SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.40A 1d4fB-4cxoA:
undetectable		 1d4fB-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		4 / 5 HIS A 120
HIS A 130
HIS A   6
ASP A  45
 ZN  A 451 ( 3.4A)
ZN  A 452 (-3.3A)
ZN  A 453 ( 3.2A)
SO4  A 461 ( 2.7A)
 0.97A 1e9yB-4cxoA:
undetectable		 1e9yB-4cxoA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 ASP A 207
ASP A  73
ILE A 214
ASP A 219
THR A  62
 D5M  A 430 ( 4.7A)
None
None
None
None
 1.44A 1kijA-4cxoA:
undetectable		 1kijA-4cxoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		4 / 4 ALA A 216
ARG A 246
GLN A 215
GLU A 212
 None
 1.19A 1lqtB-4cxoA:
undetectable		 1lqtB-4cxoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		4 / 4 ALA A 216
ARG A 246
GLN A 215
GLU A 212
 None
 1.19A 1lquB-4cxoA:
undetectable		 1lquB-4cxoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 10 ASP A  45
HIS A 130
ASP A 124
HIS A   6
HIS A 155
 SO4  A 461 ( 2.7A)
ZN  A 452 (-3.3A)
ZN  A 453 (-2.6A)
ZN  A 453 ( 3.2A)
None
 1.43A 2q0jA-4cxoA:
undetectable		 2q0jA-4cxoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		3 / 3 TYR A 222
GLN A 127
TRP A 220
 None
 1.11A 4kn2C-4cxoA:
undetectable		 4kn2C-4cxoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 ARG A 260
GLN A 245
ILE A 185
VAL A 252
ILE A  12
 None
 1.03A 4uw0A-4cxoA:
undetectable		 4uw0A-4cxoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 GLY A 213
TYR A 209
ILE A 214
ILE A  60
SER A 132
 None
 1.09A 4xudA-4cxoA:
undetectable		 4xudA-4cxoA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.37A 5hm8A-4cxoA:
undetectable		 5hm8A-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.36A 5hm8B-4cxoA:
undetectable		 5hm8B-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.36A 5hm8C-4cxoA:
undetectable		 5hm8C-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.37A 5hm8D-4cxoA:
undetectable		 5hm8D-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.36A 5hm8E-4cxoA:
undetectable		 5hm8E-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.37A 5hm8F-4cxoA:
undetectable		 5hm8F-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.37A 5hm8G-4cxoA:
undetectable		 5hm8G-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.36A 5hm8H-4cxoA:
undetectable		 5hm8H-4cxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		4 / 8 ASP A 124
HIS A 120
HIS A   6
HIS A 130
 ZN  A 453 (-2.6A)
ZN  A 451 ( 3.4A)
ZN  A 453 ( 3.2A)
ZN  A 452 (-3.3A)
 0.92A 5nekD-4cxoA:
undetectable		 5nekD-4cxoA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.36A 6f3mB-4cxoA:
undetectable		 6f3mB-4cxoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_1
(-)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 120
ASP A 124
ASP A 158
HIS A  58
LEU A  42
 ZN  A 451 ( 3.4A)
ZN  A 453 (-2.6A)
ZN  A 452 (-2.0A)
ZN  A 451 ( 3.2A)
None
 1.36A 6f3mD-4cxoA:
undetectable		 6f3mD-4cxoA:
20.65