
undetectable		 5kf8A-4cxfA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 8 ARG A  72
GLU A 158
PRO A  70
ASP A   5
 None
 1.03A 5kgpA-4cxfA:
undetectable		 5kgpA-4cxfA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 8 ARG A  72
GLU A 158
PRO A  70
ASP A   5
 None
 1.02A 5kgpB-4cxfA:
undetectable		 5kgpB-4cxfA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 LEU A 163
ALA A 161
LEU A 165
SER A 166
 None
None
SO4  A1192 (-4.5A)
None
 1.01A 5l4iA-4cxfA:
undetectable		 5l4iA-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		5 / 12 LEU A 128
ALA A 129
ILE A 146
ALA A 150
ALA B  11
 None
 1.11A 5n5dB-4cxfA:
undetectable		 5n5dB-4cxfA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 7 VAL A 147
ARG A  84
TYR A  87
GLU A 144
 None
None
SO4  A1190 (-4.4A)
None
 1.12A 5umwB-4cxfA:
undetectable
5umwE-4cxfA:
undetectable		 5umwB-4cxfA:
19.27
5umwE-4cxfA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		4 / 5 ARG B  12
MET A 154
THR A 149
LEU A 148
 None
 1.41A 5wauJ-4cxfB:
undetectable		 5wauJ-4cxfB:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 PHE A  55
PHE A  22
LEU A  62
PHE A  65
 None
 1.07A 5z84P-4cxfA:
undetectable
5z84W-4cxfA:
undetectable		 5z84P-4cxfA:
19.71
5z84W-4cxfA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 PHE A  55
PHE A  22
LEU A  62
PHE A  65
 None
 1.10A 5z85P-4cxfA:
undetectable
5z85W-4cxfA:
undetectable		 5z85P-4cxfA:
19.71
5z85W-4cxfA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 PHE A  55
PHE A  22
LEU A  62
PHE A  65
 None
 1.08A 5z86P-4cxfA:
undetectable
5z86W-4cxfA:
undetectable		 5z86P-4cxfA:
19.71
5z86W-4cxfA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
(Cupriavidus
metallidurans) 		4 / 6 PHE A  55
PHE A  22
LEU A  62
PHE A  65
 None
 1.10A 5zcpP-4cxfA:
undetectable
5zcpW-4cxfA:
undetectable		 5zcpP-4cxfA:
19.71
5zcpW-4cxfA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY
(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		4 / 6 SER A  39
ALA A  34
ALA B  18
SER B  19
 None
 0.94A 6bocA-4cxfA:
undetectable
6bocB-4cxfA:
undetectable
6bocC-4cxfA:
undetectable
6bocD-4cxfA:
undetectable		 6bocA-4cxfA:
9.42
6bocB-4cxfA:
9.42
6bocC-4cxfA:
9.42
6bocD-4cxfA:
9.42