SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ6_B_CAMB502_0 (CYTOCHROME P450-CAM)	4cxj	KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 (Homo sapiens)	4 / 5	PHE A 107 TYR A 162 VAL A 83 VAL A 79	None	1.35A	1dz6B-4cxjA: undetectable	1dz6B-4cxjA: 13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOT_A_VDNA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4cxj	KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 (Homo sapiens)	5 / 12	TYR A 141 MET A 133 LEU A 81 SER A 166 PHE A 107	None	1.34A	1xotA-4cxjA: undetectable	1xotA-4cxjA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC800_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	4cxj	KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 (Homo sapiens)	3 / 3	ASP A 173 ARG A 169 ALA A 172	None	0.80A	3mbgC-4cxjA: undetectable	3mbgC-4cxjA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_1_BEZ1801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	4cxj	KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 (Homo sapiens)	3 / 3	LEU A 136 PHE A 107 ILE A 137	None	0.75A	5dzk1-4cxjA: undetectable 5dzkF-4cxjA: undetectable 5dzkM-4cxjA: undetectable	5dzk1-4cxjA: 0.73 5dzkF-4cxjA: 19.07 5dzkM-4cxjA: 21.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DZ6_B_CAMB502_0","CYTOCHROME P450-CAM","4cxj","KELCH-LIKE ECH-ASSOCIATED PROTEIN 1","Homo sapiens",4,"PHE A 107;TYR A 162;VAL A  83;VAL A  79","None","1.35A","1dz6B-4cxjA:undetectable","1dz6B-4cxjA:13.45"],["1XOT_A_VDNA101_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","4cxj","KELCH-LIKE ECH-ASSOCIATED PROTEIN 1","Homo sapiens",5,"TYR A 141;MET A 133;LEU A  81;SER A 166;PHE A 107","None","1.34A","1xotA-4cxjA:undetectable","1xotA-4cxjA:17.66"],["3MBG_C_ACTC800_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","4cxj","KELCH-LIKE ECH-ASSOCIATED PROTEIN 1","Homo sapiens",3,"ASP A 173;ARG A 169;ALA A 172","None","0.80A","3mbgC-4cxjA:undetectable","3mbgC-4cxjA:21.71"],["5DZK_1_BEZ1801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","4cxj","KELCH-LIKE ECH-ASSOCIATED PROTEIN 1","Homo sapiens",3,"LEU A 136;PHE A 107;ILE A 137","None","0.75A","5dzk1-4cxjA:undetectable;5dzkF-4cxjA:undetectable;5dzkM-4cxjA:undetectable","5dzk1-4cxjA:0.73;5dzkF-4cxjA:19.07;5dzkM-4cxjA:21.15"]]