SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 4 THR A  54
LEU A  58
VAL A 410
LEU A 414
 DDZ  A  51 ( 4.4A)
None
None
None
 0.88A 1fbmB-4cxkA:
undetectable		 1fbmB-4cxkA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 524
VAL A 457
GLY A 459
ILE A 468
 None
 0.80A 1gtnC-4cxkA:
undetectable
1gtnD-4cxkA:
undetectable		 1gtnC-4cxkA:
8.66
1gtnD-4cxkA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 373
ALA A 376
PHE A 377
GLY A 322
ALA A 323
 None
 1.17A 1nr6A-4cxkA:
undetectable		 1nr6A-4cxkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 437
ASP A 409
ALA A 405
THR A 406
ALA A 450
 None
 1.07A 2gluA-4cxkA:
undetectable		 2gluA-4cxkA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 437
ASP A 409
ALA A 405
THR A 406
ALA A 450
 None
 1.10A 3g88A-4cxkA:
undetectable		 3g88A-4cxkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 437
ASP A 409
ALA A 405
THR A 406
ALA A 450
 None
 1.09A 3g88B-4cxkA:
undetectable		 3g88B-4cxkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 437
ASP A 409
ALA A 405
THR A 406
ALA A 450
 None
 1.09A 3g89B-4cxkA:
undetectable		 3g89B-4cxkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 437
ASP A 409
ALA A 405
THR A 406
ALA A 450
 None
 1.09A 3g8bB-4cxkA:
undetectable		 3g8bB-4cxkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 164
LEU A 135
ASN A 141
TYR A 149
 None
 1.37A 4f8yC-4cxkA:
1.4
4f8yD-4cxkA:
undetectable		 4f8yC-4cxkA:
16.33
4f8yD-4cxkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A  49
ASP A  63
MET A  57
ASP A 523
 None
 1.35A 4iv0A-4cxkA:
1.1		 4iv0A-4cxkA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 436
ASP A 409
ASP A 416
 None
 0.89A 4kicB-4cxkA:
undetectable		 4kicB-4cxkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 210
VAL A 287
MET A 286
ALA A 284
 None
 1.14A 4lb2A-4cxkA:
undetectable		 4lb2A-4cxkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A  49
ASP A  63
MET A  57
ASP A 523
 None
 1.35A 4mwzB-4cxkA:
1.1		 4mwzB-4cxkA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 188
GLY A 185
ALA A 209
MET A 290
 None
 0.89A 4rjdA-4cxkA:
undetectable
4rjdB-4cxkA:
undetectable		 4rjdA-4cxkA:
9.46
4rjdB-4cxkA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.11A 4w5qA-4cxkA:
undetectable		 4w5qA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.05A 4w5rA-4cxkA:
undetectable		 4w5rA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.08A 4w5tA-4cxkA:
undetectable		 4w5tA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 116
ALA A  96
THR A 411
VAL A 407
 None
 0.96A 4xe3B-4cxkA:
undetectable		 4xe3B-4cxkA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.07A 4z4cA-4cxkA:
undetectable		 4z4cA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.10A 4z4fA-4cxkA:
undetectable		 4z4fA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.10A 4z4iA-4cxkA:
undetectable		 4z4iA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  70
ALA A  67
LEU A  90
GLU A  87
VAL A  94
 None
 1.26A 5hw4B-4cxkA:
undetectable		 5hw4B-4cxkA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 476
LEU A 478
ALA A 467
LEU A 492
 None
 0.65A 5jq7A-4cxkA:
undetectable		 5jq7A-4cxkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 9 PHE A 314
VAL A 407
THR A  54
ASN A 318
 None
None
DDZ  A  51 ( 4.4A)
CA  A1528 (-2.7A)
 1.07A 5lg3I-4cxkA:
undetectable		 5lg3I-4cxkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 469
THR A 406
HIS A  46
ALA A 405
 None
 1.44A 5mfxA-4cxkA:
2.1		 5mfxA-4cxkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 202
ASN A   6
ARG A 102
GLY A 105
 None
 1.15A 5o4yA-4cxkA:
undetectable		 5o4yA-4cxkA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 201
VAL A 298
LEU A 189
LEU A 192
 None
 1.04A 6e43D-4cxkA:
undetectable		 6e43D-4cxkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 265
GLU A 264
GLU A 272
 None
 0.91A 6fhwA-4cxkA:
undetectable		 6fhwA-4cxkA:
10.88