SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 5 PHE A  76
GLY A 252
SER A 106
THR A 103
 None
 1.40A 1icvA-4cxhA:
undetectable
1icvB-4cxhA:
undetectable		 1icvA-4cxhA:
18.92
1icvB-4cxhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 7 ILE A 307
ILE A 295
LEU A 259
ILE A 235
 None
 0.89A 2q83A-4cxhA:
undetectable		 2q83A-4cxhA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		5 / 9 VAL A 169
VAL A 170
LYS A 174
THR A 132
GLY A 125
 None
 0.86A 3bjwG-4cxhA:
undetectable		 3bjwG-4cxhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 5 VAL A  11
VAL A  10
GLN A 238
ARG A 309
 None
 1.18A 3bjwB-4cxhA:
undetectable		 3bjwB-4cxhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 7 ASP A 384
GLY A 383
ASP A 366
VAL A 373
 None
 0.74A 3t3cA-4cxhA:
undetectable		 3t3cA-4cxhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		5 / 9 ALA A 117
LYS A 119
ALA A 156
ASP A 155
ARG A 118
 None
 1.36A 3ur0C-4cxhA:
undetectable		 3ur0C-4cxhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		3 / 4 SER A 356
GLY A 408
GLU A 403
 None
 0.56A 4juoA-4cxhA:
undetectable
4juoC-4cxhA:
2.6		 4juoA-4cxhA:
22.08
4juoC-4cxhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		3 / 3 VAL A 266
GLY A 274
LYS A 264
 None
 0.70A 4k50A-4cxhA:
undetectable		 4k50A-4cxhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		3 / 3 VAL A 266
GLY A 274
LYS A 264
 None
 0.73A 4k50E-4cxhA:
undetectable		 4k50E-4cxhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		3 / 3 VAL A 266
GLY A 274
LYS A 264
 None
 0.75A 4k50I-4cxhA:
undetectable		 4k50I-4cxhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		5 / 12 GLY A 422
ASP A 414
GLY A 420
ILE A 330
VAL A 349
 None
A  Y  64 ( 3.8A)
None
None
None
 0.97A 4q5mA-4cxhA:
undetectable		 4q5mA-4cxhA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		3 / 3 ASP A 263
HIS A 315
LYS A 264
 None
 0.99A 4qzuD-4cxhA:
undetectable		 4qzuD-4cxhA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 5 LEU A 113
PHE A 189
ILE A 147
ILE A 187
 None
 1.06A 5dzk4-4cxhA:
undetectable
5dzkg-4cxhA:
2.0
5dzkm-4cxhA:
2.1
5dzkn-4cxhA:
2.3		 5dzk4-4cxhA:
7.41
5dzkg-4cxhA:
18.12
5dzkm-4cxhA:
17.31
5dzkn-4cxhA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		5 / 12 ASP A 311
GLY A 271
GLY A 314
LEU A 233
GLY A 301
 None
 0.96A 5i73A-4cxhA:
undetectable		 5i73A-4cxhA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 4 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.19A 5n0rA-4cxhA:
undetectable		 5n0rA-4cxhA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 4 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.14A 5n0sA-4cxhA:
undetectable		 5n0sA-4cxhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 5 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.21A 5n0tA-4cxhA:
2.0		 5n0tA-4cxhA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 4 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.20A 5n0wA-4cxhA:
undetectable		 5n0wA-4cxhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 5 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.20A 5n0wB-4cxhA:
undetectable		 5n0wB-4cxhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 4 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.19A 5n0xA-4cxhA:
undetectable		 5n0xA-4cxhA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 5 SER A 337
ALA A 338
GLN A 378
THR A 340
 G  Y  53 ( 2.3A)
None
None
U  Y  52 ( 4.3A)
 1.19A 5n4iA-4cxhA:
undetectable		 5n4iA-4cxhA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		4 / 5 ALA A 328
VAL A 388
PHE A 410
ILE A 358
 None
 1.04A 5of1B-4cxhA:
undetectable		 5of1B-4cxhA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4cxh ELONGATION FACTOR 1A
(Oryctolagus
cuniculus) 		3 / 3 HIS A  94
ARG A  68
ILE A  70
 A  c4567 ( 4.3A)
A  c4567 ( 4.5A)
None
 0.60A 6fgdA-4cxhA:
2.6		 6fgdA-4cxhA:
22.20